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European Spine Journal
Published in: European Spine Journal 2/2014

01-02-2014 | Original Article

Clinical characteristics and treatment options for two types of osteoblastoma in the mobile spine: a retrospective study of 32 cases and outcomes

Authors: Huabin Yin, Wang Zhou, Hongyu Yu, Binbin Li, Dan Zhang, Zhipeng Wu, Tielong Liu, Jianru Xiao

Published in: European Spine Journal | Issue 2/2014

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Abstract

Purpose

A retrospective study of 32 patients with osteoblastoma (OBL) in the mobile spine was performed to analyze the clinical characteristics of two types of spinal OBL. We also aimed to find influential factors for OBL in the mobile spine.

Methods

Between 2002 and 2011, 32 patients with either conventional osteoblastoma (CO) or aggressive osteoblastoma (AO) in the mobile spine were treated in our center. All patients were treated with either total excision or subtotal excision + postoperative radiotherapy. The mean follow-up was 45.8 (18–128) months. Clinical data and surgery efficacy were analyzed to search for clinical characteristics of two subtypes of spinal OBL and discuss the possible factors influencing relapse.

Results

There is significant difference between CO and AO in tumor size (p < 0.0005), preoperative alkaline phosphatase (ALP, p < 0.0005) and intraoperative blood loss (p = 0.013). Multivariate logistic regression was used to find the influential factors for relapse and the results were: preoperative ALP, b = 0.023, p = 0.029; surgery protocol, b = −7.597, p = 0.007; tumor size, ≥3/<3, b = 24.805, p < 0.0005; age, b = 0.054, p = 0.632; and pathology type, b = 1.998, p = 0.34.

Conclusions

Tumor size, preoperative ALP and CT images were helpful for distinguishing AO from CO. The difference in intraoperative blood loss between CO and AO is mainly attributed to the size of the lesion. Preoperative ALP, surgery protocol and tumor size (≥3/<3) were considered to significantly influence relapse of spinal OBL.
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Metadata
Title
Clinical characteristics and treatment options for two types of osteoblastoma in the mobile spine: a retrospective study of 32 cases and outcomes
Authors
Huabin Yin
Wang Zhou
Hongyu Yu
Binbin Li
Dan Zhang
Zhipeng Wu
Tielong Liu
Jianru Xiao
Publication date
01-02-2014
Publisher
Springer Berlin Heidelberg
Published in
European Spine Journal / Issue 2/2014
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI
https://doi.org/10.1007/s00586-013-3049-1

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