Skip to main content
Top
Published in: European Spine Journal 1/2014

01-01-2014 | Grand Rounds

Synovial sarcoma of the spine: a case involving paraspinal muscle with extensive calcification and the surgical consideration in treatment

Authors: Junhyung Kim, Sun-Ho Lee, Yoon-La Choi, Go Eun Bae, Eun-Sang Kim, Whan Eoh

Published in: European Spine Journal | Issue 1/2014

Login to get access

Abstract

Introduction

Synovial sarcoma is a rare malignant tumor of the spine. This tumor may present as a painless mass of the spine or slowly enlarge, causing pain or neurologic deficits. As it is difficult to differentiate this lesion from other soft tissue tumors, synovial sarcoma requires histologic confirmation for definite diagnosis. Thus, the treatment strategy is often planned in the final step depending on the pathologic results. Despite its rare incidence, a few cases of primary or metastatic synovial sarcoma involving the spinal cord, foramen, vertebral body, or paraspinal muscles have been reported in the literature.

Materials and methods

We present the case of a 29-year-old man with a synovial sarcoma in the paraspinal muscle of the cervical spine. The patient was evaluated radiologically and histologically. Plain radiography, computed tomography, and magnetic resonance imaging were performed as part of the preoperative workup, and immunohistochemical and cytogenetic studies were additionally performed to identify the histologic features of the tumor. The patient underwent marginal resection followed by adjuvant radiation therapy. The patient has been followed up for 2 years.

Conclusions

This article highlights the features of synovial sarcoma of the spine via a comprehensive review. Synovial sarcoma of the spine is uncommon, but it is a challenging issue in both diagnostic and therapeutic aspects. The currently available evidence suggests the use of a multidisciplinary approach in the treatment of synovial sarcoma, which includes complete resection and radiation therapy.
Literature
1.
go back to reference Canter RJ, Qin LX, Maki RG, Brennan MF, Ladanyi M, Singer S (2008) A synovial sarcoma-specific preoperative nomogram supports a survival benefit to ifosfamide-based chemotherapy and improves risk stratification for patients. Clin Can Res 14:8191–8197CrossRef Canter RJ, Qin LX, Maki RG, Brennan MF, Ladanyi M, Singer S (2008) A synovial sarcoma-specific preoperative nomogram supports a survival benefit to ifosfamide-based chemotherapy and improves risk stratification for patients. Clin Can Res 14:8191–8197CrossRef
2.
go back to reference Eilber FC, Brennan MF, Eilber FR, Eckardt JJ, Grobmyer SR, Riedel E, Forscher C, Maki RG, Singer S (2007) Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma. Ann Surg 246:105–113PubMedCrossRef Eilber FC, Brennan MF, Eilber FR, Eckardt JJ, Grobmyer SR, Riedel E, Forscher C, Maki RG, Singer S (2007) Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma. Ann Surg 246:105–113PubMedCrossRef
3.
4.
go back to reference Guillou L, Benhattar J, Bonichon F, Gallagher G, Terrier P, Stauffer E, Somerhausen Nde S, Michels JJ, Jundt G, Vince DR, Taylor S, Genevay M, Collin F, Trassard M, Coindre JM (2004) Histologic grade, but not SYT–SSX fusion type, is an important prognostic factor in patients with synovial sarcoma: a multicenter, retrospective analysis. J Clin Oncol 22:4040–4050PubMedCrossRef Guillou L, Benhattar J, Bonichon F, Gallagher G, Terrier P, Stauffer E, Somerhausen Nde S, Michels JJ, Jundt G, Vince DR, Taylor S, Genevay M, Collin F, Trassard M, Coindre JM (2004) Histologic grade, but not SYT–SSX fusion type, is an important prognostic factor in patients with synovial sarcoma: a multicenter, retrospective analysis. J Clin Oncol 22:4040–4050PubMedCrossRef
5.
go back to reference Harb WJ, Luna MA, Patel SR, Ballo MT, Roberts DB, Sturgis EM (2007) Survival in patients with synovial sarcoma of the head and neck: association with tumor location, size, and extension. Head Neck 29:731–740PubMedCrossRef Harb WJ, Luna MA, Patel SR, Ballo MT, Roberts DB, Sturgis EM (2007) Survival in patients with synovial sarcoma of the head and neck: association with tumor location, size, and extension. Head Neck 29:731–740PubMedCrossRef
6.
go back to reference O’Sullivan PJ, Harris AC, Munk PL (2008) Radiological features of synovial cell sarcoma. Br J Radiol 81:346–356PubMedCrossRef O’Sullivan PJ, Harris AC, Munk PL (2008) Radiological features of synovial cell sarcoma. Br J Radiol 81:346–356PubMedCrossRef
7.
go back to reference Puffer RC, Daniels DJ, Giannini C, Pichelmann MA, Rose PS, Clarke MJ (2011) Synovial sarcoma of the spine: a report of three cases and review of the literature. Surg Neurol Int 2:18PubMedCentralPubMedCrossRef Puffer RC, Daniels DJ, Giannini C, Pichelmann MA, Rose PS, Clarke MJ (2011) Synovial sarcoma of the spine: a report of three cases and review of the literature. Surg Neurol Int 2:18PubMedCentralPubMedCrossRef
8.
go back to reference Randall RL, Schabel KL, Hitchcock Y, Joyner DE, Albritton KH (2005) Diagnosis and management of synovial sarcoma. Curr Treat Opt Oncol 6:449–459CrossRef Randall RL, Schabel KL, Hitchcock Y, Joyner DE, Albritton KH (2005) Diagnosis and management of synovial sarcoma. Curr Treat Opt Oncol 6:449–459CrossRef
9.
go back to reference Sanchez Reyes JM, Alcaraz Mexia M, Quinones Tapia D, Aramburu JA (1997) Extensively calcified synovial sarcoma. Skel Radiol 26:671–673CrossRef Sanchez Reyes JM, Alcaraz Mexia M, Quinones Tapia D, Aramburu JA (1997) Extensively calcified synovial sarcoma. Skel Radiol 26:671–673CrossRef
10.
go back to reference Spillane AJ, A’Hern R, Judson IR, Fisher C, Thomas JM (2000) Synovial sarcoma: a clinicopathologic, staging, and prognostic assessment. J Clin Oncol 18:3794–3803PubMed Spillane AJ, A’Hern R, Judson IR, Fisher C, Thomas JM (2000) Synovial sarcoma: a clinicopathologic, staging, and prognostic assessment. J Clin Oncol 18:3794–3803PubMed
11.
go back to reference Spurrell EL, Fisher C, Thomas JM, Judson IR (2005) Prognostic factors in advanced synovial sarcoma: an analysis of 104 patients treated at the Royal Marsden Hospital. Ann Oncol 16:437–444PubMedCrossRef Spurrell EL, Fisher C, Thomas JM, Judson IR (2005) Prognostic factors in advanced synovial sarcoma: an analysis of 104 patients treated at the Royal Marsden Hospital. Ann Oncol 16:437–444PubMedCrossRef
12.
go back to reference Sultan I, Rodriguez-Galindo C, Saab R, Yasir S, Casanova M, Ferrari A (2009) Comparing children and adults with synovial sarcoma in the surveillance, epidemiology, and end results program, 1983–2005: an analysis of 1,268 patients. Cancer 115:3537–3547PubMedCrossRef Sultan I, Rodriguez-Galindo C, Saab R, Yasir S, Casanova M, Ferrari A (2009) Comparing children and adults with synovial sarcoma in the surveillance, epidemiology, and end results program, 1983–2005: an analysis of 1,268 patients. Cancer 115:3537–3547PubMedCrossRef
13.
go back to reference Tateishi U, Hasegawa T, Beppu Y, Satake M, Moriyama N (2004) Synovial sarcoma of the soft tissues: prognostic significance of imaging features. J Comput Ass Tomogr 28:140–148CrossRef Tateishi U, Hasegawa T, Beppu Y, Satake M, Moriyama N (2004) Synovial sarcoma of the soft tissues: prognostic significance of imaging features. J Comput Ass Tomogr 28:140–148CrossRef
Metadata
Title
Synovial sarcoma of the spine: a case involving paraspinal muscle with extensive calcification and the surgical consideration in treatment
Authors
Junhyung Kim
Sun-Ho Lee
Yoon-La Choi
Go Eun Bae
Eun-Sang Kim
Whan Eoh
Publication date
01-01-2014
Publisher
Springer Berlin Heidelberg
Published in
European Spine Journal / Issue 1/2014
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI
https://doi.org/10.1007/s00586-013-3034-8

Other articles of this Issue 1/2014

European Spine Journal 1/2014 Go to the issue