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European Spine Journal

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Open Access 01-06-2012 | Review Article

The metabolic basis of adolescent idiopathic scoliosis: 2011 report of the “metabolic” workgroup of the Fondation Yves Cotrel

Authors: Emre Acaroglu, Regis Bobe, Jocelyn Enouf, Ralph Marcucio, Florina Moldovan, Alain Moreau

Published in: European Spine Journal | Issue 6/2012

Abstract

Objective

The purpose of this review is to elucidate the metabolic processes involved in the pathogenesis of adolescent idiopathic scoliosis (AIS) in light of research by the present authors as well as current literature.

Methods

Pathogenetic mechanisms involved in AIS were modeled as (a) a form of neuromuscular scoliosis (in conjunction with an adverse mechanical environment such as bipedality), in which hormonal and other chemical factors act as regulators of skeletal muscle tone and function; (b) as a consequence of an abnormality in growth of the spinal column (in conjunction with an adverse mechanical environment such as bipedality), in which hormones and other chemical factors act as regulators of growth; and (c) as a mechanical failure of one side of the vertebral column due to a defect in trabecular formation or mineralization (in conjunction with an adverse mechanical environment such as bipedality); in which hormonal and other chemical factors act as regulators of bone formation, mineralization and/or resorption.

Results and conclusion

Current evidence supporting these models individually or in combination is discussed.

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Title: The metabolic basis of adolescent idiopathic scoliosis: 2011 report of the “metabolic” workgroup of the Fondation Yves Cotrel
Authors: Emre Acaroglu
Regis Bobe
Jocelyn Enouf
Ralph Marcucio
Florina Moldovan
Alain Moreau
Publication date: 01-06-2012
Publisher: Springer-Verlag
Published in: European Spine Journal / Issue 6/2012
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-012-2245-8

At a glance: The STEP trials

Springer Medicine

The metabolic basis of adolescent idiopathic scoliosis: 2011 report of the “metabolic” workgroup of the Fondation Yves Cotrel

Abstract

Objective

Methods

Results and conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Methods

Results and conclusion

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