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01-12-2009 | Original Article

Modic changes and interleukin 1 gene locus polymorphisms in occupational cohort of middle-aged men

Authors: Jaro Karppinen, Svetlana Solovieva, Katariina Luoma, Raili Raininko, Päivi Leino-Arjas, Hilkka Riihimäki

Published in: European Spine Journal | Issue 12/2009

Abstract

According to recent systematic reviews, Modic changes are associated with low-back pain. However, their pathophysiology remains largely unknown. A previous study of Northern Finnish males implicated that IL1A and MMP3 polymorphisms play a role in type II Modic changes. The purpose of the current study was to examine the association of IL1 cluster polymorphisms with Modic changes amongst middle-aged men in Southern Finland. The final study sample consisted of 108 men from three different occupations, who underwent magnetic resonance imaging (MRI) with a 0.1 T-scanner. Six single nucleotide polymorphisms (SNP) in the IL1 gene cluster (IL1A c.1-889C>T; IL1B c.3954C>T; IL1RN c.1812G>A; IL1RN c.1887G>C; IL1RN c.11100T>C; IL1RN c.1506G>A) were genotyped with the SNP-TRAP method or by allele-specific primer extension on modified microarray. In all, 45 subjects had Modic changes at one or more disc levels. The presence of the minor allele of IL1A (c.1-889C>T) was associated with these changes (any Modic change p = 0.031, type II changes p = 0.036). The carriers of the T-allele had a 2.5-fold risk of Modic change and the association was independent of the other IL1 gene cluster loci studied. In addition, a minor haplotype, with a frequency of 7.5% in the study population, including the minor alleles of IL1A c.1-889C>T, IL1RN c.1812G>A, and IL1RN c.1506G>A, was significantly associated with Modic changes. This observation is in accordance with the previous finding from a different geographical area, and thus confirms the importance of the IL1A gene in the pathophysiology of Modic changes.

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Title: Modic changes and interleukin 1 gene locus polymorphisms in occupational cohort of middle-aged men
Authors: Jaro Karppinen
Svetlana Solovieva
Katariina Luoma
Raili Raininko
Päivi Leino-Arjas
Hilkka Riihimäki
Publication date: 01-12-2009
Publisher: Springer-Verlag
Published in: European Spine Journal / Issue 12/2009
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-009-1139-x

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Springer Medicine

Modic changes and interleukin 1 gene locus polymorphisms in occupational cohort of middle-aged men

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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