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01-10-2008 | Original Article

SAPHO syndrome associated spondylitis

Authors: Tomoyuki Takigawa, Masato Tanaka, Kazuo Nakanishi, Haruo Misawa, Yoshihisa Sugimoto, Tomohiro Takahata, Hiroyuki Nakahara, Shinnosuke Nakahara, Toshifumi Ozaki

Published in: European Spine Journal | Issue 10/2008

Abstract

The concept of synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome has been well clarified, after Chamot et al. suggested this peculiar disorder in 1987. The most commonly affected site in SAPHO syndrome is the anterior chest, followed by the spine. However, the clinical course and taxonomic concept of SAPHO spinal lesions are poorly understood. This study was performed to analyze: (1) the detailed clinical course of spinal lesions in SAPHO syndrome, and (2) the relationship between SAPHO syndrome with spinal lesions and seronegative spondyloarthropathy. Thirteen patients with spondylitis in SAPHO syndrome were analyzed. The features of spinal lesions were a chronic onset with a slight inflammatory reaction, and slowly progressing non-marginal syndesmophytes at multi spinal levels, besides the coexistence of specific skin lesions. SAPHO syndrome, especially spinal lesions related to palmoplantar pustulosis, can be recognized as a subtype of seronegative spondyloarthropathy.

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Title: SAPHO syndrome associated spondylitis
Authors: Tomoyuki Takigawa
Masato Tanaka
Kazuo Nakanishi
Haruo Misawa
Yoshihisa Sugimoto
Tomohiro Takahata
Hiroyuki Nakahara
Shinnosuke Nakahara
Toshifumi Ozaki
Publication date: 01-10-2008
Publisher: Springer-Verlag
Published in: European Spine Journal / Issue 10/2008
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-008-0722-x

At a glance: The STEP trials

Springer Medicine

SAPHO syndrome associated spondylitis

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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