Skip to main content
Top
Published in: European Spine Journal 8/2008

01-08-2008 | Original Article

Are early MRI findings correlated with long-lasting symptoms following whiplash injury? A prospective trial with 1-year follow-up

Authors: Alice Kongsted, Joan S. Sorensen, Hans Andersen, Bjarne Keseler, Troels S. Jensen, Tom Bendix

Published in: European Spine Journal | Issue 8/2008

Login to get access

Abstract

Neck pain is the cardinal symptom following whiplash injuries. The trauma mechanism could theoretically lead to both soft tissue and bone injury that could be visualised by means of MRI. From previous quite small trials it seems that MRI does not demonstrate significant tissue damage. Large prospectively followed cohorts are needed to identify possible clinically relevant MRI findings. The objective of this trial was to evaluate (1) the predictive value of cervical MRI after whiplash injuries and (2) the value of repeating MRI examinations after 3 months including sequences with flexion and extension of the cervical spine. Participants were included after rear-end or frontal car collisions. Patients with fractures or dislocations diagnosed by standard procedures at the emergency unit were not included. MRI scans of the cervical spine were performed at baseline and repeated after 3 months. Clinical follow-ups were performed after 3 and 12 months. Outcome parameters were neck pain, headache, neck disability and working ability. A total of 178 participants had a cervical MRI scan on average 13 days after the injury. Traumatic findings were observed in seven participants. Signs of disc degeneration were common and most frequent at the C5–6 and C6–7 levels. Findings were not associated with outcome after 3 or 12 months. The population had no considerable neck trouble prior to the whiplash injury and the non-traumatic findings represent findings to be expected in the background population. Trauma-related MRI findings are rare in a whiplash population screened for serious injuries in the emergency unit and not related to a specific symptomatology. Also, pre-existing degeneration is not associated with prognosis.
Literature
2.
go back to reference Bolton JE, Wilkinson RC (1998) Responsiveness of pain scales: a comparison of three pain intensity measures in chiropractic patients. J Manipulative Physiol Ther 21:1–7PubMed Bolton JE, Wilkinson RC (1998) Responsiveness of pain scales: a comparison of three pain intensity measures in chiropractic patients. J Manipulative Physiol Ther 21:1–7PubMed
3.
go back to reference Bonuccelli U, Pavese N, Lucetti C, Renna MR et al (1999) Late whiplash syndrome: a clinical and magnetic resonance imaging study. Funct Neurol 14:219–225PubMed Bonuccelli U, Pavese N, Lucetti C, Renna MR et al (1999) Late whiplash syndrome: a clinical and magnetic resonance imaging study. Funct Neurol 14:219–225PubMed
4.
go back to reference Borchgrevink G, Smevik O, Haave I, Haraldseth O et al (1997) MRI of cerebrum and cervical columna within two days after whiplash neck sprain injury. Injury 28:331–335CrossRefPubMed Borchgrevink G, Smevik O, Haave I, Haraldseth O et al (1997) MRI of cerebrum and cervical columna within two days after whiplash neck sprain injury. Injury 28:331–335CrossRefPubMed
5.
go back to reference Borchgrevink GE, Smevik O, Nordby A, Rinck PA et al (1995) MR imaging and radiography of patients with cervical hyperextension—flexion injuries after car accidents. Acta Radiol 36:425–428CrossRefPubMed Borchgrevink GE, Smevik O, Nordby A, Rinck PA et al (1995) MR imaging and radiography of patients with cervical hyperextension—flexion injuries after car accidents. Acta Radiol 36:425–428CrossRefPubMed
6.
go back to reference Cassidy JD, Carroll LJ, Cote P, Lemstra M et al (2000) Effect of eliminating compensation for pain and suffering on the outcome of insurance claims for whiplash injury (see comments). N Engl J Med 342:1179–1186CrossRefPubMed Cassidy JD, Carroll LJ, Cote P, Lemstra M et al (2000) Effect of eliminating compensation for pain and suffering on the outcome of insurance claims for whiplash injury (see comments). N Engl J Med 342:1179–1186CrossRefPubMed
7.
go back to reference Cote P, Cassidy JD, Carroll L, Frank JW et al (2001) A systematic review of the prognosis of acute whiplash and a new conceptual framework to synthesize the literature. Spine 26:E445–E458CrossRefPubMed Cote P, Cassidy JD, Carroll L, Frank JW et al (2001) A systematic review of the prognosis of acute whiplash and a new conceptual framework to synthesize the literature. Spine 26:E445–E458CrossRefPubMed
8.
go back to reference Davis SJ, Teresi LM, Bradley WG Jr., Ziemba MA et al (1991) Cervical spine hyperextension injuries: MR findings. Radiology 180:245–251CrossRefPubMed Davis SJ, Teresi LM, Bradley WG Jr., Ziemba MA et al (1991) Cervical spine hyperextension injuries: MR findings. Radiology 180:245–251CrossRefPubMed
9.
go back to reference Fejer R, Jordan A, Hartvigsen J (2005) Categorising the severity of neck pain: establishment of cut-points for use in clinical and epidemiological research. Pain 119:176–182CrossRefPubMed Fejer R, Jordan A, Hartvigsen J (2005) Categorising the severity of neck pain: establishment of cut-points for use in clinical and epidemiological research. Pain 119:176–182CrossRefPubMed
10.
go back to reference Ferrari R, Obelieniene D, Russell A, Darlington P et al (2002) Laypersons’ expectation of the sequelae of whiplash injury. A cross-cultural comparative study between Canada and Lithuania. Med Sci Monit 8:CR728–CR734PubMed Ferrari R, Obelieniene D, Russell A, Darlington P et al (2002) Laypersons’ expectation of the sequelae of whiplash injury. A cross-cultural comparative study between Canada and Lithuania. Med Sci Monit 8:CR728–CR734PubMed
12.
go back to reference Grauer JN, Panjabi MM, Cholewicki J, Nibu K et al (1997) Whiplash produces an S-shaped curvature of the neck with hyperextension at lower levels. Spine 22:2489–2494CrossRefPubMed Grauer JN, Panjabi MM, Cholewicki J, Nibu K et al (1997) Whiplash produces an S-shaped curvature of the neck with hyperextension at lower levels. Spine 22:2489–2494CrossRefPubMed
13.
go back to reference Hildingsson C, Toolanen G (1990) Outcome after soft-tissue injury of the cervical spine. A prospective study of 93 car-accident victims. Acta Orthop Scand 61:357–359CrossRefPubMed Hildingsson C, Toolanen G (1990) Outcome after soft-tissue injury of the cervical spine. A prospective study of 93 car-accident victims. Acta Orthop Scand 61:357–359CrossRefPubMed
14.
go back to reference Jensen MP, Karoly P, O’Riordan EF, Bland F Jr et al (1989) The subjective experience of acute pain. An assessment of the utility of 10 indices. Clin J Pain 5:153–159CrossRefPubMed Jensen MP, Karoly P, O’Riordan EF, Bland F Jr et al (1989) The subjective experience of acute pain. An assessment of the utility of 10 indices. Clin J Pain 5:153–159CrossRefPubMed
16.
go back to reference Jordan A, Manniche C, Mosdal C, Hindsberger C (1998) The Copenhagen neck functional disability scale: a study of reliability and validity. J Manipulative Physiol Ther 21:520–527PubMed Jordan A, Manniche C, Mosdal C, Hindsberger C (1998) The Copenhagen neck functional disability scale: a study of reliability and validity. J Manipulative Physiol Ther 21:520–527PubMed
17.
go back to reference Karlsborg M, Smed A, Jespersen H, Stephensen S et al (1997) A prospective study of 39 patients with whiplash injury. Acta Neurol Scand 95:65–72CrossRefPubMed Karlsborg M, Smed A, Jespersen H, Stephensen S et al (1997) A prospective study of 39 patients with whiplash injury. Acta Neurol Scand 95:65–72CrossRefPubMed
18.
go back to reference Kasch H, Bach FW, Stengaard-Pedersen K, Jensen TS (2003) Development in pain and neurologic complaints after whiplash: a 1-year prospective study. Neurology 60:743–749CrossRefPubMed Kasch H, Bach FW, Stengaard-Pedersen K, Jensen TS (2003) Development in pain and neurologic complaints after whiplash: a 1-year prospective study. Neurology 60:743–749CrossRefPubMed
19.
20.
go back to reference Kongsted A, Qerama E, Kasch H, Bendix T et al (2007) A randomized early-intervention study on whiplash injuries comparing the effect of a neck collar, “act-as-usual” and active mobilization on one year outcomes. Spine 32:618–626CrossRefPubMed Kongsted A, Qerama E, Kasch H, Bendix T et al (2007) A randomized early-intervention study on whiplash injuries comparing the effect of a neck collar, “act-as-usual” and active mobilization on one year outcomes. Spine 32:618–626CrossRefPubMed
21.
go back to reference Krakenes J, Kaale BR, Moen G, Nordli H et al (2002) MRI assessment of the alar ligaments in the late stage of whiplash injury—a study of structural abnormalities and observer agreement. Neuroradiology 44:617–624CrossRefPubMed Krakenes J, Kaale BR, Moen G, Nordli H et al (2002) MRI assessment of the alar ligaments in the late stage of whiplash injury—a study of structural abnormalities and observer agreement. Neuroradiology 44:617–624CrossRefPubMed
22.
go back to reference Krakenes J, Kaale BR, Moen G, Nordli H et al (2003) MRI of the tectorial and posterior atlanto-occipital membranes in the late stage of whiplash injury. Neuroradiology 46(2):165–166 Krakenes J, Kaale BR, Moen G, Nordli H et al (2003) MRI of the tectorial and posterior atlanto-occipital membranes in the late stage of whiplash injury. Neuroradiology 46(2):165–166
23.
go back to reference Krakenes J, Kaale BR, Nordli H, Moen G et al (2003) MR analysis of the transverse ligament in the late stage of whiplash injury. Acta Radiol 44:637–644CrossRefPubMed Krakenes J, Kaale BR, Nordli H, Moen G et al (2003) MR analysis of the transverse ligament in the late stage of whiplash injury. Acta Radiol 44:637–644CrossRefPubMed
24.
go back to reference Lehto IJ, Tertti MO, Komu ME, Paajanen HE et al (1994) Age-related MRI changes at 0.1 T in cervical discs in asymptomatic subjects. Neuroradiology 36:49–53CrossRefPubMed Lehto IJ, Tertti MO, Komu ME, Paajanen HE et al (1994) Age-related MRI changes at 0.1 T in cervical discs in asymptomatic subjects. Neuroradiology 36:49–53CrossRefPubMed
25.
go back to reference Matsumoto M, Fujimura Y, Suzuki N, Nishi Y et al (1998) MRI of cervical intervertebral discs in asymptomatic subjects. J Bone Joint Surg Br 80:19–24CrossRefPubMed Matsumoto M, Fujimura Y, Suzuki N, Nishi Y et al (1998) MRI of cervical intervertebral discs in asymptomatic subjects. J Bone Joint Surg Br 80:19–24CrossRefPubMed
26.
go back to reference Merl T, Scholz M, Gerhardt P, Langer M et al (1999) Results of a prospective multicenter study for evaluation of the diagnostic quality of an open whole-body low-field MRI unit. A comparison with high-field MRI measured by the applicable gold standard. Eur J Radiol 30:43–53CrossRefPubMed Merl T, Scholz M, Gerhardt P, Langer M et al (1999) Results of a prospective multicenter study for evaluation of the diagnostic quality of an open whole-body low-field MRI unit. A comparison with high-field MRI measured by the applicable gold standard. Eur J Radiol 30:43–53CrossRefPubMed
27.
go back to reference Obelieniene D, Schrader H, Bovim G, Miseviciene I et al (1999) Pain after whiplash: a prospective controlled inception cohort study (see comments). J Neurol Neurosurg Psychiatry 66:279–283CrossRefPubMedPubMedCentral Obelieniene D, Schrader H, Bovim G, Miseviciene I et al (1999) Pain after whiplash: a prospective controlled inception cohort study (see comments). J Neurol Neurosurg Psychiatry 66:279–283CrossRefPubMedPubMedCentral
28.
go back to reference Panjabi MM, Cholewicki J, Nibu K, Grauer J et al (1998) Capsular ligament stretches during in vitro whiplash simulations. J Spinal Disord 11:227–232CrossRefPubMed Panjabi MM, Cholewicki J, Nibu K, Grauer J et al (1998) Capsular ligament stretches during in vitro whiplash simulations. J Spinal Disord 11:227–232CrossRefPubMed
29.
go back to reference Pettersson K, Hildingsson C, Toolanen G, Fagerlund M et al (1994) MRI and neurology in acute whiplash trauma. No correlation in prospective examination of 39 cases. Acta Orthop Scand 65:525–528CrossRefPubMed Pettersson K, Hildingsson C, Toolanen G, Fagerlund M et al (1994) MRI and neurology in acute whiplash trauma. No correlation in prospective examination of 39 cases. Acta Orthop Scand 65:525–528CrossRefPubMed
30.
31.
go back to reference Radanov BP, Sturzenegger M, Di Stefano G (1995) Long-term outcome after whiplash injury. A 2-year follow-up considering features of injury mechanism and somatic, radiologic, and psychosocial findings. Medicine (Baltimore) 74:281–297CrossRef Radanov BP, Sturzenegger M, Di Stefano G (1995) Long-term outcome after whiplash injury. A 2-year follow-up considering features of injury mechanism and somatic, radiologic, and psychosocial findings. Medicine (Baltimore) 74:281–297CrossRef
32.
go back to reference Rand T, Imhof H, Turetschek K, Schneider B et al (1999) Comparison of low field (0.2T) and high field (1.5T) MR imaging in the differentiation of torned from intact menisci. Eur J Radiol 30:22–27CrossRefPubMed Rand T, Imhof H, Turetschek K, Schneider B et al (1999) Comparison of low field (0.2T) and high field (1.5T) MR imaging in the differentiation of torned from intact menisci. Eur J Radiol 30:22–27CrossRefPubMed
33.
go back to reference Ronnen HR, de Korte PJ, Brink PR, van der Bijl HJ et al (1996) Acute whiplash injury: is there a role for MR imaging?—a prospective study of 100 patients. Radiology 201:93–96CrossRefPubMed Ronnen HR, de Korte PJ, Brink PR, van der Bijl HJ et al (1996) Acute whiplash injury: is there a role for MR imaging?—a prospective study of 100 patients. Radiology 201:93–96CrossRefPubMed
34.
go back to reference Sorensen SJ, Kjaer P, Jensen ST, Andersen P (2006) Low-field magnetic resonance imaging of the lumbar spine: reliability of qualitative evaluation of disc and muscle parameters. Acta Radiol 47:947–953CrossRef Sorensen SJ, Kjaer P, Jensen ST, Andersen P (2006) Low-field magnetic resonance imaging of the lumbar spine: reliability of qualitative evaluation of disc and muscle parameters. Acta Radiol 47:947–953CrossRef
35.
go back to reference Spitzer WO, Skovron ML, Salmi LR, Cassidy JD et al. (1995) Scientific monograph of the Quebec Task Force on whiplash-associated disorders: redefining “whiplash” and its management. Spine 20:1S–73S (erratum in Spine 1995, 20(21):2372) Spitzer WO, Skovron ML, Salmi LR, Cassidy JD et al. (1995) Scientific monograph of the Quebec Task Force on whiplash-associated disorders: redefining “whiplash” and its management. Spine 20:1S–73S (erratum in Spine 1995, 20(21):2372)
36.
go back to reference Sterling M, Jull G, Kenardy J (2006) Physical and psychological factors maintain long-term predictive capacity post-whiplash injury. Pain 122:102–108CrossRefPubMed Sterling M, Jull G, Kenardy J (2006) Physical and psychological factors maintain long-term predictive capacity post-whiplash injury. Pain 122:102–108CrossRefPubMed
37.
go back to reference Van Goethem JW, Maes M, Ozsarlak O, van den HL et al (2005) Imaging in spinal trauma. Eur Radiol 15:582–590CrossRefPubMed Van Goethem JW, Maes M, Ozsarlak O, van den HL et al (2005) Imaging in spinal trauma. Eur Radiol 15:582–590CrossRefPubMed
38.
go back to reference Volle E, Montazem A (1997) Strukturdefekte der Ligamenta alaria in der offenen Funktionskernspintomographie. Manuelle Medizin 35:188–193CrossRef Volle E, Montazem A (1997) Strukturdefekte der Ligamenta alaria in der offenen Funktionskernspintomographie. Manuelle Medizin 35:188–193CrossRef
Metadata
Title
Are early MRI findings correlated with long-lasting symptoms following whiplash injury? A prospective trial with 1-year follow-up
Authors
Alice Kongsted
Joan S. Sorensen
Hans Andersen
Bjarne Keseler
Troels S. Jensen
Tom Bendix
Publication date
01-08-2008
Publisher
Springer Berlin Heidelberg
Published in
European Spine Journal / Issue 8/2008
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI
https://doi.org/10.1007/s00586-008-0687-9

Other articles of this Issue 8/2008

European Spine Journal 8/2008 Go to the issue