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01-08-2006 | Review

The vertebral endplate: disc degeneration, disc regeneration

Author: Robert J. Moore

Published in: European Spine Journal | Special Issue 3/2006

Abstract

The vertebral endplates are critical for maintaining disc function yet like other components of the disc are vulnerable to degeneration. This paper provides an overview of the development and normal function of the endplates as well as an impression of what happens when they undergo progressive degeneration. Recent research suggests that the degenerative process can be retarded or reversed.

Aigner T, Gresk-Otter KR, Fairbank JC et al (1998) Variation with age in the pattern of type X collagen expression in normal and scoliotic human intervertebral discs. CalcifTissue Int 63:263–268

Anderson DG, Risbud MV, Shapiro IM, Vaccaro AR, Albert TJ (2005) Cell-based therapy for disc repair. Spine J 5:297S–303SPubMedCrossRef

Antoniou J, Arlet V, Goswami T et al (2001) Elevated synthetic activity in the convex side of scoliotic intervertebral discs and endplates compared with normal tissues. Spine 26:198–206CrossRef

Antoniou J, Goudsouzian M, Heathfield TF et al (1996) The human lumbar endplate. Evidence of changes in biosynthesis and denaturation of the extracellular matrix with growth, maturation, aging, and degeneration. Spine 21:1153–1161PubMedCrossRef

Ariga K, Miyamoto S, Nakase T et al (2001) The relationship between apoptosis of endplate chondrocytes and aging and degeneration of the intervertebral disc. Spine 26:2414–2420PubMedCrossRef

Bayliss MT, Johnstone B (1992) Biochemistry of the intervertebral disc. In: Jayson MIV (ed) The lumbar spine and back pain, 4th edn. Edinburgh, Churchill Livingstone, pp 111–131

Beggs I, Addison J (1998) Posterior vertebral rim fractures. Br J Radiol 71:567–572PubMed

Bernick S, Caillet R (1982) Vertebral end-plate changes with aging of human vertebrae. Spine 7:97–102PubMedCrossRef

Brisby H, Tao H, Ma DDF, Diwan AD (2004) Cell therapy for disc degeneration—potentials and pitfalls. Orthop Clin North Am 35:1–9CrossRef

10.

Broberg KB (1983) On the mechanical behaviour of intervertebral discs. Spine 8:151–165PubMedCrossRef

11.

Brown MF, Hukkanen MVJ, McCarthy ID, Redfern DRM, Batten JJ, Crock HV, Hughes SPF, Polak JM (1997) Sensory and sympathetic innervation of the vertebral endplate in patients with degenerative disc disease. J Bone Joint Surg 79:147–153CrossRef

12.

Chandraraj S, Briggs CA, Opeskin K (1998) Disc herniation in the young and end-plate vascularity. Clin Anat 11:171–176PubMedCrossRef

13.

Crean JK, Roberts S, Jaffray DC et al (1997) Matrix metalloproteinases in the human intervertebral disc: role in disc degeneration and scoliosis. Spine 22:2877–2884PubMedCrossRef

14.

Crock HV, Goldwasser M (1984) Anatomic studies of the circulation in the region of the vertebral endplate in adult greyhound dogs. Spine 9:702–706PubMedCrossRef

15.

Crock HV, Yoshizawa H (1976) The blood supply of the lumbar vertebral column. Clin Orthop Rel Res 115:6–21

16.

Edwards WT, Zheng Y, Ferrara LA, Yuan HA (2001) Structural features and thickness of the vertebral cortex in the thoracolumbar spine. Spine 26:218–225PubMedCrossRef

17.

Fagan AB, Moore RJ, Vernon-Roberts B et al (2003) The innervation of the intervertebral disc: a quantitative analysis. Spine 28:2570–2576PubMedCrossRef

18.

Goupille P, Jayson MI, Valat JP, Freemont AJ (1998) Matrix metalloproteinases: the clue to intervertebral disc degeneration?. Spine 23:612–626CrossRef

19.

Hilton RC, Ball J, Benn RT (1976) Vertebral end-plate lesions (Schmorl’s nodes) in the dorso-lumbar spine. Ann Rheum Dis 35:127–132PubMedCrossRef

20.

Holm S, Maroudas A, Urban JPG et al (1981) Nutrition of the intervertebral disc. Solute transport and metabolism. Connect Tiss Res 8:101–119CrossRef

21.

Hukins DWL (1988) Disc structure and function. In: Ghosh P (ed) The biology of the intervertebral disc. CRC Press, Boca Raton, pp 1–37

22.

Inoue H (1981) Three-dimensional architecture of lumbar intervertebral discs. Spine 6:139–146PubMedCrossRef

23.

Kang JD, Stefanovic-Racic M, McIntyre LA et al (1997) Toward a biochemical understanding of human intervertebral disc degeneration and herniation. Contributions of nitric oxide, interleukins, prostaglandin E2 and matrix metalloproteinases. Spine 22:1065–1073PubMedCrossRef

24.

Levicoff EA, Gilbertson LG, Kang JD (2005) Gene therapy for disc repair. Spine J 5:287S–296SPubMedCrossRef

25.

Lundin O, Ekstrom L, Hellstrom M et al (1998) Injuries in the adolescent porcine spine exposed to mechanical compression. Spine 23:2574–2579PubMedCrossRef

26.

Lundin O, Ekstrom L, Hellstrom M et al (2000) Exposure of the porcine spine to mechanical compression: differences in injury pattern between adolescents and adults. Eur Spine J 9:466–471PubMedCrossRef

27.

McFadden KD, Taylor JR (1989) End-plate lesions of the lumbar spine. Spine 14:867–469PubMedCrossRef

28.

Maroudas A, Stockwell RA, Nachemson A, Urban J (1975) Factors involved in the nutrition of the human lumbar intervertebral disc: cellularity and diffusion of glucose in vitro. J Anat 120:113–130PubMed

29.

Masuda K, An HS (2004) Growth factors and the intervertebral disc. Spine J 4:330S–340SPubMedCrossRef

30.

Moore RJ, Osti OL, Vernon-Roberts B, Fraser RD (1992) Changes in endplate vascularity after an outer anulus tear in the sheep. Spine 17:874–878PubMedCrossRef

31.

Moore RJ, Vernon-Roberts B, Fraser RD et al (1996) The origin and fate of herniated lumbar intervertebral disc tissue. Spine 21:2149–2155PubMedCrossRef

32.

Nachemson A, Lewin T, Maroudas A, Freeman MAR (1970) In vitro diffusion of dye through the endplate and the annulus fibrosus of human intervertebral discs. Acta Orthop Scand 41:589–607PubMedCrossRef

33.

Natarajan RN, Ke JH, Andersson GB (1994) A model to study the disc degeneration process. Spine 19:259–265PubMedCrossRef

34.

Oda J, Tanaka H, Tsuzuki N (1988) Intervertebral disc changes with aging of human cervical vertebra from the neonate to the eighties. Spine 13:1205–1211PubMedCrossRef

35.

Ogata K, Whiteside LA (1981) Nutritional pathways in the intervertebral disc. An experimental study using hydrogen washout technique. Spine 6:211–216PubMedCrossRef

36.

Oki S, Matsuda Y, Shibata T et al (1996) Morphologic differences of the vascular buds in the vertebral endplate—scanning electron microscopic study. Spine 21:174–177PubMedCrossRef

37.

Pearce RH, Grimmer BJ, Adams ME (1987) Degeneration and the chemical composition of the human intervertebral disc. J Orthop Res 5:198–205PubMedCrossRef

38.

Pedrini-Mille A, Pedrini VA, Tudisio C et al (1983) Proteoglycans of human scoliotic intervertebral disc. J Bone Joint Surg 65A:815–823

39.

Pfirrmann CWA, Resnick D (2001) Schmorl nodes of the thoracic and lumbar spine: radiographic–pathologic study of prevalence, characterization, and correlation with degenerative changes of 1,650 spinal levels in 100 cadavers. Radiol 219:368–374

40.

Pooni JS, Hukins DW, Harris PF, Hilton RC, Davies KE (1986) Comparison of the structure of human intervertebral discs in the cervical, thoracic and lumbar regions of the spine. Surg Radiol Anat 8:175–182PubMedCrossRef

41.

Roberts S, Caterson B, Menage J et al (2000) Matrix metalloproteinases and aggrecanase: their role in disorders of the human intervertebral disc. Spine 25:3005–3013PubMedCrossRef

42.

Roberts S, McCall IW, Menage J et al (1997) Does the thickness of the vertebral subchondral bone reflect the composition of the intervertebral disc?. Eur Spine J 6:385–389PubMedCrossRef

43.

Roberts S, Menage J, Eisenstein SM (1993) The cartilage end-plate and intervertebral disc in scoliosis: calcification and other sequelae. J Orthop Res 11:747–757PubMedCrossRef

44.

Roberts S, Menage J, Urban JP (1989) Biochemical and structural properties of the cartilage end-plate and its relation to the intervertebral disc. Spine 14:166–174PubMedCrossRef

45.

Roberts S, Urban JP, Evans H, Eisenstein SM (1996) Transport properties of the human cartilage endplate in relation to its composition and calcification. Spine 21:415–420PubMedCrossRef

46.

Rolander SD, Blair WE (1975) Deformation and fracture of the lumbar vertebral endplates. Orthop Clin North Am 6:75–81PubMed

47.

Sahlman J, Inkinen R, Hirvonen T et al (2001) Premature vertebral endplate ossification and mild disc degeneration in mice after inactivation of one allele belonging to the Col2a1 gene for type II collagen. Spine 26:2558–2565PubMedCrossRef

48.

Schmorl G, Junghanns H (1971) The human spine in health and disease, 2nd edn. Grune and Stratton, New York

49.

Tanaka M, Nakahara S, Inoue H (1993) A pathologic study of discs in the elderly. Separation between the cartilaginous endplate and the vertebral body. Spine 18:1456–1462PubMedCrossRef

50.

Taylor JR, Twomey LT (1988) Growth of human intervertebral discs and vertebral bodies. J Anat 120:49–68

51.

Urban JPG, Holm S, Maroudas A (1978) Diffusion of small solutes into the intervertebral disc. An in vivo study. Biorheology 15:203–221PubMed

52.

Urban JPG, Holm S, Maroudas A, Nachemson A (1977) Nutrition of the intervertebral disc. An in vivo study of solute transport. Clin Orthop Rel Res 129:101–114

53.

Vernon-Roberts B (1992) Age-related and degenerative pathology of intervertebral discs and apophyseal joints. In: Jayson MIV (ed) The lumbar spine and back pain, 4th edn. Edinburgh, Churchill Livingstone, pp 17–41

54.

Vernon-Roberts B, Pirie CJ (1977) Degenerative changes in the intervertebral discs and their sequelae. Rheum Rehab 16:13–21CrossRef

55.

Wallace AL, Wyatt BC, McCarthy ID, Hughes SPF (1994) Humoral regulation of blood flow in the vertebral endplate. Spine 19:1324–1328PubMedCrossRef

56.

Wallach CJ, Gilbertson LG, Kang JD (2003) Gene therapy applications for intervertebral disc degeneration. Spine 28:S93–S98PubMedCrossRef

57.

Weiler C, Nerlich AG, Zipperer J et al (2002) SSE Award Competition in Basic Sciences: expression of major matrix metalloproteinases is associated with intervertebral disc degeneration and resorption. Eur Spine J 11:308–320PubMedCrossRef

58.

Yoon TS (2005) Molecular therapy of the intervertebral disc. Spine J 5:280S–286SPubMedCrossRef

Title: The vertebral endplate: disc degeneration, disc regeneration
Author: Robert J. Moore
Publication date: 01-08-2006
Publisher: Springer-Verlag
Published in: European Spine Journal / Issue Special Issue 3/2006
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-006-0170-4

At a glance: The STEP trials

Springer Medicine

The vertebral endplate: disc degeneration, disc regeneration

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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