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01-10-2004 | Review

Tranexamic acid for major spinal surgery

Author: David T. Neilipovitz

Published in: European Spine Journal | Special Issue 1/2004

Abstract

Patients who undergo major spinal surgery often require multiple blood transfusions. The antifibrinolytics are medications that can reduce blood-transfusion requirements in cardiac surgery and total knee arthroplasty. The present role of synthetic antifibrinolytics, especially tranexamic acid, in reducing peri-operative blood-transfusion requirements in spine surgery is still unclear. The majority of studies exploring the role of these drugs in spine surgery have limited patient enrolment and report mixed results. The goal of the present review is to discuss the pharmacology of tranexamic acid briefly. A brief synopsis of the studies using the synthetic antifibrinolytics for spine surgery is presented. Finally, the potential risks and the benefits of antifibrinolytics are discussed.

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Title: Tranexamic acid for major spinal surgery
Author: David T. Neilipovitz
Publication date: 01-10-2004
Publisher: Springer-Verlag
Published in: European Spine Journal / Issue Special Issue 1/2004
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-004-0716-2

At a glance: The STEP trials

Springer Medicine

Tranexamic acid for major spinal surgery

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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