Top

Published in:

01-09-2018 | Original Article

Blood metabolite profile in Holstein-Friesian cows fed diets varying in dry matter and metabolizable energy density during early lactation

Authors: Frederick Y. Obese, Ahmad Rabiee, Simon Humphrys, Keith Macmillan, Adrian Egan

Published in: Comparative Clinical Pathology | Issue 5/2018

Abstract

Dietary effects on circulating concentrations of some blood metabolites were assessed in Holstein-Friesian cows in early lactation. Thirty-two lactating cows were randomly assigned to receive four diets differing in dry matter intake (DMI) and metabolizable energy (ME) density, namely low dry matter and metabolizable energy (LL), low dry matter and high metabolizable energy (LH), high dry matter and low metabolizable energy (HL), high dry matter and high metabolizable energy (HH), and concentrations of some blood metabolites determined. At the end of the 5-week study, the level of insulin-like growth factor-I (IGF-I) was higher (P < 0.001) in cows on diet HH than those on diets HL, LH, or LL. The glucose concentration was higher (P < 0.001) in cows on HH and LH than those on HL and LL diets, while those of non-esterified fatty acid (NEFA) were similar in cows on the four dietary treatments. Cows fed HL and LL diets recorded higher (P < 0.001) beta-hydroxybutyrate (BHB) concentrations than those on the HH or LH diets. Urea concentration was higher (P < 0.001) in cows on LL than that of their counterparts on the other diets. IGF-I was positively correlated (P < 0.01) with glucose, but negatively related with BHB (P < 0.01) and urea (P < 0.05). Glucose was negatively correlated with BHB (P < 0.01) and urea (P < 0.05). NEFA was negatively correlated with urea (P < 0.05) while BHB was positively correlated with urea (P < 0.01). The levels of metabolites in the blood can reflect the nutritional status of cows during early lactation.

Anderson JB, Friggens NC, Larsen T, Vestergaard M, Ingvartsen KL (2004) Effect of energy density in the diet and milking frequency on plasma metabolites and hormones in early lactation dairy cows. J Veterinary Med Ser A 51:52–57CrossRef

Butler WR (2005) Inhibition of ovulation in the postpartum cow and the lactating sow. Livest Prod Sci 98:5–12CrossRef

Butler ST (2014) Nutritional management to optimize fertility of dairy cows in pasture-based systems. Animal 8(Supplement 1):15–26CrossRefPubMed

Chilliard Y, Bocquier F, Doreau M (1998) Digestive and metabolic adaptations of ruminants to undernutrition, and consequences on reproduction. Reprod Nutr Dev 38:131–152CrossRefPubMed

Cieslak A, El-Sherbiny M, Azczechowiakl J, Kowalczyk D, Pers-kamczyc E, Bryszak M, Szulc P, Jóźwik A, Szumacher-Strabel M (2015) Rapeseed and fish oil mixtures supplied at low dose can modulate milk fatty acid composition without affecting rumen fermentation and productive parameters in dairy cows. Anim Sci Paper Rep 33:357–372

Clark CEF, Fulkerson WJ, Nandra KS, Barchia I, Macmillan KL (2005) The use of indicators to assess the degree of mobilization of body reserves in dairy cows in early lactation on a pasture-based diet. Livest Prod Sci 94:199–211CrossRef

Clarke T, Flinn PC, McGowan AA (1982) Low cost pepsin-cellulase assays for the prediction of digestibility of herbage. Grassland Forage Sci 37:147–150CrossRef

Drackley JK, Cardoso FC (2014) Prepartum and postpartum nutritional management to optimize fertility in high-yielding dairy cows in confined TMR systems. Animal 8(Supplement 1):5–14CrossRefPubMed

Esposito G, Irons PC, Webb EC (2014) Interactions between negative energy balance, metabolic diseases, uterine health and immune response in transition dairy cows. Anim Reprod Sci 144:60–71CrossRefPubMed

Ferguson JD, Galligan DT, Thomas N (1994) Principal descriptors of body condition score in Holstein cows. J Dairy Sci 77:2695–2703CrossRefPubMed

Gábor G, Balogh OG, Kern L, Gábor PR, Fébel H (2016) Nutrition, metabolic status and reproductive efficiency in dairy herds. Open J Anim Sci 6(01):75–84CrossRef

Garro CJ, Mian L, Roldan MC (2014) Subclinical ketosis in dairy cow: prevalence and risk factors in grazing production systems. Anim Physiol Anim Nutr 98:838–844CrossRef

Giuliodori MJ, Delavaud C, Chilliard Y, Becuvillalobos D, Lacau-mengido I, dela Sota RL (2011) High NEFA concentrations around parturition are associated with delayed ovulations in grazing dairy cows. Livest Sci 141:123–128CrossRef

Grala TM, Lucy MC, Phyn CVC, Sheahan AJ, Mee JM, Roche JR (2011) Somatotropic axis and concentrate supplementation in grazing dairy cows of genetically diverse origin. J Dairy Sci 94:303–315CrossRefPubMed

Greenwood PL, Hunt AS, Slepetis RM, Finnerty KD, Alston C, Beermann DH, Bell AW (2002) Effects of birth weight and postnatal nutrition on neonatal sheep III. Regulation of energy metabolism. J Anim Sci 80:2850–2861CrossRefPubMed

Jorritsma R, Wensing T, Kruip TA, Vos PL, Noordhuizen JP (2003) Metabolic changes in early lactation and impaired reproductive performance in dairy cows. Vet Res 34:11–26CrossRefPubMed

Konigsson K, Savoini G, Govoni N, Invernizzi G, Prandi A, Kindahl H, Veronesi MC (2008) Energy balance, leptin, NEFA and IGF-I plasma concentrations and resumption of postpartum ovarian activity in Swedish red and white breed cows. Acta Vet Scand 50:1–7CrossRef

Kuhla B, Metges CC, Hammon HM (2016) Endogenous and dietary lipids influencing feed intake and energy metabolism of periparturient dairy cows. Domest Anim Endocrinol 56:S2–S10CrossRefPubMed

Lake SL, Scholljegerdes EJ, Hallford DM, Moss GE, Rule DC, Hess BW (2006) Effects of body condition score at parturition and postpartum supplemental fat on metabolite and hormone concentrations of beef cows and their suckling calves. J Anim Sci 84:1038–1047CrossRefPubMed

Lee AJ, Twardock AR, Bubar RH, Hall JE, Davis CL (1978) Blood metabolic profiles: their use and relation to nutritional status of dairy cows. J Dairy Sci 61:1652–1670CrossRefPubMed

Mashek DG, Ingvartsen KL, Andersen JB, Vestergaard M, Larsen T (2001) Effects of a four-day hyperinsulinemic-euglycemic clamp in early and mid-lactation dairy cows on plasma concentrations of metabolites, hormones, and binding proteins. Domest Anim Endocrinol 21:169–185CrossRefPubMed

Mcart JA, Nydam DV, Oetzel GR (2012) Epidemiology of subclinical ketosis in early lactation dairy cattle. J Dairy Sci 95:5056–5066CrossRefPubMed

Murphy JJ (1999) The effects of increasing the proportion of molasses in the diet of milking cows on milk production and composition. Anim Feed Sci Technol 79:189–198CrossRef

Ndlovu T, Chimonyo M, Okoh AI, Muchenje V, Dzama K, Raats JG (2007) Assessing the nutritional status of beef cattle: current practices and future prospects. Afr J Biotechnol 6:2727–2734CrossRef

Obese FY (2003) Concentrations of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) in the plasma and milk of pasture-fed dairy cows in early lactation. PhD thesis, School of Agriculture and Food Systems, University of Melbourne, Australia

Obese FY, Humphrys S, Macmillan KL, Egan AR (2008a) Measuring concentrations of insulin-like growth factor-I with an enzyme-linked immunosorbent antibody assay in plasma samples from Holstein cows. J Dairy Sci 91:160–168CrossRefPubMed

Obese FY, Rabiee AR, Macmillan KL, Egan AR, Humphrys S, Anderson GA (2008b) Variation in plasma concentrations of insulin-like growth factor-I in pasture-fed Holstein cows. J Dairy Sci 91:1814–1821CrossRefPubMed

Pedernera M, Garcia S, Horagadoga A, Barchia I, Fulkerson W (2008) Energy balance and reproduction on dairy cows fed to achieve low or high milk production on a pasture-based system. J Dairy Sci 91:3896–3907CrossRefPubMed

SAS (2003) SAS/STAT user guide. SAS. Inst. Inc., Cary

Spicer LJ, Tucker WB, Adams GD (1990) Insulin-like growth factor-I in dairy cows. Relationships among energy balance, body condition, ovarian activity, and estrous behaviour. J Dairy Sci 73:929–937CrossRefPubMed

SPSS (2007) SPSS for windows version 16.0. Chicago, Illinois, U.S. A

Suthar VS, Canelas-Raposo J, Deniz A, Heuwieser W (2013) Prevalence of subclinical ketosis and relationships with postpartum diseases in European dairy cows. J Dairy Sci 96:2925–2938CrossRefPubMed

Thissen JP, Ketelslegers JM, Underwood LE (1994) Nutritional regulation of the insulin-like growth factors. Endocr Rev 15:80–101PubMed

Urdl M, Gruber L, Obritzhauser W, Schauer A (2015) Metabolic parameters and their relationship to energy balance in multiparous Simmental, Brown Swiss and Holstein cows in the periparturient period as influenced by energy supply pre- and post-calving. J Anim Physiol Anim Nutr 99:174–189CrossRef

Walsh SW, Williams EJ, Evans ACO (2011) A review of the causes of poor fertility in high milk producing dairy cows. Anim Reprod Sci 123:127–138CrossRefPubMed

Wathes DC, Chen Z, Bourne N, Taylor VJ, Coffey MP, Brotherstone S (2007) Differences between primiparous and multiparous dairy cows in the inter-relationships between metabolic traits, milk yield and body condition score in the periparturient period. Domest Anim Endocrinol 33:203–225CrossRefPubMed

Whitaker DA, Kelly JM, Smith EJ (1983) Subclinical ketosis and serum beta-hydroxybutyrate levels in dairy cattle. Br Vet J 139:462–463CrossRefPubMed

Zulu VC, Sawamukai Y, Nakada K, Kida K, Moriyoshi M (2002) Relationships among insulin-like growth factor-I, blood metabolites and post-partum ovarian function in dairy cows. J Vet Med Sci 64:879–885CrossRefPubMed

Title: Blood metabolite profile in Holstein-Friesian cows fed diets varying in dry matter and metabolizable energy density during early lactation
Authors: Frederick Y. Obese
Ahmad Rabiee
Simon Humphrys
Keith Macmillan
Adrian Egan
Publication date: 01-09-2018
Publisher: Springer London
Published in: Comparative Clinical Pathology / Issue 5/2018
Print ISSN: 1618-5641
Electronic ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-018-2720-7

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Blood metabolite profile in Holstein-Friesian cows fed diets varying in dry matter and metabolizable energy density during early lactation

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 5/2018

The impact of grape proanthocyanidin extract on dexamethasone-induced osteoporosis and electrolyte imbalance

Hematological, biochemical, serological, and molecular monitoring of blood donor dogs vaccinated with CaniLeish® for the prevention of Leishmaniosis

Spinal cord degeneration in juvenile and adult swine

Effect of high dietary levels of α-tocopherol acetate on immune response of light and heavy weight male broiler breeders

The survey of parasitic infections of wild pigeons (Columba livia) in Lahijan city, Guilan, Iran

Gallotannin promotes cellular death through alteration of redox status