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Published in: Comparative Clinical Pathology 3/2018

01-05-2018 | Original Article

The study on rate of morbidity of fungal infections exiting in educational hospitals: Iran

Authors: Seyyed Amin Ayatollahi Mousavi, Sanaz Hadizadeh, Mahshid Lalvand, Mahboobeh Madani, Azadeh Karami Robati

Published in: Comparative Clinical Pathology | Issue 3/2018

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Abstract

Whereas hospitals have been assumed as the sites for spreading infection at level of world health, therefore, the current descriptive study has been conducted on 248 inpatients and outpatients who were suspected to fungal infection or disease. Samples were collected from several wards along with radiographic and endoscopic analyses in three hospitals, including urine, blood, skin, nail, wound (burning, surgery, eye and injury), lung, phlegm, ascites, bronchoaveolar lavage, (cerebrospinal, abdominal, and knee) fluids, peritoneum, fistula, ear tests and biopsy and sent to reference mycological center. The fungal species were identified by studying their macroscopic and microscopic and using PCR-RFLP technique. Among total studied patients, 180 cases had fungal elements; among which, there were 53 (29%) nosocomial infection and 127 (71%) community-acquired infection cases out of which inpatients and outpatients suffered from fungal diseases. The highest incidence of nosocomial infection belongs to intensive care units (ICU) ward in 16% of patients. The most common isolated fungi were Candida spp. The statistical results of this study suggest nosocomial fungal infections as the most important problems in the course of treatment among hospitalized patients who are more likely to be infected.
Literature
go back to reference Ahmed T, Daad H (2001) Candidemia at a university hospital: epidemiology, risk factors and predictors of mortality. Ann Saudi Med 21(3–4):178–182 Ahmed T, Daad H (2001) Candidemia at a university hospital: epidemiology, risk factors and predictors of mortality. Ann Saudi Med 21(3–4):178–182
go back to reference Fallahi AA, Korbacheh P, Zaini F, Mirhendi H, Zeraati H, Noorbakhsh F et al (2013) Candida species in cutaneous candidiasis patients in the Guilan province in Iran; identified by PCR-RFLP method. Acta Med Iran 51:799–804PubMed Fallahi AA, Korbacheh P, Zaini F, Mirhendi H, Zeraati H, Noorbakhsh F et al (2013) Candida species in cutaneous candidiasis patients in the Guilan province in Iran; identified by PCR-RFLP method. Acta Med Iran 51:799–804PubMed
go back to reference Ferrer C, Colom F, Frasés S, Mulet E, Abad J, Alió J (2001) Detection and identification of fungal pathogens by PCR and by ITS2 and 5.8S ribosomal DNA typing in ocular infections. J Clin Microbiol 39(8):2873–2879CrossRefPubMedPubMedCentral Ferrer C, Colom F, Frasés S, Mulet E, Abad J, Alió J (2001) Detection and identification of fungal pathogens by PCR and by ITS2 and 5.8S ribosomal DNA typing in ocular infections. J Clin Microbiol 39(8):2873–2879CrossRefPubMedPubMedCentral
go back to reference George J (2011) Nosocomial fungal infections: epidemiology, infection control, and prevention. Infect Dis Clin 25(2011):201–225 George J (2011) Nosocomial fungal infections: epidemiology, infection control, and prevention. Infect Dis Clin 25(2011):201–225
go back to reference Gerami shoar M, Zomorodian K, Emami M, Tarazoei B, Saadat F (2002) Study and identification of the etiological agents of onychomycosis in Tehran, capital of Iran. Iran J Publ Health 31(3–4):100–104 Gerami shoar M, Zomorodian K, Emami M, Tarazoei B, Saadat F (2002) Study and identification of the etiological agents of onychomycosis in Tehran, capital of Iran. Iran J Publ Health 31(3–4):100–104
go back to reference Haynes KA, Westerneng TJ (1998) Rapid identification of Candida albicans, C. glabrata, C. parapsilosis and C. krusei by species-specific PCR of large subunit ribosomal DNA. J Med Microbiol 44(5):390–396CrossRef Haynes KA, Westerneng TJ (1998) Rapid identification of Candida albicans, C. glabrata, C. parapsilosis and C. krusei by species-specific PCR of large subunit ribosomal DNA. J Med Microbiol 44(5):390–396CrossRef
go back to reference Kafaie P, Taghi Noorbala M (2010) Evaluation of onychomycosis among diabetic patients of Yazd diabetic center. J Pak Assoc Dermatol 20:217–221 Kafaie P, Taghi Noorbala M (2010) Evaluation of onychomycosis among diabetic patients of Yazd diabetic center. J Pak Assoc Dermatol 20:217–221
go back to reference Karami Robati A, Ayatollahi Mousavi SA, Madani M (2014) Study of nosocomial fungal infections acquired from three Kerman educational hospitals. JRUMS 13(2):151–162 Karami Robati A, Ayatollahi Mousavi SA, Madani M (2014) Study of nosocomial fungal infections acquired from three Kerman educational hospitals. JRUMS 13(2):151–162
go back to reference Kordbacheh P, Zaini F, Kamali P, Ansari K, Safara M (2005) Study on the sources of nosocomial fungal infections at intensive care unit and transplant wards at a teaching hospital in Tehran. Iran J Publ Health 34(2):1–8 Kordbacheh P, Zaini F, Kamali P, Ansari K, Safara M (2005) Study on the sources of nosocomial fungal infections at intensive care unit and transplant wards at a teaching hospital in Tehran. Iran J Publ Health 34(2):1–8
go back to reference Lotfi N, Shokohi T (2014) A review on fungal infection in burn patients, diagnosis and treatment. J Mazand Univ Med Sci 23(108):151–165 Lotfi N, Shokohi T (2014) A review on fungal infection in burn patients, diagnosis and treatment. J Mazand Univ Med Sci 23(108):151–165
go back to reference Mahmoudabadi AZ, Abdoulhosien Masoomi S, Mohammadi H (2010) Clinical and mycological studies of otomycosis. Pak J Med Sci 26(1):187–190 Mahmoudabadi AZ, Abdoulhosien Masoomi S, Mohammadi H (2010) Clinical and mycological studies of otomycosis. Pak J Med Sci 26(1):187–190
go back to reference Nicolle MC, Benet T, Vanhems P (2011) Aspergillosis: nosocomial or community-acquired. Med Mycol 49(1):S24–S29CrossRefPubMed Nicolle MC, Benet T, Vanhems P (2011) Aspergillosis: nosocomial or community-acquired. Med Mycol 49(1):S24–S29CrossRefPubMed
go back to reference Pagano L, Caira M, Candoni A, Offidani M, Fianchi L, Martino B et al (2006) The epidemiology of fungal infections in patients with hematologic malignancies: the SEIFEM-2004 study. Haematol J 91:1068–1075 Pagano L, Caira M, Candoni A, Offidani M, Fianchi L, Martino B et al (2006) The epidemiology of fungal infections in patients with hematologic malignancies: the SEIFEM-2004 study. Haematol J 91:1068–1075
go back to reference Pakshir K, Mogadami M, Emmami M, Kordbacheh P (2004) Prevalence and identification of etiological agents of funguria in Foley catheterized patients. J Med Reser 2(3):33–41 Pakshir K, Mogadami M, Emmami M, Kordbacheh P (2004) Prevalence and identification of etiological agents of funguria in Foley catheterized patients. J Med Reser 2(3):33–41
go back to reference Perlroth J, Choi B, Spellberg B (2007) Nosocomial fungal infections: epidemiology, diagnosis, and treatment. Med Mycol 45(4):321–346CrossRefPubMed Perlroth J, Choi B, Spellberg B (2007) Nosocomial fungal infections: epidemiology, diagnosis, and treatment. Med Mycol 45(4):321–346CrossRefPubMed
go back to reference Proverbio D, Perego R, Spada E, Bagnagatti de Giorgi G, Della Pepa A, Ferro E (2014) Survey of dermatophytes in stray cats with and without skin lesions in northern Italy. Veterin Medic Intern 2014(1):1–4 Proverbio D, Perego R, Spada E, Bagnagatti de Giorgi G, Della Pepa A, Ferro E (2014) Survey of dermatophytes in stray cats with and without skin lesions in northern Italy. Veterin Medic Intern 2014(1):1–4
go back to reference Rangel-Frausto MS, Wiblin T, Blumberg HM (1999) National Epidemiology of Mycoses Survey (NEMIS): Variations in rates of blood stream infections due to Candida species in seven surgical intensive care units and six neonatal intensive care units. Clin Infect Dis 29:253–258.CrossRefPubMed Rangel-Frausto MS, Wiblin T, Blumberg HM (1999) National Epidemiology of Mycoses Survey (NEMIS): Variations in rates of blood stream infections due to Candida species in seven surgical intensive care units and six neonatal intensive care units. Clin Infect Dis 29:253–258.CrossRefPubMed
go back to reference Richards MB, Jonathan R, Edwards MS, David H, Robert P, Gaynes MD (1999) Nosocomial infections in pediatric intensive care units in the United States. National Nosocomial Infections Surveillance System. Pediatr 103(4):e39CrossRef Richards MB, Jonathan R, Edwards MS, David H, Robert P, Gaynes MD (1999) Nosocomial infections in pediatric intensive care units in the United States. National Nosocomial Infections Surveillance System. Pediatr 103(4):e39CrossRef
go back to reference Sherifa M, Moataz M (2012) Epidemiological and microbiological profile of nosocomial infection in Taif hospitals, KSA (2010-2011). World. J Med Sci 7(1):01–09 Sherifa M, Moataz M (2012) Epidemiological and microbiological profile of nosocomial infection in Taif hospitals, KSA (2010-2011). World. J Med Sci 7(1):01–09
go back to reference Takakura S, Fujihara N, Saito T, Kudo T, Iinuma Y, Ichiyama S (2004) National surveillance of species distribution in blood isolates of Candida species in Japan and their susceptibility to six antifungal agents including voriconazole and micafungin. J Antimicrob Chemother 53(2):283–289. https://doi.org/10.1093/jac/dkh053 CrossRefPubMed Takakura S, Fujihara N, Saito T, Kudo T, Iinuma Y, Ichiyama S (2004) National surveillance of species distribution in blood isolates of Candida species in Japan and their susceptibility to six antifungal agents including voriconazole and micafungin. J Antimicrob Chemother 53(2):283–289. https://​doi.​org/​10.​1093/​jac/​dkh053 CrossRefPubMed
go back to reference Tortorano AM, Peman J, Bernhardt H (2004) Epidemiology of candidaemia in Europe: results of 28-month European Confederation of Medical Mycology (ECMM) hospital-based surveillance study. Eur J Clin Microbiol Infect Dis 23(4):317–322CrossRefPubMed Tortorano AM, Peman J, Bernhardt H (2004) Epidemiology of candidaemia in Europe: results of 28-month European Confederation of Medical Mycology (ECMM) hospital-based surveillance study. Eur J Clin Microbiol Infect Dis 23(4):317–322CrossRefPubMed
go back to reference Tzar MN, Shamim AS (2009) Candidaemia and antifungal susceptibility testing in a teaching hospital. Med J Malaysia 64(1):61–64PubMed Tzar MN, Shamim AS (2009) Candidaemia and antifungal susceptibility testing in a teaching hospital. Med J Malaysia 64(1):61–64PubMed
go back to reference Tzar MN, Suhaila B, Shamsul AS, Azizah M (2013) Epidemiology of fungal infections at an infectious disease reference centre in Malaysia. Int Medic Malay 12(1):39 Tzar MN, Suhaila B, Shamsul AS, Azizah M (2013) Epidemiology of fungal infections at an infectious disease reference centre in Malaysia. Int Medic Malay 12(1):39
Metadata
Title
The study on rate of morbidity of fungal infections exiting in educational hospitals: Iran
Authors
Seyyed Amin Ayatollahi Mousavi
Sanaz Hadizadeh
Mahshid Lalvand
Mahboobeh Madani
Azadeh Karami Robati
Publication date
01-05-2018
Publisher
Springer London
Published in
Comparative Clinical Pathology / Issue 3/2018
Print ISSN: 1618-5641
Electronic ISSN: 1618-565X
DOI
https://doi.org/10.1007/s00580-018-2648-y

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