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Comparative Clinical Pathology
Published in: Comparative Clinical Pathology 4/2016

01-07-2016 | Original Article

Ethanol effects on histobiochemical parameters of suckling pups borned from alcoholic rat mothers

Authors: Mojtaba Abbasi, Abdul Rasool Namjoo, Faham Khamesipour

Published in: Comparative Clinical Pathology | Issue 4/2016

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Abstract

Fetus and neonate growth retardation is one of the main characteristics of fetal alcohol syndrome (FAS) disorders. Ethanol can be transferred to the fetus through the placenta and to newborns through suckling. This study was designed to investigate the effects of consuming different doses of ethanol during lactation on enzymatic and tissue changes and growth indices in suckling rat pups. Forty-five lactating Wistar rats with nine lactating pups each were randomly allocated to three treatment groups. The two treatment groups received 2 and 4 % v/v ethanol, while the third group was the control on distilled water for 24 days. On day 25 after birth, 30 newborn rats were randomly selected from each group and serum activity of liver enzyme markers, lactate dehydrogenase, blood urea nitrogen, creatinine, and creatine phosphokinase enzymes was measured. Pathological examinations were performed on brain, liver, and kidney tissues. The obtained data was analyzed using one-way analysis of variance (ANOVA) and Dunnett’s tests. Enzymatic activity of lactate dehydrogenase and creatinine was significantly (p < 0.05) higher in the rats that received alcohol as compared to the control. In histopathological examinations, different injuries were observed in kidney, liver, and brain tissues of suckling pups exposed to 4 % v/v ethanol. Consumption of alcohol in the lactating rats can cause irreparable effects on the suckling neonate.
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Metadata
Title
Ethanol effects on histobiochemical parameters of suckling pups borned from alcoholic rat mothers
Authors
Mojtaba Abbasi
Abdul Rasool Namjoo
Faham Khamesipour
Publication date
01-07-2016
Publisher
Springer London
Published in
Comparative Clinical Pathology / Issue 4/2016
Print ISSN: 1618-5641
Electronic ISSN: 1618-565X
DOI
https://doi.org/10.1007/s00580-016-2270-9

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