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Comparative Clinical Pathology
Published in: Comparative Clinical Pathology 2/2017

01-03-2017 | Review Article

Herbal remedies against gastric cancer in experimental rats

Authors: Aidin Shojaee Tabrizi, Marjan Mohammadi

Published in: Comparative Clinical Pathology | Issue 2/2017

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Abstract

Gastric cancer is the fourth most prevalent cancer worldwide, which claims more than 700,000 lives every year. However, the current chemical and surgical management of this mortal cancer remains far from successful. A recent safe approach to preventing or treating tumorigenesis has been the re-introduction of traditional herbal medicine, taking advantage of efficient, yet natural healthy products. In this review, we have focused on a number of such popular agents, mostly introduced by the Traditional Chinese medicine (TCM), which have exhibited highly significant preventive/therapeutic effects against various gastric pathologies, ranging from gastritis to premalignant lesions and confirmed malignancies, in experimental rats. The underlying mechanisms of action seem to concentrate on shifting the balance between in vivo oxidant and anti-oxidant activities. In addition, the existing reports on the potential toxicity of these compounds, as well as their interactions with chemical drugs, have been presented. However, far more details are required to recommend herbal medicine as an effective and reliable plan of action in gastric cancer management.
Literature
Abdullaev FI (1994) Inhibitory effect of crocetin on intracellular nucleic acid and protein synthesis in malignant cells. Toxicol Lett 70:243–251CrossRefPubMed
Alavizadeh SH, Hosseinzadeh H (2014) Bioactivity assessment and toxicity of crocin: a comprehensive review. Food Chem Toxicol 64:65–80CrossRefPubMed
Bagchi D, Swaroop A, Preuss HG, Bagchi M (2014) Free radical scavenging, antioxidant and cancer chemoprevention by grape seed proanthocyanidin: an overview. Mut Res 768:69–73CrossRef
Bathaie SZ, Hoshyar R, Miri H, Sadeghizadeh M (2013) Anticancer effects of crocetin in both human adenocarcinoma gastric cancer cells and rat model of gastric cancer. Biochem Cell Biol 91:397–403CrossRefPubMed
Chen H-J, Shih C-K, Hsu H-Y, Chiang W (2010) Mast cell-dependent allergic responses are inhibited by ethanolic extract of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) testa. J Agric Food Chem 58:2596–2601CrossRefPubMed
Chen H-H, Chen Y-T, Huang Y-W, Tsai H-J, Kuo C-C (2012) 4-Ketopinoresinol, a novel naturally occurring ARE activator, induces the Nrf2/HO-1 axis and protects against oxidative stress-induced cell injury via activation of PI3K/AKT signaling. Free Radic Biol Med 52:1054–1066CrossRefPubMed
Chung C-P et al (2011) Gastroprotective activities of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on the growth of the stomach cancer AGS cell line and indomethacin-induced gastric ulcers. J Agric Food Chem 59:6025–6033CrossRefPubMed
Dhar A et al (2009) Crocetin inhibits pancreatic cancer cell proliferation and tumor progression in a xenograft mouse model. Mol Cancer Ther 8:315–323CrossRefPubMed
Draudin-Krylenko V, Bukin I, Levchuk A, Davéĭ F (1991) Potential cancer-protective effect of beta-carotene in experimental stomach carcinogenesis. Vopr Med Khim 38:36–39
Dreosti IE, Wargovich MJ, Yang C (1997) Inhibition of carcinogenesis by tea: the evidence from experimental studies. Crit Rev Food Sci Nutr 37:761–770CrossRefPubMed
Ekambaram G, Rajendran P, Magesh V, Sakthisekaran D (2008) Naringenin reduces tumor size and weight lost in N-methyl-N′-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats. Nutr Res 28:106–112CrossRefPubMed
Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127:2893–2917CrossRefPubMed
Giridharan VV, Thandavarayan RA, Mani V, Ashok Dundapa T, Watanabe K, Konishi T (2011) Ocimum sanctum Linn. leaf extracts inhibit acetylcholinesterase and improve cognition in rats with experimentally induced dementia. J Med Food 14:912–919CrossRefPubMed
Hannum SM (2004) Potential impact of strawberries on human health: a review of the science. Crit Rev Food Sci Nutr 44:1–17CrossRefPubMed
Hu P, Wargovich M (1989) Effect of diallyl sulfide on MNNG-induced nuclear aberrations and ornithine decarboxylase activity in the glandular stomach mucosa of the Wistar rat. Cancer Lett 47:153–158CrossRefPubMed
Huang M-T et al (1992) Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin. Carcinogenesis 13:947–954CrossRefPubMed
Huang D-W, Chung C-P, Kuo Y-H, Lin Y-L, Chiang W (2009a) Identification of compounds in adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) seed hull extracts that inhibit lipopolysaccharide-induced inflammation in RAW 264.7 macrophages. J Agric Food Chem 57:10651–10657CrossRefPubMed
Huang D-W, Kuo Y-H, Lin F-Y, Lin Y-L, Chiang W (2009b) Effect of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) Testa and its phenolic components on Cu2+-treated low-density lipoprotein (LDL) oxidation and lipopolysaccharide (LPS)-induced inflammation in RAW 264.7 macrophages. J Agric Food Chem 57:2259–2266CrossRefPubMed
Huang W-Y, H-c Z, W-x L, C-y L (2012) Survey of antioxidant capacity and phenolic composition of blueberry, blackberry, and strawberry in Nanjing. J Zhejiang Univ Sci B 13:94–102CrossRefPubMedPubMedCentral
Huang H-C, Hsieh W-Y, Niu Y-L, Chang T-M (2014) Inhibitory effects of Adlay extract on melanin production and cellular oxygen stress in B16F10 melanoma cells. Int J Mol Sci 15:16665–16679CrossRefPubMedPubMedCentral
Hyun TK, Kim J-S (2009) The pharmacology and clinical properties of Kalopanax pictus. J Med Plants Res 3:613–620
Iwasaki Y, Matsui T, Arakawa Y (2004) The protective and hormonal effects of proanthocyanidin against gastric mucosal injury in Wistar rats. J Gastroenterol 39:831–837CrossRefPubMed
Jiang XY, Qian LP, Zheng XJ, Xia YY, JIANG YB, Sun DY (2009) Interventional effect of Ginkgo biloba extract on the progression of gastric precancerous lesions in rats. J Dig Dis 10:293–299CrossRefPubMed
Jones RC, Sugie S, Braley J, Weisburger JH (1989) Dietary beta-carotene in rat models of gastrointestinal cancer. J Nutr 119:508–514PubMed
Kanwar J, Mujtaba Taskeen IM, Huo C, Chan TH, Dou QP (2012) Recent advances on tea polyphenols. Front Biosci (Elite ed) 4:111–131CrossRef
Katiyar S, Mukhtar H (1996) Tea in chemoprevention of cancer. Int J Oncol 8:221–238PubMed
Kato I, Tominaga S, Matsuura A, Yoshii Y, Shirai M, Kobayashi S (1990) A comparative case control study of colorectal cancer and adenoma. Cancer Sci 81:1101–1108
Ko JK, Leung CC (2010) Ginger extract and polaprezinc exert gastroprotective actions by anti-oxidant and growth factor modulating effects in rats. J Gastroenterol Hepatol 25:1861–1869CrossRefPubMed
Kuo C-C, Chen H-H, Chiang W (2012) Adlay (薏苡 yì yĭ;“soft-shelled job’s tears”; the seeds of Coix lachryma-jobi L. var. ma-yuen Stapf) is a potential cancer chemopreventive agent toward multistage carcinogenesis processes. J Tradit Complement Med 2:267–275CrossRefPubMedPubMedCentral
Li Y, Hu Y, Shi S, Jiang L (2014) Evaluation of antioxidant and immuno-enhancing activities of Purslane polysaccharides in gastric cancer rats. Int J Biol Macromol 68:113–116CrossRefPubMed
Li J, Jiang K, Zhao F (2015) Oxymatrine suppresses proliferation and facilitates apoptosis of human ovarian cancer cells through upregulating microRNA-29b and downregulating matrix metalloproteinase-2 expression. Molecular medicine reports 12:5369–5374PubMed
Liu Y, Xu Y, Ji W, Li X, Sun B, Gao Q, Su C (2014) Anti-tumor activities of matrine and oxymatrine: literature review. Tumor Biol 35:5111–5119CrossRef
Liu N, Sun B, Wu P, Wei X (2015a) Chemopreventive effects of Azadirachta indica on cancer marker indices and ultrastructural changes during 1, 2-dimethylhydrazine-induced colon carcinogenesis in rats. Cell biochemistry and biophysics:1–6
Liu Y, Wang J, Wang W, Zhang H, Zhang X, Han C (2015b) The chemical constituents and pharmacological actions of Cordyceps sinensis. Evidence-Based Complement Altern Med. doi:10.​1155/​2015/​575063
Lopes-da-Silva F, de Pascual-Teresa S, Rivas-Gonzalo J, Santos-Buelga C (2002) Identification of anthocyanin pigments in strawberry (cv Camarosa) by LC using DAD and ESI-MS detection. Eur Food Res Technol 214:248–253CrossRef
Lu B, Xu L, Yu L, Zhang L (2008) Extract of radix curcumae prevents gastric cancer in rats. Digestion 77:87–91CrossRefPubMed
Lu B, Yu L, Xu L, Chen H, Zhang L, Zeng Y (2010) The effects of radix curcumae extract on expressions of VEGF, COX-2 and PCNA in gastric mucosa of rats fed with MNNG. Curr Pharm Biotechnol 11:313–317CrossRefPubMed
Lu J-J, Dang Y-Y, Huang M, Xu W-S, Chen X-P, Wang Y-T (2012) Anti-cancer properties of terpenoids isolated from Rhizoma Curcumae—a review. J Ethnopharmacol 143:406–411CrossRefPubMed
Magesh V, Singh JPV, Selvendiran K, Ekambaram G, Sakthisekaran D (2006) Antitumour activity of crocetin in accordance to tumor incidence, antioxidant status, drug metabolizing enzymes and histopathological studies. Mol Cell Biochem 287:127–135CrossRefPubMed
Manikandan P, Vidjaya LP, Prathiba D, Nagini S (2008) Combinatorial chemopreventive effect of Azadirachta indica and Ocimum sanctum on oxidant-antioxidant status, cell proliferation, apoptosis and angiogenesis in a rat forestomach carcinogenesis model. Singap Med J 49:814–822
Marchbank T, Ojobo E, Playford CJ, Playford RJ (2011) Reparative properties of the traditional Chinese medicine Cordyceps sinensis (Chinese caterpillar mushroom) using HT29 cell culture and rat gastric damage models of injury. Br J Nutr 105:1303–1310CrossRefPubMed
Mei Y, Wei D, Liu J (2005) Modulation effect of tea polyphenol toward N-methyl-N′-nitro-N-nitrosoguanidine-induced precancerous gastric lesion in rats. J Nutr Biochem 16:172–177CrossRefPubMed
Mohammad Alizadeh A et al (2015) Chemoprotection of MNNG-initiated gastric cancer in rats using Iranian propolis. Arch Iranian Med(AIM) 18:18–23
Murugan RS, Mohan KVPC, Uchida K, Hara Y, Prathiba D, Nagini S (2007) Modulatory effects of black tea polyphenols on oxidant–antioxidant profile and expression of proliferation, apoptosis, and angiogenesis-associated proteins in the rat forestomach carcinogenesis model. J Gastroenterol 42:352–361CrossRefPubMed
Narisawa T, Fukaura Y (1993) A very low dose of green tea polyphenols in drinking water prevents N-methyl-N-nitrosourea-induced colon carcinogenesis in F344 rats. Jpn J Cancer Res 84:1007–1009CrossRefPubMed
Paul R, Prasad M, Sah NK (2011) Anticancer biology of Azadirachta indica L (neem): a mini review. Cancer Biol Ther 12:467–476CrossRefPubMed
Poma A, Fontecchio G, Carlucci G, Chichiricco G (2012) Anti-inflammatory properties of drugs from saffron crocus. Antiinflamm Antiallergy Agents Med Chem 11:37–51CrossRefPubMed
Posadzki P, Watson L, Ernst E (2013) Herb–drug interactions: an overview of systematic reviews. Br J Clin Pharmacol 75:603–618PubMedPubMedCentral
Shi X-Y, Zhao F-Z, Dai X, Ma L-S, Dong X-Y, Fang J (2002) Effect of jianpiyiwei capsule on gastric precancerous lesions in rats. World J Gastroenterol 8:608–612CrossRefPubMedPubMedCentral
Sohn YA et al (2015) Protective effect of liriodendrin isolated from Kalopanax pictus against gastric injury. Biomol Ther 23:53–59CrossRef
Tao L, Zhou L, Zheng L, Yao M (2006) Elemene displays anti-cancer ability on laryngeal cancer cells in vitro and in vivo. Cancer Chemother Pharmacol 58:24–34CrossRefPubMed
Tomita H et al (2008) Preventive effect of fermented brown rice and rice bran on N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats. Oncol Rep 19:11–15PubMed
Toreti VC, Sato HH, Pastore GM (2013) Park YK (2013) Recent progress of propolis for its biological and chemical compositions and its botanical origin. Evidence-Based Complement Altern Med. doi:10.​1155/​2013/​697390
Tseng T-H, Chu C-Y, Huang J-M, Shiow S-J, Wang C-J (1995) Crocetin protects against oxidative damage in rat primary hepatocytes. Cancer Lett 97:61–67CrossRefPubMed
Tsuboi K et al (2014) Zerumbone inhibits tumor angiogenesis via NF-κB in gastric cancer. Oncol Rep 31:57–64PubMed
Wang G et al (2005) Antitumor effect of β-elemene in non-small-cell lung cancer cells is mediated via induction of cell cycle arrest and apoptotic cell death. Cell Mol Life Sci CMLS 62:881–893CrossRefPubMed
Wang Z, Hasegawa J, Wang X, Matsuda A, Tokuda T, Miura N, Watanabe T (2011) Protective effects of ginger against aspirin-induced gastric ulcers in rats. Yonago acta medica 54:11–19PubMedPubMedCentral
Wang L, Sun J, Yi Q, Wang X, Ju X (2012) Protective effect of polyphenols extract of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on hypercholesterolemia-induced oxidative stress in rats. Molecules 17:8886–8897CrossRefPubMed
Wang B, Han Q, Zhu Y (2015) Oxymatrine inhibited cell proliferation by inducing apoptosis in human lung cancer A549 cells. Bio-Med Mater Eng 26:165–172CrossRef
Werba PJ et al (2015) Overview of green tea interaction with cardiovascular drugs. Curr Pharm Des 21:1213–1219CrossRefPubMed
Wu C, Huang W, Guo Y, Xia P, Sun X, Pan X, Hu W (2015) Oxymatrine inhibits the proliferation of prostate cancer cells in vitro and in vivo. Mol Med Rep 11:4129–4134PubMedPubMedCentral
Xu Q, Jin X, Ran Z, Yang C, Xiao S (2007) Chemopreventive effect of oxymatrine on N-methyl-N'-nitro-N-nitrosoguanidine induced gastrointestinal cancer: experiment with rats. Zhonghua yi xue za zhi 87:855–858PubMed
Yamane T et al (1995) Inhibition of N-methyl-N′-nitro-N-nitrosoguanidine-induced carcinogenesis by (−)-epigallocatechin gallate in the rat glandular stomach. Cancer Res 55:2081–2084PubMed
Yance DR, Sagar SM (2006) Targeting angiogenesis with integrative cancer therapies. Integr Cancer Ther 5:9–29CrossRefPubMed
Yang W, Li W, Chen J, Chen X (2007) [Preventive effects of 4 Se-enriched plants on rat stomach cancer induced by MNNG--1. Inhibitary effects of different selenium resources on rat aneuploid cell incidence in mucosal epithelium of gastric antrum]. Wei sheng yan jiu. J Hygiene Res 36:612–614
Yang CS, Wang X, Lu G, Picinich SC (2009) Cancer prevention by tea: animal studies, molecular mechanisms and human relevance. Nat Rev Cancer 9:429–439CrossRefPubMedPubMedCentral
Yu F, Gao J, Zeng Y, Liu CX (2011) Effects of adlay seed oil on blood lipids and antioxidant capacity in hyperlipidemic rats. J Sci Food Agric 91:1843–1848CrossRefPubMed
Zaghlool SS, Shehata BA, Abo-Seif AA, El-Latif HAA (2015) Protective effects of ginger and marshmallow extracts on indomethacin-induced peptic ulcer in rats. J Natur Sci biology Med 6:421–428CrossRef
Metadata
Title
Herbal remedies against gastric cancer in experimental rats
Authors
Aidin Shojaee Tabrizi
Marjan Mohammadi
Publication date
01-03-2017
Publisher
Springer London
Published in
Comparative Clinical Pathology / Issue 2/2017
Print ISSN: 1618-5641
Electronic ISSN: 1618-565X
DOI
https://doi.org/10.1007/s00580-016-2239-8

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