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01-01-2016 | Original Article

Combination of diminazene aceturate and resveratrol reduces the toxic effects of chemotherapy in treating Trypanosoma evansi infection

Authors: Matheus D. Baldissera, Nathieli B. Bottari, Virginia C. Rech, Vivian S. K. Nishihira, Camila B. Oliveira, Lara P. Cargnin, Rafael N. Moresco, Gustavo R. Thomé, Maria Rosa C. Schetinger, Vera M. Morsch, Silvia G. Monteiro, Alexandre A. Tonin, Aleksandro S. Da Silva

Published in: Comparative Clinical Pathology | Issue 1/2016

Abstract

The aim of this study was to evaluate the effects of resveratrol (RSV) in its free or complexed (cyclodextrin) forms in association with diminazene aceturate (DA), as an attempt to reduce the toxic effects of this standard chemotherapy on renal and hepatic samples of mice experimentally infected with T. evansi. In this sense, this experiment was designed in order to test the ability of RSV, in its free or complexed forms, on reducing the damage on lipid membrane and protein oxidation, effects usually observed by using DA. Both forms of RSV were used at 100 mg kg⁻¹, during seven consecutive days. As a result, it was observed that, on renal and hepatic samples, RSV in its free form, when combined with DA, was able to inhibit the increase of thiobarbituric acid reactive species levels. DA caused a decrease in the hepatic levels of advanced oxidation protein products, suggesting changes in protein synthesis; however, when it was combined with RSV, this deleterious effect was not observed. It demonstrates that RSV was able to provide some grade of protection against protein oxidation. Therefore, RSV may represent an alternative in reducing the toxic effect caused by chemotherapy in treating of T. evansi infection.

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Title: Combination of diminazene aceturate and resveratrol reduces the toxic effects of chemotherapy in treating Trypanosoma evansi infection
Authors: Matheus D. Baldissera
Nathieli B. Bottari
Virginia C. Rech
Vivian S. K. Nishihira
Camila B. Oliveira
Lara P. Cargnin
Rafael N. Moresco
Gustavo R. Thomé
Maria Rosa C. Schetinger
Vera M. Morsch
Silvia G. Monteiro
Alexandre A. Tonin
Aleksandro S. Da Silva
Publication date: 01-01-2016
Publisher: Springer London
Published in: Comparative Clinical Pathology / Issue 1/2016
Print ISSN: 1618-5641
Electronic ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-015-2154-4

At a glance: The STEP trials

Springer Medicine

Combination of diminazene aceturate and resveratrol reduces the toxic effects of chemotherapy in treating Trypanosoma evansi infection

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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