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01-03-2017 | Review

Immunophenotype, microRNA expression and cytogenetic characterization of acute leukemias of ambiguous lineage

Authors: Neda Golchin, Elahe Khodadi, Seyed Hamid Yaghooti, Kaveh Jaseb, Mohammad Shahjahani, Yousef Tavakolifar, Najmaldin Saki

Published in: Comparative Clinical Pathology | Issue 2/2017

Abstract

Acute leukemias of ambiguous lineage (ALAL) form a group of leukemias presenting the features of both acute lymphoid leukemia (ALL) and acute myeloid leukemia (AML). Based on Immunologic Classification of Leukemia (EGIL), these leukemias are recognized as biphenotype acute leukemia (BAL). According to WHO classification and based on immunophenotypic characteristics, ALAL is further categorized to acute undetermined leukemia (AUL), mixed phenotype acute leukemia (MPAL), and other ambiguous lineage leukemias. Immunophenotype and cytogenetic aspects are important in recognition of these leukemias; however, there is limited data about these leukemias. This has resulted in mistreatment of patients. Thanks to the recent advances and introducing the role of microRNAs in regulation of gene expression, a new avenue has been opened in the field of classification and pathogenesis of ambiguous lineage leukemias. MiRNA-based classification can help define myeloid or lymphoid origin of ambiguous lineage leukemias. Taking immunophenotype, cytogenetic, and miRNA profiles into account collectively, a better recognition of the disease is achieved, which results in accurate diagnosis and effective treatment of patients. In this review, we have discussed ambiguous lineage leukemias with regard to microRNA expression, immunophenotype, and cytogenetic aspects.

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Title: Immunophenotype, microRNA expression and cytogenetic characterization of acute leukemias of ambiguous lineage
Authors: Neda Golchin
Elahe Khodadi
Seyed Hamid Yaghooti
Kaveh Jaseb
Mohammad Shahjahani
Yousef Tavakolifar
Najmaldin Saki
Publication date: 01-03-2017
Publisher: Springer London
Published in: Comparative Clinical Pathology / Issue 2/2017
Print ISSN: 1618-5641
Electronic ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-015-2134-8

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