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01-09-2013 | Original Article

Scolicidal effectiveness of essential oil from Zataria multiflora and Ferula assafoetida: disparity between phenolic monoterpenes and disulphide compounds

Authors: Gholamreza Kavoosi, Amin Mahammadi Purfard

Published in: Comparative Clinical Pathology | Issue 5/2013

Abstract

Hydatidosis in humans and animals is a substantial cause of deaths in many parts of the world. Surgery and the chemotherapeutic agents are the main treatments for hydatid disease; however, most of them are accompanied by adverse side effects. In this study, the scolicidal effect of essential oils from Zataria multiflora and Ferula assafoetida against Echinococcus granulosus protoscolices was investigated. Essential oils from Z. multiflora and F. assafoetida were prepared by hydrodistillation and analyzed by gas chromatography–mass spectrometry. Carvacrol (29.2 %), thymol (25.4 %), p-cymene (11.2 %), linalool (9.6 %), and γ-terpinene (8 %) were detected as the main components of the Z. multiflora, while the main components of F. assafoetida were E-1-propenyl-sec-butyl disulfide (62.7 %), β-ocimene (21.7 %) and β-pinene (5 %). Scolicidal activities of the essential oils against protoscolices for Z. multiflora and F. assafoetida were obtained at concentrations more than 17 and 60 μg/mL, respectively. Accordingly, it was concluded that both essential oils can selectively reduce protoscolices viability, and Z. multiflora, which contains phenolic monoterpenes, is more cytotoxic rather than F. assafoetida which contains disulfide compounds. Therefore, Z. multiflora and F. assafoetida could be recommended as a treatment against hydatid cyst.

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Title: Scolicidal effectiveness of essential oil from Zataria multiflora and Ferula assafoetida: disparity between phenolic monoterpenes and disulphide compounds
Authors: Gholamreza Kavoosi
Amin Mahammadi Purfard
Publication date: 01-09-2013
Publisher: Springer London
Published in: Comparative Clinical Pathology / Issue 5/2013
Print ISSN: 1618-5641
Electronic ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-012-1518-2

At a glance: The STEP trials

Springer Medicine

Scolicidal effectiveness of essential oil from Zataria multiflora and Ferula assafoetida: disparity between phenolic monoterpenes and disulphide compounds

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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