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01-12-2016 | Clinical Report

Prolonged drug-induced myoclonus: is it related to palonosetron?

Authors: Sook Hui Chaw, Lucy Chan, Pui Kuan Lee, Jaseemuddeen A. Bakar, Raveenthiran Rasiah, Li Lian Foo

Published in: Journal of Anesthesia | Issue 6/2016

Abstract

We report a case of drug-induced myoclonus possibly related to palonosetron, a second-generation 5-hydroxytryptamine-3 receptor antagonist which was administered as a prophylaxis for postoperative nausea and vomiting in a 28-year-old female. The recurrent episodes of myoclonus jerk involving the head, neck and shoulder persisted for a period of 4 days. The patient also exhibited an episode of severe bradycardia leading to hypotension 7 h after surgery. To our knowledge, this is the first report presenting these adverse events potentially associated with the use of palonosetron.

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Title: Prolonged drug-induced myoclonus: is it related to palonosetron?
Authors: Sook Hui Chaw
Lucy Chan
Pui Kuan Lee
Jaseemuddeen A. Bakar
Raveenthiran Rasiah
Li Lian Foo
Publication date: 01-12-2016
Publisher: Springer Japan
Published in: Journal of Anesthesia / Issue 6/2016
Print ISSN: 0913-8668
Electronic ISSN: 1438-8359
DOI: https://doi.org/10.1007/s00540-016-2228-8

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Prolonged drug-induced myoclonus: is it related to palonosetron?

Abstract

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Abstract

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