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Journal of Anesthesia
Published in: Journal of Anesthesia 6/2016

01-12-2016 | Invited Review Article

TRPV4 ion channel as important cell sensors

Author: Koji Shibasaki

Published in: Journal of Anesthesia | Issue 6/2016

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Abstract

This review provides a summary of the physiological significance of the TRPV4 ion channel. Although TRPV4 was initially characterized as an osmosensor, we found that TRPV4 can also act as a thermosensor or a mechanosensor in brain neurons or epithelial cells in the urinary bladder. Here, we summarize the newly characterized functions of TRPV4, including the research progress that has been made toward our understanding of TRPV4 physiology, and discuss other recent data pertaining to TRPV4. It is thought that TRPV4 may be an important drug target based on its broad expression patterns and important physiological functions. Possible associations between diseases and TRPV4 are also discussed.
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Metadata
Title
TRPV4 ion channel as important cell sensors
Author
Koji Shibasaki
Publication date
01-12-2016
Publisher
Springer Japan
Published in
Journal of Anesthesia / Issue 6/2016
Print ISSN: 0913-8668
Electronic ISSN: 1438-8359
DOI
https://doi.org/10.1007/s00540-016-2225-y

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