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Journal of Anesthesia
Published in: Journal of Anesthesia 1/2012

01-02-2012 | Clinical Report

Additive diuretic response of concurrent aminophylline and furosemide in children: a case series and a brief literature review

Authors: Paulo Sérgio Lucas da Silva, Vânia Euzébio de Aguiar, Marcelo Cunio Machado Fonseca

Published in: Journal of Anesthesia | Issue 1/2012

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Abstract

Aminophylline exerts a renovascular effect, acting by adenosine receptor blockade or type IV phosphodiesterase inhibition. Clinically, these drugs have been used with furosemide to induce diuresis in adults and neonates. However, reports on use of aminophylline in diuretic-dependent children are limited to a few studies. We report a case series of four critically ill children unresponsive to furosemide continuous infusion who were subsequently given aminophylline as an adjunct diuretic in the treatment of fluid overload. No side effects were evident. Administration of aminophylline at low doses (3 mg/kg) successfully promoted increased urine output over the 6-h study period in all four children.
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Metadata
Title
Additive diuretic response of concurrent aminophylline and furosemide in children: a case series and a brief literature review
Authors
Paulo Sérgio Lucas da Silva
Vânia Euzébio de Aguiar
Marcelo Cunio Machado Fonseca
Publication date
01-02-2012
Publisher
Springer Japan
Published in
Journal of Anesthesia / Issue 1/2012
Print ISSN: 0913-8668
Electronic ISSN: 1438-8359
DOI
https://doi.org/10.1007/s00540-011-1250-0

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