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Published in: Journal of Anesthesia 1/2010

01-02-2010 | Original Article

The effect of landiolol on cerebral blood flow in patients undergoing off-pump coronary artery bypass surgery

Authors: Koji Goto, Satoshi Hagiwara, Seigo Hidaka, Shunsuke Yamamoto, Junya Kusaka, Norihisa Yasuda, Chihiro Shingu, Takayuki Noguchi

Published in: Journal of Anesthesia | Issue 1/2010

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Abstract

Purpose

To examine the effect of landiolol on cerebral blood flow in patients with normal or deteriorated cardiac function.

Methods

Thirty adult patients who were diagnosed with angina pectoris and who underwent elective off-pump coronary artery bypass surgery were studied. Patients were divided into two groups, one with a preoperative left ventricular ejection fraction (EF) of 50% or higher (normal EF group; n = 15) and the other with an EF of less than 50% (low EF group; n = 15). The mean cerebral blood flow velocity (Vmca) and pulsatility index (PI) in the middle cerebral artery were recorded using transcranial Doppler ultrasonography (TCD). Individual hemodynamic data were obtained using a pulmonary arterial catheter.

Results

In both groups, landiolol produced a significant decrease in heart rate (HR), which then returned to baseline 15 min after administration was completed. A significant decrease in mean arterial pressure occurred in the low EF group, but the decrease was within 30% of the baseline. In the normal EF group, there was no decrease in cardiac index (CI), whereas in the low EF group, CI significantly decreased along with the decrease in HR. There were no significant differences in Vmca and PI between the two groups.

Conclusion

Continuous administration of landiolol at a dose of 0.04 mg/kg/min after 1 min rapid IV administration at a dose of 0.125 mg/kg/min decreases HR without causing aggravation of CBF during treatment of intraoperative tachycardia in patients with normal and deteriorated cardiac function.
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Metadata
Title
The effect of landiolol on cerebral blood flow in patients undergoing off-pump coronary artery bypass surgery
Authors
Koji Goto
Satoshi Hagiwara
Seigo Hidaka
Shunsuke Yamamoto
Junya Kusaka
Norihisa Yasuda
Chihiro Shingu
Takayuki Noguchi
Publication date
01-02-2010
Publisher
Springer Japan
Published in
Journal of Anesthesia / Issue 1/2010
Print ISSN: 0913-8668
Electronic ISSN: 1438-8359
DOI
https://doi.org/10.1007/s00540-009-0849-x

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