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Journal of Hepato-Biliary-Pancreatic Sciences

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01-06-2013 | Original article

Gallbladder bed resection or hepatectomy of segments 4a and 5 for pT2 gallbladder carcinoma: analysis of Japanese registration cases by the study group for biliary surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery

Authors: Akihiko Horiguchi, Shuichi Miyakawa, Shin Ishihara, Masaru Miyazaki, Masayuki Ohtsuka, Hiroaki Shimizu, Keiji Sano, Fumihiko Miura, Tetsuo Ohta, Masato Kayahara, Masato Nagino, Tsuyoshi Igami, Satoshi Hirano, Hiroki Yamaue, Masaji Tani, Masakazu Yamamoto, Takehiro Ota, Mitsuo Shimada, Yuji Morine, Hisafumi Kinoshita, Masafumi Yasunaga, Tadahiro Takada

Published in: Journal of Hepato-Biliary-Pancreatic Sciences | Issue 5/2013

Abstract

Purpose

Hepatectomy of segments 4a and 5 (S4a+5) is the recommended treatment for pT2 gallbladder cancer. However, gallbladder bed resection is also occasionally used. Using nationwide data from the Japanese Biliary Tract Cancer Registry and a questionnaire survey, we retrospectively compared these 2 methods of treatment.

Method

The study involved 85 patients with pT2, pN0 gallbladder cancer (55 treated with gallbladder bed resection, and 30, with S4a+5 hepatectomy). The prognosis and mode of tumor recurrence following treatment were analyzed retrospectively, with overall survival as the endpoint.

Results

The 5-year survival rate did not differ significantly between the 2 groups. Univariate analysis showed that bile duct resection and perineural tumor invasion were significant prognostic factors, but the extent of hepatectomy, location of the major intramural tumor, regional lymph node excision, and histological type were not. Multivariate analysis identified perineural tumor invasion as a significant prognostic factor. Recurrence occurred most frequently in both lobes than S4a+5 of the liver following gallbladder bed resection.

Conclusion

In the present study of cases of Japanese Biliary Tract Cancer Registry, it was not possible to conclude that S4a+5 hepatectomy was superior to gallbladder bed resection.

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Title: Gallbladder bed resection or hepatectomy of segments 4a and 5 for pT2 gallbladder carcinoma: analysis of Japanese registration cases by the study group for biliary surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery
Authors: Akihiko Horiguchi
Shuichi Miyakawa
Shin Ishihara
Masaru Miyazaki
Masayuki Ohtsuka
Hiroaki Shimizu
Keiji Sano
Fumihiko Miura
Tetsuo Ohta
Masato Kayahara
Masato Nagino
Tsuyoshi Igami
Satoshi Hirano
Hiroki Yamaue
Masaji Tani
Masakazu Yamamoto
Takehiro Ota
Mitsuo Shimada
Yuji Morine
Hisafumi Kinoshita
Masafumi Yasunaga
Tadahiro Takada
Publication date: 01-06-2013
Publisher: Springer Japan
Published in: Journal of Hepato-Biliary-Pancreatic Sciences / Issue 5/2013
Print ISSN: 1868-6974
Electronic ISSN: 1868-6982
DOI: https://doi.org/10.1007/s00534-012-0584-9

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Springer Medicine

Gallbladder bed resection or hepatectomy of segments 4a and 5 for pT2 gallbladder carcinoma: analysis of Japanese registration cases by the study group for biliary surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery

Abstract

Purpose

Method

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Method

Results

Conclusion

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