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Journal of Hepato-Biliary-Pancreatic Sciences

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01-04-2013 | Original article

Diagnostic and prognostic value of immunohistochemical expression of S100P and IMP3 in transpapillary biliary forceps biopsy samples of extrahepatic bile duct carcinoma

Authors: Hiroki Kawashima, Akihiro Itoh, Eizaburo Ohno, Ryoji Miyahara, Naoki Ohmiya, Tsutomu Tanaka, Yoshie Shimoyama, Shigeo Nakamura, Tomoki Ebata, Masato Nagino, Hidemi Goto, Yoshiki Hirooka

Published in: Journal of Hepato-Biliary-Pancreatic Sciences | Issue 4/2013

Abstract

Background

Because the biopsy specimen of extrahepatic bile duct carcinoma (EHBDC) is small and shows reactive changes, the histological distinction between malignant and benign tissue can be difficult. Recent studies reported that S100P and insulin-like growth factor II mRNA-binding protein 3 (IMP3) were not only diagnostic molecules but also prognostic biomarkers in several organs. The objective of this study is to clarify the diagnostic and prognostic value of immunohistochemical expression of S100P and IMP3 in transpapillary biliary forceps biopsy (TBFB) samples.

Methods

The TBFB samples were collected from 80 patients (EHBDC, 68 patients; benign, 12 patients), retrospectively.

Results

When using cytoplasmic-positive staining for IMP3 as a marker of malignancy, the sensitivity and specificity reached 79.4 and 91.7 %, respectively. The sensitivity, specificity and accuracy achieved 89.7, 91.7 and 90.0 %, respectively, when using positive staining for IMP3 and/or positive histology as a maker of malignancy. While univariate (P = 0.033) and multivariate (P = 0.039) analysis revealed that S100P-positive EHBDC patients showed significantly shorter survival.

Conclusions

The results of this study suggest that immunohistochemical staining for IMP3 is useful in the diagnosis of EHBDC and that of S100P is useful as a prognostic marker for EHBDC.

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Title: Diagnostic and prognostic value of immunohistochemical expression of S100P and IMP3 in transpapillary biliary forceps biopsy samples of extrahepatic bile duct carcinoma
Authors: Hiroki Kawashima
Akihiro Itoh
Eizaburo Ohno
Ryoji Miyahara
Naoki Ohmiya
Tsutomu Tanaka
Yoshie Shimoyama
Shigeo Nakamura
Tomoki Ebata
Masato Nagino
Hidemi Goto
Yoshiki Hirooka
Publication date: 01-04-2013
Publisher: Springer Japan
Published in: Journal of Hepato-Biliary-Pancreatic Sciences / Issue 4/2013
Print ISSN: 1868-6974
Electronic ISSN: 1868-6982
DOI: https://doi.org/10.1007/s00534-012-0581-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Diagnostic and prognostic value of immunohistochemical expression of S100P and IMP3 in transpapillary biliary forceps biopsy samples of extrahepatic bile duct carcinoma

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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