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Journal of Hepato-Biliary-Pancreatic Sciences
Published in: Journal of Hepato-Biliary-Pancreatic Sciences 3/2010

01-05-2010 | Original article

Comparison of the outcomes between anatomical resection and limited resection for single hepatocellular carcinomas no larger than 5 cm in diameter: a single-center study

Authors: Osamu Yamazaki, Mitsuharu Matsuyama, Katsuhiko Horii, Akishige Kanazawa, Sadatoshi Shimizu, Takahiro Uenishi, Masao Ogawa, Yutaka Tamamori, Shuichi Kawai, Kazunori Nakazawa, Hiroshi Otani, Junya Murase, Shinichi Mikami, Ikko Higaki, Yuichi Arimoto, Hiroyuki Hanba

Published in: Journal of Hepato-Biliary-Pancreatic Sciences | Issue 3/2010

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Abstract

Background/Purpose

Liver resection is a widely preferred treatment modality for hepatocellular carcinomas (HCCs). This study aimed to compare the survival impact of anatomical resection with that of limited resection, in patients with single HCCs no larger than 5 cm in diameter.

Methods

A cohort study was carried out on 209 consecutive patients who underwent hepatic resection for a single HCC no larger than 5 cm in diameter between January 1994 and March 2007 at Osaka City General Hospital.

Results

The cumulative 5-year overall survival and disease-free survival rates in the anatomical resection group (n = 111) were 71 and 40%, respectively, both of which were significantly better than the 48 and 25% seen in the limited resection group (n = 98) (P = 0.0043 and P = 0.0232, respectively). Better effects of the anatomical resection on both overall and disease-free survival were seen in patients having HCC larger than 2 cm in diameter and in patients with moderately or poorly differentiated HCC. But no significant difference in either overall or disease-free survival was seen between the groups in patients with a HCC 2 cm or less in diameter or in the patients with well-differentiated HCC. Using Cox’s regression model, anatomical resection was confirmed to be an independent favorable factor for both overall and disease-free survival.

Conclusions

Anatomical resection is therefore recommended for histologically advanced single HCCs ranging from 2 to 5 cm in diameter.
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Metadata
Title
Comparison of the outcomes between anatomical resection and limited resection for single hepatocellular carcinomas no larger than 5 cm in diameter: a single-center study
Authors
Osamu Yamazaki
Mitsuharu Matsuyama
Katsuhiko Horii
Akishige Kanazawa
Sadatoshi Shimizu
Takahiro Uenishi
Masao Ogawa
Yutaka Tamamori
Shuichi Kawai
Kazunori Nakazawa
Hiroshi Otani
Junya Murase
Shinichi Mikami
Ikko Higaki
Yuichi Arimoto
Hiroyuki Hanba
Publication date
01-05-2010
Publisher
Springer Japan
Published in
Journal of Hepato-Biliary-Pancreatic Sciences / Issue 3/2010
Print ISSN: 1868-6974
Electronic ISSN: 1868-6982
DOI
https://doi.org/10.1007/s00534-009-0253-9

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