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Journal of Hepato-Biliary-Pancreatic Sciences
Published in: Journal of Hepato-Biliary-Pancreatic Sciences 3/2010

01-05-2010 | Original article

Risk factors for postoperative recurrence of non-B non-C hepatocellular carcinoma

Authors: Hiroji Shinkawa, Takahiro Uenishi, Shigekazu Takemura, Kazuki Ohba, Masao Ogawa, Tsuyoshi Ichikawa, Shintaro Kodai, Takatsugu Yamamoto, Hiromu Tanaka, Shoji Kubo

Published in: Journal of Hepato-Biliary-Pancreatic Sciences | Issue 3/2010

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Abstract

Background/purpose

The majority of hepatocellular carcinomas are associated with chronic infection with hepatitis B or C virus. Recently, however, the proportion of non-B non-C hepatocellular carcinomas has been increasing. It is necessary to determine the optimal surgical approach for non-B non-C hepatocellular carcinoma.

Methods

Seventy-seven patients with non-B non-C hepatocellular carcinoma who underwent curative hepatic resection were included in this study. Univariate and multivariate analyses were performed to clarify risk factors for postoperative recurrence of non-B non-C hepatocellular carcinoma.

Results

On univariate analysis, surgical margin <5 mm (P = 0.001) and the presence of multiple tumors (P = 0.002) were significantly associated with lower disease-free survival rate. On multivariate analysis, surgical margin <5 mm and the presence of multiple tumors were independent risk factors for postoperative recurrence.

Conclusion

Curative resection with adequate surgical margins for single non-B non-C hepatocellular carcinoma can achieve a good outcome.
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Metadata
Title
Risk factors for postoperative recurrence of non-B non-C hepatocellular carcinoma
Authors
Hiroji Shinkawa
Takahiro Uenishi
Shigekazu Takemura
Kazuki Ohba
Masao Ogawa
Tsuyoshi Ichikawa
Shintaro Kodai
Takatsugu Yamamoto
Hiromu Tanaka
Shoji Kubo
Publication date
01-05-2010
Publisher
Springer Japan
Published in
Journal of Hepato-Biliary-Pancreatic Sciences / Issue 3/2010
Print ISSN: 1868-6974
Electronic ISSN: 1868-6982
DOI
https://doi.org/10.1007/s00534-009-0186-3

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