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Published in: Supportive Care in Cancer 5/2021

Open Access 01-05-2021 | Cytostatic Therapy | Review Article

Energy and caloric restriction, and fasting and cancer: a narrative review

Authors: Ezzeldin M. Ibrahim, Meteb H. Al-Foheidi, Mubarak M. Al-Mansour

Published in: Supportive Care in Cancer | Issue 5/2021

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Abstract

Dietary interventions have a significant impact on body metabolism. The sensitivity of cancer cells to nutrient and energy deficiency is an evolving characteristic of cancer biology. Preclinical studies provided robust evidence that energy and caloric restrictions could hinder both cancer growth and progression, besides enhancing the efficacy of chemotherapy and radiation therapy. Moreover, several, albeit low-powered, clinical trials have demonstrated clinical benefits in cancer patients. Future research will inform and firmly establish the potential efficacy and safety of these dietary interventions. Here, we review the current evidence and ongoing research investigating the relationship between various dietary restriction approaches and cancer outcomes.
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Metadata
Title
Energy and caloric restriction, and fasting and cancer: a narrative review
Authors
Ezzeldin M. Ibrahim
Meteb H. Al-Foheidi
Mubarak M. Al-Mansour
Publication date
01-05-2021
Publisher
Springer Berlin Heidelberg
Published in
Supportive Care in Cancer / Issue 5/2021
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-020-05879-y

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