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Supportive Care in Cancer
Published in: Supportive Care in Cancer 3/2019

01-03-2019 | Review Article

Association between dyadic interventions and outcomes in cancer patients: a meta-analysis

Authors: Yanli Hu, Tao Liu, Fan Li

Published in: Supportive Care in Cancer | Issue 3/2019

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Abstract

Purpose

Patient–caregiver dyadic interventions are when “interventions are offered to cancer patients and their family caregivers together as the unit of care.” The purpose of the present study was to determine the association of dyadic intervention for cancer patients and their family caregivers with quality of life (QOL), and other outcomes for people with cancer.

Methods

Literature searches were conducted using the electronic databases to identify all randomized clinical trials on cancer patient–caregiver dyads. Meta-analysis was used to analyze data.

Results

Twenty-three RCTs provided data on 2317 patient–caregiver dyads. In the meta-analysis, at the 0- to 3-month follow-up, dyadic intervention was associated with statistically and clinically significant improvements in patient total QOL (standardized mean difference [SMD], 0.25; 95% confidence interval [CI], 0.01–0.50); the total spiritual aspect of QOL (SMD, 0.28; 95% CI, 0.06–0.50); the emotional (SMD, 0.16; 95% CI, 0.02–0.29), social (SMD, 0.21; 95% CI, 0.07–0.36), and mental (SMD, 0.26; 95% CI, 0.07–0.46) aspects of QOL; depression (SMD, − 0.35; 95% CI, − 0.65 to − 0.05); anxiety (SMD, − 0.42; 95% CI, − 0.70 to − 0.13); relatedness (SMD, 0.18; 95% CI, 0.04–0.32); and marital functioning (SMD, 1.01; 95% CI, 0.05–1.97). At the 3.1- to 6-month follow-up, dyadic intervention was associated with significant improvements in patient social aspect (SMD, 0.19; 95% CI, 0.03–0.35) and depression (SMD, − 0.29; 95% CI, − 0.56 to − 0.03). There was no association between dyadic interventions and the patient functional and physical aspects of QOL. Dyadic intervention was associated consistently with no improvements in hopelessness, pain, fatigue, and survival.

Conclusions

In this review, dyadic interventions for caregivers and cancer patients were associated with improvements in multiple psychosocial aspects of patient outcomes.
Appendix
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Metadata
Title
Association between dyadic interventions and outcomes in cancer patients: a meta-analysis
Authors
Yanli Hu
Tao Liu
Fan Li
Publication date
01-03-2019
Publisher
Springer Berlin Heidelberg
Published in
Supportive Care in Cancer / Issue 3/2019
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-018-4556-8

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