Aerobic exercise and cardiopulmonary fitness in childhood cancer survivors treated with a cardiotoxic agent: a meta-analysis

go back to reference Howlader N, Noone AM, Krapcho M, Miller D, Bishop K, Kosary CL, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (2017) SEER Cancer statistics review, 1975–2014, National Cancer Institute. Bethesda, MD https://seer.cancer.gov/csr/1975_2014/ Howlader N, Noone AM, Krapcho M, Miller D, Bishop K, Kosary CL, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (2017) SEER Cancer statistics review, 1975–2014, National Cancer Institute. Bethesda, MD https://​seer.​cancer.​gov/​csr/​1975_​2014/​

go back to reference Smith M, Hare ML (2004) An overview of progress in childhood cancer survival. J Pediatr Oncol Nurs 21:160–164CrossRefPubMed Smith M, Hare ML (2004) An overview of progress in childhood cancer survival. J Pediatr Oncol Nurs 21:160–164CrossRefPubMed

go back to reference Armstrong GT, Ross JD (2014) Late cardiotoxicity in aging adult survivors of childhood cancer. Prog Pediatr Cardiol 36:19–26CrossRefPubMedPubMedCentral Armstrong GT, Ross JD (2014) Late cardiotoxicity in aging adult survivors of childhood cancer. Prog Pediatr Cardiol 36:19–26CrossRefPubMedPubMedCentral

go back to reference Mertens AC, Liu Q, Neglia LP, Wasilewski K, Leisenring W, Armstrong GT, Robison LL, Yasui Y (2008) Cause-specific late mortality among 5-year survivors of childhood cancer: the Childhood Cancer Survivor Study. 100:1368–1379 Mertens AC, Liu Q, Neglia LP, Wasilewski K, Leisenring W, Armstrong GT, Robison LL, Yasui Y (2008) Cause-specific late mortality among 5-year survivors of childhood cancer: the Childhood Cancer Survivor Study. 100:1368–1379

go back to reference Schlitt A, Jordan K, Vordermark D, Schwamborn J, Langer T, Thomssen C (2014) Cardiotoxicity and oncological treatments. Dtsch Arztebl Int 111:161–168PubMedPubMedCentral Schlitt A, Jordan K, Vordermark D, Schwamborn J, Langer T, Thomssen C (2014) Cardiotoxicity and oncological treatments. Dtsch Arztebl Int 111:161–168PubMedPubMedCentral

go back to reference Adao R, de Keulenaer G, Leite-Moreira A, Bras-Silva C (2013) Cardiotoxicity associated with cancer therapy: pathophysiology and prevention strategies. Rev Port Cardiol 32:395–409PubMedCrossRef Adao R, de Keulenaer G, Leite-Moreira A, Bras-Silva C (2013) Cardiotoxicity associated with cancer therapy: pathophysiology and prevention strategies. Rev Port Cardiol 32:395–409PubMedCrossRef

go back to reference Aleman BM, van den Belt-Dusebout AW, De Bruin ML, van’t Veer MB, Baaijens MH, de Boer JP, Hart AA, Klokman WJ, Kuenen MA, Ouwens GM, Bartelink H, van Leeuwen FE (2007) Late cardiotoxicity after treatment for Hodgkin lymphoma. Blood 109:1878–1886CrossRefPubMed Aleman BM, van den Belt-Dusebout AW, De Bruin ML, van’t Veer MB, Baaijens MH, de Boer JP, Hart AA, Klokman WJ, Kuenen MA, Ouwens GM, Bartelink H, van Leeuwen FE (2007) Late cardiotoxicity after treatment for Hodgkin lymphoma. Blood 109:1878–1886CrossRefPubMed

go back to reference Bovelli D, Plataniotis G, Roila F, ESMO Guidelines Working Group (2010) Cardiotoxicity of chemotherapeutic agents and radiotherapy-related heart disease: ESMO Clinical Practice Guidelines. Ann Oncol 21(Suppl 5):v277–v282CrossRefPubMed Bovelli D, Plataniotis G, Roila F, ESMO Guidelines Working Group (2010) Cardiotoxicity of chemotherapeutic agents and radiotherapy-related heart disease: ESMO Clinical Practice Guidelines. Ann Oncol 21(Suppl 5):v277–v282CrossRefPubMed

go back to reference Jones RL, Swanton C, Ewer MS (2006) Anthracycline cardiotoxicity. Expert Opin Drug Saf 5:791–809CrossRefPubMed Jones RL, Swanton C, Ewer MS (2006) Anthracycline cardiotoxicity. Expert Opin Drug Saf 5:791–809CrossRefPubMed

go back to reference Chen MH, Colan SD, Diller L (2011) Cardiovascular disease: cause of morbidity and mortality in adult survivors of childhood cancers. Circ Res 108:619–628CrossRefPubMed Chen MH, Colan SD, Diller L (2011) Cardiovascular disease: cause of morbidity and mortality in adult survivors of childhood cancers. Circ Res 108:619–628CrossRefPubMed

go back to reference Harake D, Franco VI, Henkel JM, Miller TL, Lipshultz SE (2012) Cardiotoxicity in childhood cancer survivors: strategies for prevention and management. Futur Cardiol 8:647–670CrossRef Harake D, Franco VI, Henkel JM, Miller TL, Lipshultz SE (2012) Cardiotoxicity in childhood cancer survivors: strategies for prevention and management. Futur Cardiol 8:647–670CrossRef

go back to reference van Laar M, Feltbower RG, Gale CP, Bowen DT, Oliver SE, Glaser A (2014) Cardiovascular sequelae in long-term survivors of young peoples’ cancer: a linked cohort study. Br J Cancer 110:1338–1341CrossRefPubMedPubMedCentral van Laar M, Feltbower RG, Gale CP, Bowen DT, Oliver SE, Glaser A (2014) Cardiovascular sequelae in long-term survivors of young peoples’ cancer: a linked cohort study. Br J Cancer 110:1338–1341CrossRefPubMedPubMedCentral

go back to reference Franco VI, Lipshultz SE (2015) Cardiac complications in childhood cancer survivors treated with anthracyclines. Cardiol Young 25(Suppl 2):107–116CrossRefPubMed Franco VI, Lipshultz SE (2015) Cardiac complications in childhood cancer survivors treated with anthracyclines. Cardiol Young 25(Suppl 2):107–116CrossRefPubMed

go back to reference van Dalen EC, van der Pal HJ, Caron HN, Kremer LC (2009) Different dosage schedules for reducing cardiotoxicity in cancer patients receiving anthracycline chemotherapy. Cochrane Database Syst Rev (4):CD005008. https://doi.org/10.1002/14651858.CD005008.pub3. van Dalen EC, van der Pal HJ, Caron HN, Kremer LC (2009) Different dosage schedules for reducing cardiotoxicity in cancer patients receiving anthracycline chemotherapy. Cochrane Database Syst Rev (4):CD005008. https://​doi.​org/​10.​1002/​14651858.​CD005008.​pub3.

go back to reference Hutchins KK, Siddeek H, Franco VI, Lipshultz SE (2017) Prevention of cardiotoxicity among survivors of childhood cancer. Br J Clin Pharmacol 83:455–465CrossRefPubMed Hutchins KK, Siddeek H, Franco VI, Lipshultz SE (2017) Prevention of cardiotoxicity among survivors of childhood cancer. Br J Clin Pharmacol 83:455–465CrossRefPubMed

go back to reference Hodgson DC (2011) Late effects in the era of modern therapy for Hodgkin lymphoma. Hematol Am Soc Hematol Educ Program 2011:323–329 Hodgson DC (2011) Late effects in the era of modern therapy for Hodgkin lymphoma. Hematol Am Soc Hematol Educ Program 2011:323–329

go back to reference Wouters KA, Kremer LC, Miller TL, Herman EH, Lipshultz SE (2005) Protecting against anthracycline-induced myocardial damage: a review of the most promising strategies. Br J Haematol 131:561–578CrossRefPubMed Wouters KA, Kremer LC, Miller TL, Herman EH, Lipshultz SE (2005) Protecting against anthracycline-induced myocardial damage: a review of the most promising strategies. Br J Haematol 131:561–578CrossRefPubMed

go back to reference Brenner DJ, Shuryak I, Jozsef G, Dewyngaert KJ, Formenti SC (2014) Risk and risk reduction of major coronary events associated with contemporary breast radiotherapy. JAMA Intern Med 174:158–160CrossRefPubMed Brenner DJ, Shuryak I, Jozsef G, Dewyngaert KJ, Formenti SC (2014) Risk and risk reduction of major coronary events associated with contemporary breast radiotherapy. JAMA Intern Med 174:158–160CrossRefPubMed

go back to reference Sieswerda E, van Dalen EC, Postma A, Cheuk DK, Caron HN, Kremer LC (2011) Medical interventions for treating anthracycline-induced symptomatic and asymptomatic cardiotoxicity during and after treatment for childhood cancer. Cochrane Database Syst Rev (9):CD008011. https://doi.org/10.1002/14651858.CD008011.pub2. Sieswerda E, van Dalen EC, Postma A, Cheuk DK, Caron HN, Kremer LC (2011) Medical interventions for treating anthracycline-induced symptomatic and asymptomatic cardiotoxicity during and after treatment for childhood cancer. Cochrane Database Syst Rev (9):CD008011. https://​doi.​org/​10.​1002/​14651858.​CD008011.​pub2.

go back to reference Hamer M, Ingle L, Carroll S, Stamatakis E (2012) Physical activity and cardiovascular mortality risk: possible protective mechanisms? Med Sci Sports Exerc 44:84–88CrossRefPubMed Hamer M, Ingle L, Carroll S, Stamatakis E (2012) Physical activity and cardiovascular mortality risk: possible protective mechanisms? Med Sci Sports Exerc 44:84–88CrossRefPubMed

go back to reference Hopper I, Billah B, Skiba M, Krum H (2011) Prevention of diabetes and reduction in major cardiovascular events in studies of subjects with prediabetes: meta-analysis of randomised controlled clinical trials. Eur J Cardiovasc Prev Rehabil 18:813–823CrossRefPubMed Hopper I, Billah B, Skiba M, Krum H (2011) Prevention of diabetes and reduction in major cardiovascular events in studies of subjects with prediabetes: meta-analysis of randomised controlled clinical trials. Eur J Cardiovasc Prev Rehabil 18:813–823CrossRefPubMed

go back to reference Saunders DH, Sanderson M, Hayes S, Kilrane M, Greig CA, Brazzelli M, Mead GE (2016) Physical fitness training for stroke patients. Cochrane Database Syst Rev 3:CD003316. https://doi.org/10.1002/14651858.CD003316.pub6 PubMedCrossRef Saunders DH, Sanderson M, Hayes S, Kilrane M, Greig CA, Brazzelli M, Mead GE (2016) Physical fitness training for stroke patients. Cochrane Database Syst Rev 3:CD003316. https://​doi.​org/​10.​1002/​14651858.​CD003316.​pub6 PubMedCrossRef

go back to reference Fletcher GF, Balady G, Blair SN, Blumenthal J, Caspersen C, Chaitman B, Epstein S, Sivarajan Froelicher ES, Froelicher VF, Pina IL, Pollock ML (1996) Statement on exercise: benefits and recommendations for physical activity programs for all Americans. A statement for health professionals by the Committee on Exercise and Cardiac Rehabilitation of the Council on Clinical Cardiology, American Heart Association. Circulation 94:857–862CrossRefPubMed Fletcher GF, Balady G, Blair SN, Blumenthal J, Caspersen C, Chaitman B, Epstein S, Sivarajan Froelicher ES, Froelicher VF, Pina IL, Pollock ML (1996) Statement on exercise: benefits and recommendations for physical activity programs for all Americans. A statement for health professionals by the Committee on Exercise and Cardiac Rehabilitation of the Council on Clinical Cardiology, American Heart Association. Circulation 94:857–862CrossRefPubMed

go back to reference Naci H, Ioannidis JP (2013) Comparative effectiveness of exercise and drug interventions on mortality outcomes: meta-epidemiological study. BMJ 347:f5577. https://doi.org/10.1136/bmj.f5577 CrossRefPubMedPubMedCentral Naci H, Ioannidis JP (2013) Comparative effectiveness of exercise and drug interventions on mortality outcomes: meta-epidemiological study. BMJ 347:f5577. https://​doi.​org/​10.​1136/​bmj.​f5577 CrossRefPubMedPubMedCentral

go back to reference Riner WF, Sellhorst SH (2013) Physical activity and exercise in children with chronic health conditions. 2:12–20 Riner WF, Sellhorst SH (2013) Physical activity and exercise in children with chronic health conditions. 2:12–20

go back to reference Kelly AK (2011) Physical activity prescription for childhood cancer survivors. Curr Sports Med Rep 10:352–359CrossRefPubMed Kelly AK (2011) Physical activity prescription for childhood cancer survivors. Curr Sports Med Rep 10:352–359CrossRefPubMed

go back to reference Baumann FT, Bloch W, Beulertz J (2013) Clinical exercise interventions in pediatric oncology: a systematic review. Pediatr Res 74:366–374CrossRefPubMed Baumann FT, Bloch W, Beulertz J (2013) Clinical exercise interventions in pediatric oncology: a systematic review. Pediatr Res 74:366–374CrossRefPubMed

go back to reference Miller TL, Horgan S, Lipshultz SE (2005) Exercise rehabilitation of pediatric patients with cardiovascular disease. 20:27–37 Miller TL, Horgan S, Lipshultz SE (2005) Exercise rehabilitation of pediatric patients with cardiovascular disease. 20:27–37

go back to reference Sasso JP, Eves ND, Christensen JF, Koelwyn GJ, Scott J, Jones LW (2015) A framework for prescription in exercise-oncology research. J Cachexia Sarcopenia Muscle 6:115–124CrossRefPubMedPubMedCentral Sasso JP, Eves ND, Christensen JF, Koelwyn GJ, Scott J, Jones LW (2015) A framework for prescription in exercise-oncology research. J Cachexia Sarcopenia Muscle 6:115–124CrossRefPubMedPubMedCentral

go back to reference van Brussel M, Takken T, Lucia A, van der Net J, Helders PJ (2005) Is physical fitness decreased in survivors of childhood leukemia? A systematic review. Leukemia 19:13–17CrossRefPubMed van Brussel M, Takken T, Lucia A, van der Net J, Helders PJ (2005) Is physical fitness decreased in survivors of childhood leukemia? A systematic review. Leukemia 19:13–17CrossRefPubMed

go back to reference Matthys D, Verhaaren H, Benoit Y, Laureys G, De Naeyer A, Craen M (1993) Gender difference in aerobic capacity in adolescents after cure from malignant disease in childhood. Acta Paediatr 82:459–462CrossRefPubMed Matthys D, Verhaaren H, Benoit Y, Laureys G, De Naeyer A, Craen M (1993) Gender difference in aerobic capacity in adolescents after cure from malignant disease in childhood. Acta Paediatr 82:459–462CrossRefPubMed

go back to reference Chamorro-Vina C, Keats MR, Culos-Reed NS (2015) Pediatric Oncology Exercise Manual Chamorro-Vina C, Keats MR, Culos-Reed NS (2015) Pediatric Oncology Exercise Manual

go back to reference Chen JJ, Wu PT, Middlekauff HR, Nguyen KL (2017) Aerobic exercise in anthracycline-induced cardiotoxicity: a systematic review of current evidence and future directions. Am J Physiol Heart Circ Physiol 312:H213–H222CrossRefPubMed Chen JJ, Wu PT, Middlekauff HR, Nguyen KL (2017) Aerobic exercise in anthracycline-induced cardiotoxicity: a systematic review of current evidence and future directions. Am J Physiol Heart Circ Physiol 312:H213–H222CrossRefPubMed

go back to reference Jones LW, Liang Y, Pituskin EN, Battaglini CL, Scott JM, Hornsby WE, Haykowsky M (2011) Effect of exercise training on peak oxygen consumption in patients with cancer: a meta-analysis. Oncologist 16:112–120CrossRefPubMedPubMedCentral Jones LW, Liang Y, Pituskin EN, Battaglini CL, Scott JM, Hornsby WE, Haykowsky M (2011) Effect of exercise training on peak oxygen consumption in patients with cancer: a meta-analysis. Oncologist 16:112–120CrossRefPubMedPubMedCentral

go back to reference Beaudry R (2015) Effect of supervised exercise on aerobic capacity in cancer survivors: adherence and workload predict variance in effect. 3:43 Beaudry R (2015) Effect of supervised exercise on aerobic capacity in cancer survivors: adherence and workload predict variance in effect. 3:43

go back to reference Liu RD, Chinapaw MJ, Huijgens PC, van Mechelen W (2009) Physical exercise interventions in haematological cancer patients, feasible to conduct but effectiveness to be established: a systematic literature review. Cancer Treat Rev 35:185–192CrossRefPubMed Liu RD, Chinapaw MJ, Huijgens PC, van Mechelen W (2009) Physical exercise interventions in haematological cancer patients, feasible to conduct but effectiveness to be established: a systematic literature review. Cancer Treat Rev 35:185–192CrossRefPubMed

go back to reference Braam KI, van der Torre P, Takken T, Veening MA, van Dulmen-den Broeder E, Kaspers GJ (2016) Physical exercise training interventions for children and young adults during and after treatment for childhood cancer. Cochrane Database Syst Rev 3:CD008796PubMed Braam KI, van der Torre P, Takken T, Veening MA, van Dulmen-den Broeder E, Kaspers GJ (2016) Physical exercise training interventions for children and young adults during and after treatment for childhood cancer. Cochrane Database Syst Rev 3:CD008796PubMed

go back to reference Moug SJ, Bryce A, Mutrie N, Anderson AS (2017) Lifestyle interventions are feasible in patients with colorectal cancer with potential short-term health benefits: a systematic review. Int J Color Dis 32:765–775CrossRef Moug SJ, Bryce A, Mutrie N, Anderson AS (2017) Lifestyle interventions are feasible in patients with colorectal cancer with potential short-term health benefits: a systematic review. Int J Color Dis 32:765–775CrossRef

go back to reference Flynn KE, Pina IL, Whellan DJ, Lin L, Blumenthal JA, Ellis SJ, Fine LJ, Howlett JG, Keteyian SJ, Kitzman DW, Kraus WE, Miller NH, Schulman KA, Spertus JA, O'Connor CM, Weinfurt KP, HF-ACTION Investigators (2009) Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA 301:1451–1459CrossRefPubMedPubMedCentral Flynn KE, Pina IL, Whellan DJ, Lin L, Blumenthal JA, Ellis SJ, Fine LJ, Howlett JG, Keteyian SJ, Kitzman DW, Kraus WE, Miller NH, Schulman KA, Spertus JA, O'Connor CM, Weinfurt KP, HF-ACTION Investigators (2009) Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA 301:1451–1459CrossRefPubMedPubMedCentral

go back to reference Tukenova M, Guibout C, Oberlin O, Doyon F, Mousannif A, Haddy N, Guerin S, Pacquement H, Aouba A, Hawkins M, Winter D, Bourhis J, Lefkopoulos D, Diallo I, de Vathaire F (2010) Role of cancer treatment in long-term overall and cardiovascular mortality after childhood cancer. J Clin Oncol 28:1308–1315CrossRefPubMed Tukenova M, Guibout C, Oberlin O, Doyon F, Mousannif A, Haddy N, Guerin S, Pacquement H, Aouba A, Hawkins M, Winter D, Bourhis J, Lefkopoulos D, Diallo I, de Vathaire F (2010) Role of cancer treatment in long-term overall and cardiovascular mortality after childhood cancer. J Clin Oncol 28:1308–1315CrossRefPubMed

go back to reference Pescatello LS (2014) Interpretation of clinical exercise test results. In: Anonymous ACSM’s guidelines for exercise testing and prescription, 9th ed. edn. Wolters Kluwer/Lippincott Williams & Wilkins Health., Philadelphia, pp 241–266 Pescatello LS (2014) Interpretation of clinical exercise test results. In: Anonymous ACSM’s guidelines for exercise testing and prescription, 9th ed. edn. Wolters Kluwer/Lippincott Williams & Wilkins Health., Philadelphia, pp 241–266

go back to reference Hutton B, Moher D, Cameron C (2015) The PRISMA extension statement. Ann Intern Med 163:566–567CrossRefPubMed Hutton B, Moher D, Cameron C (2015) The PRISMA extension statement. Ann Intern Med 163:566–567CrossRefPubMed

go back to reference Higgins JPT, Altman DG, Sterne JAC (2011) Assessing risk of bias in included studies. In: Higgins JPT, Green S (eds) Cochrane handbook for systematic reviews of interventions. 5.1.0 [updated march 2011] The Cochrane Collaboration Higgins JPT, Altman DG, Sterne JAC (2011) Assessing risk of bias in included studies. In: Higgins JPT, Green S (eds) Cochrane handbook for systematic reviews of interventions. 5.1.0 [updated march 2011] The Cochrane Collaboration

go back to reference The Cochrane Collaboration (2014) Review Manager (RevMan) The Cochrane Collaboration (2014) Review Manager (RevMan)

go back to reference Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629–634CrossRefPubMedPubMedCentral Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629–634CrossRefPubMedPubMedCentral

go back to reference Schunemann H, Brozek J, Guyatt G, Oxman A (2013) GRADE Handbook Schunemann H, Brozek J, Guyatt G, Oxman A (2013) GRADE Handbook

go back to reference Dubnov-Raz G, Azar M, Reuveny R, Katz U, Weintraub M, Constantini NW (2015) Changes in fitness are associated with changes in body composition and bone health in children after cancer. Acta Paediatr 104:1055–1061CrossRefPubMed Dubnov-Raz G, Azar M, Reuveny R, Katz U, Weintraub M, Constantini NW (2015) Changes in fitness are associated with changes in body composition and bone health in children after cancer. Acta Paediatr 104:1055–1061CrossRefPubMed

go back to reference Shore S (1998) The effect of a moderate aerobic training program on T.B. and natural killer cell function in normal adults, normal children, and children with cancer. Dissertation. University of Toronto. Shore S (1998) The effect of a moderate aerobic training program on T.B. and natural killer cell function in normal adults, normal children, and children with cancer. Dissertation. University of Toronto.

go back to reference Braam KI, van Dijk EM, Veening MA, Bierings MB, Merks JH, Grootenhuis MA, Chinapaw MJ, Sinnema G, Takken T, Huisman J, Kaspers GJ, van Dulmen-den Broeder E (2010) Design of the Quality of Life in Motion (QLIM) study: a randomized controlled trial to evaluate the effectiveness and cost-effectiveness of a combined physical exercise and psychosocial training program to improve physical fitness in children with cancer. BMC Cancer 10:624–2407–10-624 Braam KI, van Dijk EM, Veening MA, Bierings MB, Merks JH, Grootenhuis MA, Chinapaw MJ, Sinnema G, Takken T, Huisman J, Kaspers GJ, van Dulmen-den Broeder E (2010) Design of the Quality of Life in Motion (QLIM) study: a randomized controlled trial to evaluate the effectiveness and cost-effectiveness of a combined physical exercise and psychosocial training program to improve physical fitness in children with cancer. BMC Cancer 10:624–2407–10-624

go back to reference Soares-Miranda L, Fiuza-Luces C, Lassaletta A, Santana-Sosa E, Padilla JR, Fernandez-Casanova L, Lorenzo-Gonzalez R, Lopez-Mojares LM, Perez M, Perez-Martinez A, Lucia A (2013) Physical Activity in Pediatric Cancer patients with solid tumors (PAPEC): trial rationale and design. Contemp Clin Trials 36:106–115CrossRefPubMed Soares-Miranda L, Fiuza-Luces C, Lassaletta A, Santana-Sosa E, Padilla JR, Fernandez-Casanova L, Lorenzo-Gonzalez R, Lopez-Mojares LM, Perez M, Perez-Martinez A, Lucia A (2013) Physical Activity in Pediatric Cancer patients with solid tumors (PAPEC): trial rationale and design. Contemp Clin Trials 36:106–115CrossRefPubMed

go back to reference Marchese VG, Chiarello LA, Lange BJ (2004) Effects of physical therapy intervention for children with acute lymphoblastic leukemia. Pediatr Blood Cancer 42:127–133CrossRefPubMed Marchese VG, Chiarello LA, Lange BJ (2004) Effects of physical therapy intervention for children with acute lymphoblastic leukemia. Pediatr Blood Cancer 42:127–133CrossRefPubMed

go back to reference Moyer-Mileur LJ, Ransdell L, Bruggers CS (2009) Fitness of children with standard-risk acute lymphoblastic leukemia during maintenance therapy: response to a home-based exercise and nutrition program. J Pediatr Hematol Oncol 31:259–266CrossRefPubMed Moyer-Mileur LJ, Ransdell L, Bruggers CS (2009) Fitness of children with standard-risk acute lymphoblastic leukemia during maintenance therapy: response to a home-based exercise and nutrition program. J Pediatr Hematol Oncol 31:259–266CrossRefPubMed

go back to reference Tanir MK, Kuguoglu S (2013) Impact of exercise on lower activity levels in children with acute lymphoblastic leukemia: a randomized controlled trial from Turkey. Rehabil Nurs 38:48–59CrossRefPubMed Tanir MK, Kuguoglu S (2013) Impact of exercise on lower activity levels in children with acute lymphoblastic leukemia: a randomized controlled trial from Turkey. Rehabil Nurs 38:48–59CrossRefPubMed

go back to reference Chiang YC (2007) The effects of a home-based aerobic exercise intervention on fatigue and cardiorespiratory fitness in children with acute lymphoblastic leukemia during the maintenance stage of chemotherapy. Chang Gung University Chiang YC (2007) The effects of a home-based aerobic exercise intervention on fatigue and cardiorespiratory fitness in children with acute lymphoblastic leukemia during the maintenance stage of chemotherapy. Chang Gung University

go back to reference Niesen-Vertommen S (1998) The recovery patterns and effects of exercise rehabilitation on the physiological and psychological health of children who have survived treatment for a malignancy. University of British Columbia Niesen-Vertommen S (1998) The recovery patterns and effects of exercise rehabilitation on the physiological and psychological health of children who have survived treatment for a malignancy. University of British Columbia

go back to reference Braam K, Van Dijk-Lokkart EM, Takken T, Veening MA, Huisman J (2014) Short term effects on physical fitness of a 12-week exercise and psychosocial training program in childhood cancer patients. 61:S242–243 Braam K, Van Dijk-Lokkart EM, Takken T, Veening MA, Huisman J (2014) Short term effects on physical fitness of a 12-week exercise and psychosocial training program in childhood cancer patients. 61:S242–243

go back to reference Winningham ML (1991) Walking program for people with cancer. Getting started. Cancer Nurs 14:270–276CrossRefPubMed Winningham ML (1991) Walking program for people with cancer. Getting started. Cancer Nurs 14:270–276CrossRefPubMed

go back to reference Higgins J, Green S (2011) Cochrane Handbook for Systematic Reviews of Interventions Higgins J, Green S (2011) Cochrane Handbook for Systematic Reviews of Interventions

go back to reference Lefrak EA, Pitha J, Rosenheim S, Gottlieb JA (1973) A clinicopathologic analysis of adriamycin cardiotoxicity. Cancer 32:302–314CrossRefPubMed Lefrak EA, Pitha J, Rosenheim S, Gottlieb JA (1973) A clinicopathologic analysis of adriamycin cardiotoxicity. Cancer 32:302–314CrossRefPubMed

go back to reference Rushton M, Clark R, Brideson G, Damarell R (2015) The effectiveness of non-pharmacological interventions for the management of cancer treatment-induced cardiotoxicity: a systematic review protocol. JBI Database System Rev Implement Rep 13:53–73PubMed Rushton M, Clark R, Brideson G, Damarell R (2015) The effectiveness of non-pharmacological interventions for the management of cancer treatment-induced cardiotoxicity: a systematic review protocol. JBI Database System Rev Implement Rep 13:53–73PubMed

go back to reference Laukkanen JA, Kurl S, Salonen R, Rauramaa R, Salonen JT (2004) The predictive value of cardiorespiratory fitness for cardiovascular events in men with various risk profiles: a prospective population-based cohort study. Eur Heart J 25:1428–1437CrossRefPubMed Laukkanen JA, Kurl S, Salonen R, Rauramaa R, Salonen JT (2004) The predictive value of cardiorespiratory fitness for cardiovascular events in men with various risk profiles: a prospective population-based cohort study. Eur Heart J 25:1428–1437CrossRefPubMed

go back to reference Kavanagh T, Mertens DJ, Hamm LF, Beyene J, Kennedy J, Corey P, Shephard RJ (2003) Peak oxygen intake and cardiac mortality in women referred for cardiac rehabilitation. J Am Coll Cardiol 42:2139–2143CrossRefPubMed Kavanagh T, Mertens DJ, Hamm LF, Beyene J, Kennedy J, Corey P, Shephard RJ (2003) Peak oxygen intake and cardiac mortality in women referred for cardiac rehabilitation. J Am Coll Cardiol 42:2139–2143CrossRefPubMed

go back to reference Kavanagh T, Mertens DJ, Hamm LF, Beyene J, Kennedy J, Corey P, Shephard RJ (2002) Prediction of long-term prognosis in 12 169 men referred for cardiac rehabilitation. Circulation 106:666–671CrossRefPubMed Kavanagh T, Mertens DJ, Hamm LF, Beyene J, Kennedy J, Corey P, Shephard RJ (2002) Prediction of long-term prognosis in 12 169 men referred for cardiac rehabilitation. Circulation 106:666–671CrossRefPubMed

go back to reference Kodama S, Saito K, Tanaka S, Maki M, Yachi Y, Asumi M, Sugawara A, Totsuka K, Shimano H, Ohashi Y, Yamada N, Sone H (2009) Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis. JAMA 301:2024–2035CrossRefPubMed Kodama S, Saito K, Tanaka S, Maki M, Yachi Y, Asumi M, Sugawara A, Totsuka K, Shimano H, Ohashi Y, Yamada N, Sone H (2009) Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis. JAMA 301:2024–2035CrossRefPubMed

go back to reference Payne VG, Morrow JR Jr (1993) Exercise and VO2 max in children: a meta-analysis. Res Q Exerc Sport 64:305–313CrossRefPubMed Payne VG, Morrow JR Jr (1993) Exercise and VO2 max in children: a meta-analysis. Res Q Exerc Sport 64:305–313CrossRefPubMed

go back to reference Sharkey AM, Carey AB, Heise CT, Barber G (1993) Cardiac rehabilitation after cancer therapy in children and young adults. Am J Cardiol 71:1488–1490CrossRefPubMed Sharkey AM, Carey AB, Heise CT, Barber G (1993) Cardiac rehabilitation after cancer therapy in children and young adults. Am J Cardiol 71:1488–1490CrossRefPubMed

go back to reference Hinkle AS, Proukou C, Chen Y (2005) Pulmonary effects of antineoplastic therapy. In: Schwartz CL, Hobbie WL, Constine LS, Ruccione KS (eds) Survivors of childhood cancer and adolescent cancer, 2nd edn. Springer, Berlin, pp 161–180CrossRef Hinkle AS, Proukou C, Chen Y (2005) Pulmonary effects of antineoplastic therapy. In: Schwartz CL, Hobbie WL, Constine LS, Ruccione KS (eds) Survivors of childhood cancer and adolescent cancer, 2nd edn. Springer, Berlin, pp 161–180CrossRef

go back to reference Ness KK, Armenian SH, Kadan-Lottick N, Gurney JG (2011) Adverse effects of treatment in childhood acute lymphoblastic leukemia: general overview and implications for long-term cardiac health. Expert Rev Hematol 4:185–197CrossRefPubMedPubMedCentral Ness KK, Armenian SH, Kadan-Lottick N, Gurney JG (2011) Adverse effects of treatment in childhood acute lymphoblastic leukemia: general overview and implications for long-term cardiac health. Expert Rev Hematol 4:185–197CrossRefPubMedPubMedCentral

go back to reference Sontgerath R, Eckert K (2015) Impairments of lower extremity muscle strength and balance in childhood cancer patients and survivors: a systematic review. Pediatr Hematol Oncol 32:585–612CrossRefPubMed Sontgerath R, Eckert K (2015) Impairments of lower extremity muscle strength and balance in childhood cancer patients and survivors: a systematic review. Pediatr Hematol Oncol 32:585–612CrossRefPubMed

go back to reference Scott JM, Khakoo A, Mackey JR, Haykowsky MJ, Douglas PS, Jones LW (2011) Modulation of anthracycline-induced cardiotoxicity by aerobic exercise in breast cancer: current evidence and underlying mechanisms. Circulation 124:642–650CrossRefPubMedPubMedCentral Scott JM, Khakoo A, Mackey JR, Haykowsky MJ, Douglas PS, Jones LW (2011) Modulation of anthracycline-induced cardiotoxicity by aerobic exercise in breast cancer: current evidence and underlying mechanisms. Circulation 124:642–650CrossRefPubMedPubMedCentral

go back to reference Shirinbayan V, Roshan VD (2012) Pretreatment effect of running exercise on HSP70 and DOX-induced cardiotoxicity. Asian Pac J Cancer Prev 13:5849–5855CrossRefPubMed Shirinbayan V, Roshan VD (2012) Pretreatment effect of running exercise on HSP70 and DOX-induced cardiotoxicity. Asian Pac J Cancer Prev 13:5849–5855CrossRefPubMed

go back to reference Ashrafi J (2012) Cardioprotective effects of aerobic regular exercise against doxorubicin-induced oxidative stress in rats. 6:2380–2388 Ashrafi J (2012) Cardioprotective effects of aerobic regular exercise against doxorubicin-induced oxidative stress in rats. 6:2380–2388

go back to reference Dimeo F, Fetscher S, Lange W, Mertelsmann R, Keul J (1997) Effects of aerobic exercise on the physical performance and incidence of treatment-related complications after high-dose chemotherapy. Blood 90:3390–3394PubMed Dimeo F, Fetscher S, Lange W, Mertelsmann R, Keul J (1997) Effects of aerobic exercise on the physical performance and incidence of treatment-related complications after high-dose chemotherapy. Blood 90:3390–3394PubMed

go back to reference Haykowsky MJ, Mackey JR, Thompson RB, Jones LW, Paterson DI (2009) Adjuvant trastuzumab induces ventricular remodeling despite aerobic exercise training. Clin Cancer Res 15:4963–4967CrossRefPubMed Haykowsky MJ, Mackey JR, Thompson RB, Jones LW, Paterson DI (2009) Adjuvant trastuzumab induces ventricular remodeling despite aerobic exercise training. Clin Cancer Res 15:4963–4967CrossRefPubMed

go back to reference Huang C, Zhang X, Ramil JM, Rikka S, Kim L, Lee Y, Gude NA, Thistlethwaite PA, Sussman MA, Gottlieb RA, Gustafsson AB (2010) Juvenile exposure to anthracyclines impairs cardiac progenitor cell function and vascularization resulting in greater susceptibility to stress-induced myocardial injury in adult mice. Circulation 121:675–683CrossRefPubMedPubMedCentral Huang C, Zhang X, Ramil JM, Rikka S, Kim L, Lee Y, Gude NA, Thistlethwaite PA, Sussman MA, Gottlieb RA, Gustafsson AB (2010) Juvenile exposure to anthracyclines impairs cardiac progenitor cell function and vascularization resulting in greater susceptibility to stress-induced myocardial injury in adult mice. Circulation 121:675–683CrossRefPubMedPubMedCentral

go back to reference Scheede-Bergdahl C, Jagoe RT (2013) After the chemotherapy: potential mechanisms for chemotherapy-induced delayed skeletal muscle dysfunction in survivors of acute lymphoblastic leukaemia in childhood. Front Pharmacol 4:49CrossRefPubMedPubMedCentral Scheede-Bergdahl C, Jagoe RT (2013) After the chemotherapy: potential mechanisms for chemotherapy-induced delayed skeletal muscle dysfunction in survivors of acute lymphoblastic leukaemia in childhood. Front Pharmacol 4:49CrossRefPubMedPubMedCentral

go back to reference Buffart LM, Galvao DA, Brug J, Chinapaw MJ, Newton RU (2014) Evidence-based physical activity guidelines for cancer survivors: current guidelines, knowledge gaps and future research directions. Cancer Treat Rev 40:327–340CrossRefPubMed Buffart LM, Galvao DA, Brug J, Chinapaw MJ, Newton RU (2014) Evidence-based physical activity guidelines for cancer survivors: current guidelines, knowledge gaps and future research directions. Cancer Treat Rev 40:327–340CrossRefPubMed

go back to reference Courneya KS, McKenzie DC, Mackey JR, Gelmon K, Friedenreich CM, Yasui Y, Reid RD, Cook D, Jespersen D, Proulx C, Dolan LB, Forbes CC, Wooding E, Trinh L, Segal RJ (2013) Effects of exercise dose and type during breast cancer chemotherapy: multicenter randomized trial. J Natl Cancer Inst 105:1821–1832CrossRefPubMed Courneya KS, McKenzie DC, Mackey JR, Gelmon K, Friedenreich CM, Yasui Y, Reid RD, Cook D, Jespersen D, Proulx C, Dolan LB, Forbes CC, Wooding E, Trinh L, Segal RJ (2013) Effects of exercise dose and type during breast cancer chemotherapy: multicenter randomized trial. J Natl Cancer Inst 105:1821–1832CrossRefPubMed

go back to reference Courneya KS, McKenzie DC, Mackey JR, Gelmon K, Friedenreich CM, Yasui Y, Reid RD, Vallerand JR, Adams SC, Proulx C, Dolan LB, Wooding E, Segal RJ (2014) Subgroup effects in a randomised trial of different types and doses of exercise during breast cancer chemotherapy. Br J Cancer 111:1718–1725CrossRefPubMedPubMedCentral Courneya KS, McKenzie DC, Mackey JR, Gelmon K, Friedenreich CM, Yasui Y, Reid RD, Vallerand JR, Adams SC, Proulx C, Dolan LB, Wooding E, Segal RJ (2014) Subgroup effects in a randomised trial of different types and doses of exercise during breast cancer chemotherapy. Br J Cancer 111:1718–1725CrossRefPubMedPubMedCentral

go back to reference Burnham TR, Wilcox A (2002) Effects of exercise on physiological and psychological variables in cancer survivors. Med Sci Sports Exerc 34:1863–1867CrossRefPubMed Burnham TR, Wilcox A (2002) Effects of exercise on physiological and psychological variables in cancer survivors. Med Sci Sports Exerc 34:1863–1867CrossRefPubMed

go back to reference Buffart LM, Kalter J, Sweegers MG, Courneya KS, Newton RU, Aaronson NK, Jacobsen PB, May AM, Galvão DA, Chinapaw MJ, Steindorf K, Irwin ML, Stuiver MM, Hayes S, Griffith KA, Lucia A, Mesters I, van Weert E, Knoop H, Goedendorp MM, Mutrie N, Daley AJ, McConnachie A, Bohus M, Thorsen L, Schulz KH, Short CE, James EL, Plotnikoff RC, Arbane G, Schmidt ME, Potthoff K, van Beurden M, Oldenburg HS, Sonke GS, van Harten WH, Garrod R, Schmitz KH, Winters-Stone KM, Velthuis MJ, Taaffe DR, van Mechelen W, Kersten MJ, Nollet F, Wenzel J, Wiskemann J, Verdonck-de Leeuw IM, Brug J (2017) Effects and moderators of exercise on quality of life and physical function in patients with cancer: an individual patient data meta-analysis of 34 RCTs. Cancer Treat Rev 52:91–104CrossRefPubMed Buffart LM, Kalter J, Sweegers MG, Courneya KS, Newton RU, Aaronson NK, Jacobsen PB, May AM, Galvão DA, Chinapaw MJ, Steindorf K, Irwin ML, Stuiver MM, Hayes S, Griffith KA, Lucia A, Mesters I, van Weert E, Knoop H, Goedendorp MM, Mutrie N, Daley AJ, McConnachie A, Bohus M, Thorsen L, Schulz KH, Short CE, James EL, Plotnikoff RC, Arbane G, Schmidt ME, Potthoff K, van Beurden M, Oldenburg HS, Sonke GS, van Harten WH, Garrod R, Schmitz KH, Winters-Stone KM, Velthuis MJ, Taaffe DR, van Mechelen W, Kersten MJ, Nollet F, Wenzel J, Wiskemann J, Verdonck-de Leeuw IM, Brug J (2017) Effects and moderators of exercise on quality of life and physical function in patients with cancer: an individual patient data meta-analysis of 34 RCTs. Cancer Treat Rev 52:91–104CrossRefPubMed

go back to reference Christiansen JR, Kanellopoulos A, Lund MB, Massey R, Dalen H, Kiserud CE, Ruud E, Aakhus S (2015) Impaired exercise capacity and left ventricular function in long-term adult survivors of childhood acute lymphoblastic leukemia. Pediatr Blood Cancer 62:1437–1443CrossRefPubMed Christiansen JR, Kanellopoulos A, Lund MB, Massey R, Dalen H, Kiserud CE, Ruud E, Aakhus S (2015) Impaired exercise capacity and left ventricular function in long-term adult survivors of childhood acute lymphoblastic leukemia. Pediatr Blood Cancer 62:1437–1443CrossRefPubMed

go back to reference Martin JE, Dubbert PM (1985) Adherence to exercise. Exerc Sport Sci Rev 13:137-168CrossRef Martin JE, Dubbert PM (1985) Adherence to exercise. Exerc Sport Sci Rev 13:137-168CrossRef