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Supportive Care in Cancer
Published in: Supportive Care in Cancer 9/2018

Open Access 01-09-2018 | Original Article

Investigation of the optimal duration of bed rest in the supine position to reduce complications after lumbar puncture combined with intrathecal chemotherapy: a multicenter prospective randomized controlled trial

Authors: Juan Li, Xiaozhe Li, Xiuzhen Tong, Junru Liu, Beihui Huang, Meilan Chen, Lifen Kuang, Zhenhai Zhou, Duorong Xu

Published in: Supportive Care in Cancer | Issue 9/2018

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Abstract

Purpose

This randomized, open-label trial was conducted to investigate the optimal duration of bed rest after intrathecal chemotherapy to reduce the incidence of complications without increasing patients’ tolerance to long-term bed rest.

Methods

A total of 390 patients receiving intrathecal chemotherapy were randomly assigned 1:1:1 to undergo bed rest for 6, 8, or 10 h after intrathecal chemotherapy. The primary outcome was the rate of complications after intrathecal chemotherapy. The analysis was per protocol.

Results

A total of 359 patients among the 390 patients in our study completed follow-up with 120 patients in the 6-h group, 120 in the 8-h group, and 119 in the 10-h group. The complications among the three groups differed significantly (P = 0.005). The 6-h group had significantly more complications than the 8- (50, 41.7% vs 29, 24.2%, P = 0.004) and 10-h groups (50, 41.7% vs 31, 26.1%, P = 0.011), whereas the difference between the 8- and 10-h groups was not significant (29, 24.2% vs 31, 26.1%, P = 0.737).

Conclusions

The overall results support that the optimal time interval for bed rest in the supine position after intrathecal chemotherapy is 8 h. This trial is registered with the Chinese Clinical Trial Registry (number ChiCTR-IOR-17011671).
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Metadata
Title
Investigation of the optimal duration of bed rest in the supine position to reduce complications after lumbar puncture combined with intrathecal chemotherapy: a multicenter prospective randomized controlled trial
Authors
Juan Li
Xiaozhe Li
Xiuzhen Tong
Junru Liu
Beihui Huang
Meilan Chen
Lifen Kuang
Zhenhai Zhou
Duorong Xu
Publication date
01-09-2018
Publisher
Springer Berlin Heidelberg
Published in
Supportive Care in Cancer / Issue 9/2018
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-018-4142-0

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