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Supportive Care in Cancer

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01-10-2017 | Original Article

Nutritional status of allogeneic hematopoietic stem cell transplantation recipients: influencing risk factors and impact on survival

Authors: Amro Mohamed Sedky El-Ghammaz, Rima Ben Matoug, Maha Elzimaity, Nevine Mostafa

Published in: Supportive Care in Cancer | Issue 10/2017

Abstract

Purpose

Patients subjected to allogeneic hematopoietic stem cell transplantation (HSCT) are at increased nutritional risk which in turn may alter their outcome. For providing good nutritional care for patients, it is important to analyze risk factors influencing nutritional status during and after HSCT.

Methods

Fifty patients undergoing allogeneic HSCT were subjected to nutritional status assessment by using the patient-generated subjective global assessment (PG-SGA) at initial admission, day 30 and day 180.

Results

Two patients (4%) had malnutrition at admission, 36 (72%) at day 30, and 24 (48%) at day 180. At day 30, comorbidity index higher than 0 and fever lasting for more than 1 week had a significant impact on nutritional status (P = .004 and P = .006, respectively). Regarding day 180, comorbidity index higher than 0 and presence of ≥grade II acute gastrointestinal graft versus host disease (GI GVHD) significantly influenced nutritional status (P = .017 and P = .026, respectively). Well-nourished patients at admission and day 180 had a significantly higher overall survival (OS) in comparison to malnourished patients (P < .001 and P = .012, respectively). Nutritional status at admission and day 180 had a significant influence on OS in multivariate analysis (P = .039 and P = .032, respectively).

Conclusions

Allogeneic HSCT patients having high comorbidity index, developing prolonged fever, and experiencing ≥grade II acute GI GVHD suffer from worsening in their nutritional status during hospitalization and after discharge. Also, nutritional status at admission and day 180 significantly influences their survival.

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Title: Nutritional status of allogeneic hematopoietic stem cell transplantation recipients: influencing risk factors and impact on survival
Authors: Amro Mohamed Sedky El-Ghammaz
Rima Ben Matoug
Maha Elzimaity
Nevine Mostafa
Publication date: 01-10-2017
Publisher: Springer Berlin Heidelberg
Published in: Supportive Care in Cancer / Issue 10/2017
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-017-3716-6

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