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01-02-2017 | Review Article

A systematic review of oral herpetic viral infections in cancer patients: commonly used outcome measures and interventions

Authors: Sharon Elad, Vinisha Ranna, Anura Ariyawardana, Maria Elvira Pizzigatti Correa, Vanessa Tilly, Raj G Nair, Tanya Rouleau, Richard M Logan, Andres Pinto, Veronica Charette, Debbie P Saunders, Siri Beier Jensen, Viral Infections Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO)

Published in: Supportive Care in Cancer | Issue 2/2017

Abstract

Purpose

To review the literature for outcome measures for oral viral infections in cancer patients. A secondary aim was to update the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) clinical practice guidelines for the management of oral viral infections in cancer patients.

Methods

Databases were searched for articles published in the English language, 1981–2013. Studies that met the eligibility criteria were reviewed systematically. The data about the outcome measures were classified according to the aim of the study: prevention, treatment, or non-interventional. The results of interventional studies were compared to the 2010 MASCC/ISOO publication.

Results

Multiple clinical and laboratory tests were used to measure oral viral infections, with great variability between studies. Most of the studies were about Herpes Simplex Virus (HSV). The outcome measure that was most commonly used was the presence of HSV infection diagnosed based on a combination of suggestive clinical presentation with a positive laboratory result. HSV culture was the most commonly reported laboratory outcome measure. Acyclovir and valacyclovir were consistently reported to be efficacious in the management of oral herpetic infections. No new data on the quality of life and economic aspects was found.

Conclusions

Considering the variability in outcome measures reported to assess oral herpetic infections the researcher should select carefully the appropriate measures based on the objective of the study. Acyclovir and valacyclovir are effective in the management of oral herpetic infections in patients receiving treatment for cancer. Studies on newer anti-viral drugs may be useful to address the issue of anti-viral resistance.

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Title: A systematic review of oral herpetic viral infections in cancer patients: commonly used outcome measures and interventions
Authors: Sharon Elad
Vinisha Ranna
Anura Ariyawardana
Maria Elvira Pizzigatti Correa
Vanessa Tilly
Raj G Nair
Tanya Rouleau
Richard M Logan
Andres Pinto
Veronica Charette
Debbie P Saunders
Siri Beier Jensen
Viral Infections Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO)
Publication date: 01-02-2017
Publisher: Springer Berlin Heidelberg
Published in: Supportive Care in Cancer / Issue 2/2017
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-016-3477-7

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