Skip to main content
Top
Published in: Supportive Care in Cancer 1/2011

01-03-2011 | Special Article

Antiemetic therapy for multiple-day chemotherapy and additional topics consisting of rescue antiemetics and high-dose chemotherapy with stem cell transplant: review and consensus statement

Authors: Lawrence H. Einhorn, Steven M. Grunberg, Bernardo Rapoport, Cynthia Rittenberg, Petra Feyer

Published in: Supportive Care in Cancer | Special Issue 1/2011

Login to get access

Abstract

This paper will evaluate various topics related to chemotherapy-induced nausea and vomiting. The results published reflect a consensus conference convened in Perugia, Italy. The topics discussed include antiemetic therapy of multiple-day chemotherapy, high-dose chemotherapy, and rescue antiemetics.
Literature
1.
go back to reference Einhorn LH, Rapoport B, Koeller J et al (2005) Antiemetic therapy for multiple-day chemotherapy and high-dose chemotherapy with stem cell transplant: review and consensus statement. Supp Care Cancer 13:112–116CrossRef Einhorn LH, Rapoport B, Koeller J et al (2005) Antiemetic therapy for multiple-day chemotherapy and high-dose chemotherapy with stem cell transplant: review and consensus statement. Supp Care Cancer 13:112–116CrossRef
2.
go back to reference Somerfield MR, Einhaus K, Hagerty KL et al (2008) American society of clinical oncology clinical practice guidelines: opportunities and challenges. J Clin Oncol 26:4022–4026PubMedCrossRef Somerfield MR, Einhaus K, Hagerty KL et al (2008) American society of clinical oncology clinical practice guidelines: opportunities and challenges. J Clin Oncol 26:4022–4026PubMedCrossRef
3.
go back to reference Herman TS, Einhorn LH, Jones SE et al (1979) Superiority of Nabilone over prochlorperazine as antiemetics in patients receiving chemotherapy. N Eng J Med 300:1295–1297CrossRef Herman TS, Einhorn LH, Jones SE et al (1979) Superiority of Nabilone over prochlorperazine as antiemetics in patients receiving chemotherapy. N Eng J Med 300:1295–1297CrossRef
4.
go back to reference Einhorn LH, Nagy C, Werner K et al (1990) Ondansetron: a new antiemetic for patients receiving cisplatin chemotherapy. J Clin Oncol 8:731–735PubMed Einhorn LH, Nagy C, Werner K et al (1990) Ondansetron: a new antiemetic for patients receiving cisplatin chemotherapy. J Clin Oncol 8:731–735PubMed
5.
go back to reference Fox SM, Einhorn LH, Cox E et al (1993) Ondansetron versus ondansetron, dexamethasone and chlorpromazine in the prevention of nausea and vomiting associated with multiple-day cisplatin chemotherapy. J Clin Oncol 11:2391–2395PubMed Fox SM, Einhorn LH, Cox E et al (1993) Ondansetron versus ondansetron, dexamethasone and chlorpromazine in the prevention of nausea and vomiting associated with multiple-day cisplatin chemotherapy. J Clin Oncol 11:2391–2395PubMed
6.
go back to reference Sledge GW, Einhorn LH, Nagy C et al (1992) Phase III double-blind comparison of intravenous ondansetron and metoclopramide as antiemetic therapy for patients receiving multiple-day cisplatin-based chemotherapy. Cancer 70:2524–2528PubMedCrossRef Sledge GW, Einhorn LH, Nagy C et al (1992) Phase III double-blind comparison of intravenous ondansetron and metoclopramide as antiemetic therapy for patients receiving multiple-day cisplatin-based chemotherapy. Cancer 70:2524–2528PubMedCrossRef
7.
go back to reference Einhorn LH, Brames MJ, Dreicer R et al (2007) Palonosetron plus dexamethasone for prevention of chemotherapy-induced nausea and vomiting in patients receiving multiple-day cisplatin chemotherapy for germ cell cancer. Supp Care Cancer 15:1293–1300CrossRef Einhorn LH, Brames MJ, Dreicer R et al (2007) Palonosetron plus dexamethasone for prevention of chemotherapy-induced nausea and vomiting in patients receiving multiple-day cisplatin chemotherapy for germ cell cancer. Supp Care Cancer 15:1293–1300CrossRef
8.
go back to reference Jordan K, Kinitz I, Voigt W et al (2009) Safety and efficacy of a triple antiemetic combination with the NK-1 antagonist aprepitant in highly and moderately emetogenic multiple-day chemotherapy. Eur J Cancer 45:1184–1187PubMedCrossRef Jordan K, Kinitz I, Voigt W et al (2009) Safety and efficacy of a triple antiemetic combination with the NK-1 antagonist aprepitant in highly and moderately emetogenic multiple-day chemotherapy. Eur J Cancer 45:1184–1187PubMedCrossRef
9.
go back to reference Brames MJ, Johnson E, Nichols C et al (2009) Phase III study of granisetron + dexamethasone +/− aprepitant in patients with germ cell tumors undergoing 5 day courses of cisplatin-based combination chemotherapy: a Hoosier Oncology Group (H.O.G.) study. Supp Care Cancer 17:871–872, abstract Brames MJ, Johnson E, Nichols C et al (2009) Phase III study of granisetron + dexamethasone +/− aprepitant in patients with germ cell tumors undergoing 5 day courses of cisplatin-based combination chemotherapy: a Hoosier Oncology Group (H.O.G.) study. Supp Care Cancer 17:871–872, abstract
10.
go back to reference Baltzer L, Pisters KMW, Kris MG et al (1993) High dose ondansetron plus dexamethasone for the prevention of nausea and vomiting with multiple day cisplatin chemotherapy. Proc Amer Soc Clin Oncol 12:462, abstract Baltzer L, Pisters KMW, Kris MG et al (1993) High dose ondansetron plus dexamethasone for the prevention of nausea and vomiting with multiple day cisplatin chemotherapy. Proc Amer Soc Clin Oncol 12:462, abstract
11.
go back to reference Vardy J, Chiew KS, Galica J, Pond GR, Tannock IF (2006) Side effects associated with the use of dexamethasone for prophylaxis of delayed emesis after moderately emetogenic chemotherapy. Brit J Cancer 94:1011–1015PubMedCrossRef Vardy J, Chiew KS, Galica J, Pond GR, Tannock IF (2006) Side effects associated with the use of dexamethasone for prophylaxis of delayed emesis after moderately emetogenic chemotherapy. Brit J Cancer 94:1011–1015PubMedCrossRef
12.
go back to reference Cook AM, Dzik-Jurasz Ask, Padhani AR, Norman A, Huddart RA (2001) The prevalence of avascular necrosis in patients treated with chemotherapy for testicular tumors. Brit J Cancer 85:1624–1626PubMedCrossRef Cook AM, Dzik-Jurasz Ask, Padhani AR, Norman A, Huddart RA (2001) The prevalence of avascular necrosis in patients treated with chemotherapy for testicular tumors. Brit J Cancer 85:1624–1626PubMedCrossRef
13.
go back to reference Ballen KK, Hesketh AM, Heyes C, Becker PS, Emmons RV, Fogarty K, LaPointe J, Liu Q, Hsieh CC, Hesketh PJ (2001) Prospective evaluation of antiemetic outcome following high-dose chemotherapy with hematopoietic stem cell support. Bone Marrow Transplant 28:1061–1066PubMedCrossRef Ballen KK, Hesketh AM, Heyes C, Becker PS, Emmons RV, Fogarty K, LaPointe J, Liu Q, Hsieh CC, Hesketh PJ (2001) Prospective evaluation of antiemetic outcome following high-dose chemotherapy with hematopoietic stem cell support. Bone Marrow Transplant 28:1061–1066PubMedCrossRef
14.
go back to reference López-Jiménez J, Martín-Ballesteros E, Sureda A, Uralburu C, Lorenzo I, del Campo R, Fernández C, Calbacho M, García-Belmonte D, Fernández G (2006) Chemotherapy-induced nausea and vomiting in acute leukemia and stem cell transplant patients: results of a multicenter, observational study. Haematologica 91:84–91PubMed López-Jiménez J, Martín-Ballesteros E, Sureda A, Uralburu C, Lorenzo I, del Campo R, Fernández C, Calbacho M, García-Belmonte D, Fernández G (2006) Chemotherapy-induced nausea and vomiting in acute leukemia and stem cell transplant patients: results of a multicenter, observational study. Haematologica 91:84–91PubMed
15.
go back to reference Mandanas RA, Beveridge R, Rifkin RM, Wallace H, Greenspan A, Asmar L (2005) A randomized, multicenter, open-label comparison of the antiemetic efficacy of dolasetron versus ondansetron for the prevention of nausea and vomiting during high-dose myeloablative chemotherapy. Support Cancer Ther 2:114–121PubMedCrossRef Mandanas RA, Beveridge R, Rifkin RM, Wallace H, Greenspan A, Asmar L (2005) A randomized, multicenter, open-label comparison of the antiemetic efficacy of dolasetron versus ondansetron for the prevention of nausea and vomiting during high-dose myeloablative chemotherapy. Support Cancer Ther 2:114–121PubMedCrossRef
16.
go back to reference Paul B, Trovato JA, Thompson J, Badros AZ, Goloubeva O (2009) Efficacy of aprepitant in patients receiving high-dose chemotherapy with hematopoietic stem cell support. J Oncol Pharm Pract 16:45–51PubMedCrossRef Paul B, Trovato JA, Thompson J, Badros AZ, Goloubeva O (2009) Efficacy of aprepitant in patients receiving high-dose chemotherapy with hematopoietic stem cell support. J Oncol Pharm Pract 16:45–51PubMedCrossRef
17.
go back to reference Musso M, Scalone R, Crescimanno A, Bonanno V, Polizzi V, Porretto F, Bianchini C, Perrone T (2009) Palonosetron and dexamethasone for prevention of nausea and vomiting in patients receiving high-dose chemotherapy with auto-SCT. Bone Marrow Transplant 45:123–127PubMedCrossRef Musso M, Scalone R, Crescimanno A, Bonanno V, Polizzi V, Porretto F, Bianchini C, Perrone T (2009) Palonosetron and dexamethasone for prevention of nausea and vomiting in patients receiving high-dose chemotherapy with auto-SCT. Bone Marrow Transplant 45:123–127PubMedCrossRef
18.
19.
go back to reference Choo SP, Kong KH, Lim WT, Gao F, Chua K, Leong SS (2006) Electroacupuncture for refractory acute emesis caused by chemotherapy. J Altern Complement Med 12:963–969PubMedCrossRef Choo SP, Kong KH, Lim WT, Gao F, Chua K, Leong SS (2006) Electroacupuncture for refractory acute emesis caused by chemotherapy. J Altern Complement Med 12:963–969PubMedCrossRef
20.
go back to reference Seynaeve C, de Mulder PH, Lane-Allman E, van Liessum PA, Verweij J (1991) The 5-HT3 receptor antagonist ondansetron re-establishes control in refractory emesis induced by non-cisplatin chemotherapy. Clin Oncol 3:199–203CrossRef Seynaeve C, de Mulder PH, Lane-Allman E, van Liessum PA, Verweij J (1991) The 5-HT3 receptor antagonist ondansetron re-establishes control in refractory emesis induced by non-cisplatin chemotherapy. Clin Oncol 3:199–203CrossRef
21.
go back to reference Fabi A, Ciccarese M, Metro G, Savarese A, Giannarelli D, Nuzzo CM, Russillo M, Sperduti I, Carbone I, Bria E, Cognetti F (2008) Oral ondansetron is highly active as rescue antiemetic treatment for moderately emetogenic chemotherapy: results of a randomized phase II study. Support Care Cancer 16:1375–1380PubMedCrossRef Fabi A, Ciccarese M, Metro G, Savarese A, Giannarelli D, Nuzzo CM, Russillo M, Sperduti I, Carbone I, Bria E, Cognetti F (2008) Oral ondansetron is highly active as rescue antiemetic treatment for moderately emetogenic chemotherapy: results of a randomized phase II study. Support Care Cancer 16:1375–1380PubMedCrossRef
22.
go back to reference Rojas J, Stathis M, Thomas AG, Massuda EB, Alt J, Zhang J, Rubenstein E, Sebastiani S, Cantoreggi S, Snyder SH, Slusher B (2008) Palonosetron exhibits unique molecular interactions with the 5-HT 3 receptor. Anesth Analg 107:469–478PubMedCrossRef Rojas J, Stathis M, Thomas AG, Massuda EB, Alt J, Zhang J, Rubenstein E, Sebastiani S, Cantoreggi S, Snyder SH, Slusher B (2008) Palonosetron exhibits unique molecular interactions with the 5-HT 3 receptor. Anesth Analg 107:469–478PubMedCrossRef
23.
go back to reference Hesketh PJ, Younger J, Sanz-Altamira P, Hayden M, Bushey J, Trainor B, Krentzin M, Nowd P, Arnaoutakis K, Hesketh AM (2009) Aprepitant as salvage antiemetic therapy in breast cancer patients receiving doxorubicin and cyclophosphamide. Support Care Cancer 17:1065–1070CrossRef Hesketh PJ, Younger J, Sanz-Altamira P, Hayden M, Bushey J, Trainor B, Krentzin M, Nowd P, Arnaoutakis K, Hesketh AM (2009) Aprepitant as salvage antiemetic therapy in breast cancer patients receiving doxorubicin and cyclophosphamide. Support Care Cancer 17:1065–1070CrossRef
24.
go back to reference Oechsle K, Muller MR, Hartmann JT, Kanz L, Bokemeyer C (2006) Aprepitant as salvage therapy in patients with chemotherapy-induced nausea and emesis refractory to prophylaxis with 5-HT3 antagonists and dexamethasone. Onkologie 19:557–561CrossRef Oechsle K, Muller MR, Hartmann JT, Kanz L, Bokemeyer C (2006) Aprepitant as salvage therapy in patients with chemotherapy-induced nausea and emesis refractory to prophylaxis with 5-HT3 antagonists and dexamethasone. Onkologie 19:557–561CrossRef
Metadata
Title
Antiemetic therapy for multiple-day chemotherapy and additional topics consisting of rescue antiemetics and high-dose chemotherapy with stem cell transplant: review and consensus statement
Authors
Lawrence H. Einhorn
Steven M. Grunberg
Bernardo Rapoport
Cynthia Rittenberg
Petra Feyer
Publication date
01-03-2011
Publisher
Springer-Verlag
Published in
Supportive Care in Cancer / Issue Special Issue 1/2011
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-010-0920-z

Other articles of this Special Issue 1/2011

Supportive Care in Cancer 1/2011 Go to the issue
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine