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Supportive Care in Cancer
Published in: Supportive Care in Cancer 1/2011

01-01-2011 | Original Article

Radiodermatitis prevention with sucralfate in breast cancer: fundamental and clinical studies

Authors: Sabrina Falkowski, Patrick Trouillas, Jean-Luc Duroux, Jean-Marie Bonnetblanc, Pierre Clavère

Published in: Supportive Care in Cancer | Issue 1/2011

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Abstract

Background

Acute radiodermatitis induced by radiotherapy may affect the quality of life and in some cases requires withholding treatment. The present study concerns the protective effect of a 1% sucralfate lotion. We propose joint fundamental and clinical points of view.

Methods

The free radical scavenging capacity of sucralfate was measured with electron spin resonance and was supported by theoretical calculations. The clinical effects of sucralfate lotion were evaluated on 21 women treated for breast cancer. Breast skin response was evaluated at 0, 10, 20, 30, 40, and 50 Gy, according to (1) the radiation therapy oncology group (RTOG) acute toxicity scale and (2) spectrophotometry data obtained with X-Rite SP60.

Results and conclusions

Sucralfate appeared as a relatively poor free radical scavenger (compared to reference compounds such as vitamin E). The sucralfate-containing lotion used in the present study did not provide systematic radiodermatitis prevention. Spectrophotometric evaluation of the skin response to irradiation appeared to be a very effective and more sensitive technique than the RTOG scale. Its use should be recommended to study cutaneous radioprotective action.
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Metadata
Title
Radiodermatitis prevention with sucralfate in breast cancer: fundamental and clinical studies
Authors
Sabrina Falkowski
Patrick Trouillas
Jean-Luc Duroux
Jean-Marie Bonnetblanc
Pierre Clavère
Publication date
01-01-2011
Publisher
Springer-Verlag
Published in
Supportive Care in Cancer / Issue 1/2011
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-009-0788-y

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