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Supportive Care in Cancer
Published in: Supportive Care in Cancer 5/2010

01-05-2010 | Original Article

Physical activity for men receiving androgen deprivation therapy for prostate cancer: benefits from a 16-week intervention

Authors: S. Nicole Culos-Reed, John W. Robinson, Harold Lau, Lynette Stephenson, Melanie Keats, Steve Norris, Greg Kline, Peter Faris

Published in: Supportive Care in Cancer | Issue 5/2010

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Abstract

Goals of work

Prostate cancer patients receiving androgen deprivation therapy (ADT) are vulnerable to a number of potentially debilitating side effects, which can significantly impact quality of life. The role of alternate therapies, such as physical activity (PA), in attenuating these side effects is largely understudied for such a large population. Thus, the purpose of this study was to investigate the effects of PA intervention for men receiving ADT on PA behavior, quality of life, and fitness measures.

Patients and methods

One hundred participants were randomized into an intervention (n = 53) or a wait-list control group (n = 47), with 11 dropping out of the intervention group and 23 dropping out of the wait-list control group prior to post-testing. The intervention consisted of both an individually tailored home-based aerobic and light resistant training program and weekly group sessions. PA, quality of life, fitness, and physiological outcomes were assessed pre and post the 16-week intervention.

Results

Significant increases in PA, supported by changes in girth measures and blood pressure, support the beneficial impact of the intervention. Positive trends were also evident for depression and fatigue. However, due to the high dropout rate, these results must be interpreted with caution.

Conclusions

PA effectively attenuates many of the side effects of ADT and should be recommended to prostate survivors as an alternate therapy. Determining the maintenance of this behavior change will be important for understanding how the long-term benefits of increased activity levels may alleviate the late effects of ADT.
Literature
1.
American Cancer Society (2006) Fact sheets: prostate cancer. ACS, Georgia
2.
National Cancer Institute of Canada (2006) Canadian cancer statistics 2006. NCIC, Ontario
3.
Baker F, Denniston M, Smith T, West MM (2005) Adult cancer survivors: how are they faring? Cancer 104(11 Suppl):2565–2576CrossRefPubMed
4.
Widmark A, Klepp O, Solberg A, Damber J-E, Angelsen A, Fransson P, Lund J-A, Tasdemir I, Hoyer M, Wildund F, Fossa S-D (2009) Endocrine treatment with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial. Lancet 373:301–308CrossRefPubMed
5.
Dacal K, Sereika SM, Greenspan SL (2006) Quality of life in prostate cancer patients taking androgen deprivation therapy. J Am Geriatr Soc 54:85–90CrossRefPubMed
6.
Eton DT, Lepore SJ (2002) Prostate cancer and health-related quality of life: a review of the literature. Psycho-oncology 11:307–326CrossRefPubMed
7.
Fowler FJ, Collins MM, Corkery EW, Elliott DB, Barry MJ (2002) The impact of androgen deprivation on quality of life after radical prostatectomy for prostate carcinoma. Cancer 95:287–295CrossRefPubMed
8.
Moyad MA (2005) Promoting general health during androgen deprivation therapy (ADT): a rapid 10-step review for your patients. Urol Oncol 23:56–64PubMed
9.
Dahn J, Penedo FJ, Molton I, Lopez L, Schneiderman N, Antoni MH (2005) Physical activity and sexual functioning after radiotherapy for prostate cancer: beneficial effects for patients undergoing external beam radiotherapy. Urology 65:953–958CrossRefPubMed
10.
Demark-Wahnefried W, Clipp EC, Morey MC, Pieper CF, Sloane R, Snyder DC et al (2004) Physical function and associations with diet and exercise: results of a cross-sectional survey among elders with breast or prostate cancer. Int J Behav Nutr Phys Act 1(1):16–21CrossRefPubMed
11.
Giovannucci EL, Liu Y, Leitzmann MF, Stampfer MJ, Willett WC (2005) A prospective study of physical activity and incident and fatal prostate cancer. Arch Intern Med 165:1005–1010CrossRefPubMed
12.
Ornish D, Weidner G, Fair WR, Marlin R, Pettengill EB, Raisin CJ et al (2005) Intensive lifestyle changes may affect the progression of prostate cancer. J Urol 174:1065–1070CrossRefPubMed
13.
Windsor PM, Nicol KF, Potter J (2004) A randomized, controlled trial of aerobic exercise for treatment-related fatigue in men receiving radical external beam radiotherapy for localized prostate carcinoma. Cancer 101:550–557CrossRefPubMed
14.
Segal RJ, Reid RD, Courneya KS, Malone SC, Parliament MB, Scott CG et al (2003) Resistance exercise in men receiving androgen deprivation therapy for prostate cancer. J Clin Oncol 21(9):1653–1659CrossRefPubMed
15.
Galvao DA, Nosaka K, Taaffe DR, Spry N, Kristjanson LJ, McGuigan MR, Suzuki K, Yamaya K, Newton RU (2006) Resistance training and reduction of treatment side effects in prostate cancer patients. Med Sci Sports Exerc 38:2045–2052CrossRefPubMed
16.
Galvao DA, Newton RU (2005) Review of exercise intervention studies in cancer patients. J Clin Oncol 23(4):899–909CrossRefPubMed
17.
McTiernan A (2004) Physical activity after cancer: physiologic outcomes. Cancer Invest 22(1):68–81CrossRefPubMed
18.
Stevinson C, Lawlor DA, Fox KR (2004) Exercise interventions for cancer patients: systematic review of controlled trials. Cancer Causes Control 2004(15):1035–1056CrossRef
19.
Bae DC, Stein BS (2004) The diagnosis and treatment of osteoporosis in men on androgen deprivation therapy for advanced carcinoma of the prostate. J Urol 172(6 Pt 1):2137–2144CrossRefPubMed
20.
Carron AV, Hausenblas HA, Mack D (1996) Social influence and exercise: a meta-analysis. J Sport Exerc Psychol 18:1–16
21.
McAuley E, Jerome GJ, Elavsky S, Marquez DX, Ramsey SN (2003) Predicting long-term maintenance of physical activity in older adults. Prev Med 37:110–118CrossRefPubMed
22.
Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ et al (1993) The European organization for research and treatment of cancer qlq-c30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85(5):365–376CrossRefPubMed
23.
Coates A, Porzsolt F, Osoba D (1997) Quality of life in oncology practice: prognostic value of eortc qlq-c30 scores in patients with advanced malignancy. Eur J Cancer 33(7):1025–1030CrossRefPubMed
24.
Joly F, Brune D, Couette JE, Lesaunier F, Heron JF, Peny J et al (1998) Health-related quality of life and sequelae in patients treated with brachytherapy and external beam irradiation for localized prostate cancer. Ann Oncol 9(7):751–757CrossRefPubMed
25.
Stone P, Richards M, A’Hern R, Hardy J (2001) Fatigue in patients with cancers of the breast or prostate undergoing radical radiotherapy. J Pain Symptom Manage 22:1007–1015CrossRefPubMed
26.
Wei JT, Dunn RL, Litwin MS, Sandler HM, Sanda MG (2000) Development and validation of the expanded prostate cancer index composite (EPIC) for comprehensive assessment of health-related quality of life in men with prostate cancer. Urology 56:899–905CrossRefPubMed
27.
Litwin MS, Hays RD, Fink A, Ganz PA, Leake B, Brook RH (1998) The UCLA prostate cancer index: development, reliability and validity of a health-related quality of life measurement. Med Care 1998(36):1002–1012CrossRef
28.
Stone P, Hardy R, Huddart R, A’Hern R, Richards M (2000) Fatigue in patients with prostate cancer receiving hormone therapy. Eur J Cancer 2000(36):1134–1141CrossRef
29.
McDowell I, Newell C (1996) Measuring health: a guide to rating scales and questionnaires, 2nd edn. Oxford University Press, New York
30.
Rejeski WJ, Brawley LR, Shumaker SA (1996) Physical activity and health-related quality of life. Exerc Sport Sci Rev 24:71–108CrossRefPubMed
31.
Godin G, Sheppard RJ (1985) A simple method to assess exercise behaviour in the community. Can J Appl Sport Sci 10:141–146PubMed
32.
Courneya KS, Friedenreich CM (1997) Relationship between exercise during cancer treatment and current quality of life in survivors of breast cancer. J Psychosoc Oncol 15(3/4):35–37
33.
Courneya KS, Friedenreich CM (1997) Relationship between exercise pattern across the cancer experience and current quality of life in colorectal cancer survivors. J Altern Complement Med 3(3):215–226CrossRefPubMed
34.
Jacobs DR, Ainsworth BE, Hartman TJ, Leon AS (1993) A simultaneous evaluation of ten commonly used physical activity questionnaires. Med Sci Sports Exerc 25:81–91CrossRefPubMed
35.
Canadian Society for Exercise Physiology (1998) The Canadian physical activity, fitness and lifestyle appraisal: CSEP’s guide to healthy active living. Health Canada, Ontario
36.
Schmitz KH, Holtzman J, Courneya KS, Masse LC, Duval S, Kane R (2005) Controlled PA trials in cancer survivors: a systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev 14(7):1588–1595CrossRefPubMed
37.
Oldervoll LM, Kaasa S, Hjermstad MJ, Lund JA, Loge JH (2003) Physical exercise results in the improved subjective well-being of a few or is effective rehabilitation for all cancer patients? Eur J Cancer 40:951–962CrossRef
38.
World Health Organization (1995) Physical status: the use and interpretation of anthropometry. WHO Technical Report Series, Geneva, Switzerland
39.
Brown JK, Byers T, Doyle C, Courneya K, Demark-Wahnefried W, Kushi LH et al (2003) Nutrition and physical activity during and after cancer treatment: an American Cancer Society guide for informed choices. CA Cancer J Clin 53:268–291CrossRefPubMed
40.
Courneya KS (2003) Exercise in cancer survivors: an overview of research. Med Sci Sports Exerc 35(11):1846–1852CrossRefPubMed
41.
Dimeo F, Rumberger BG, Keul J (1998) Aerobic exercise as therapy for cancer fatigue. Med Sci Sports Exerc 30(4):475–478PubMed
42.
Schwartz A (2004) Physical activity after cancer diagnosis: psychosocial outcomes. Cancer Invest 22(1):82–92CrossRefPubMed
43.
Kristal AR, Chi C, Tangen CM, Goodman PJ, Etzioni R, Thompson IM (2006) Associations of demographic and lifestyle characteristics with prostate-specific antigen (PSA) concentration and rate of PSA increase. Cancer 106:320–328CrossRefPubMed
44.
Penson D, Moul J, Gandhi S, Newling D (2006) Use of prostate-specific antigen in the follow-up of patients with localized prostate cancer: results of a nationwide survey of urologists. Urology 68(1):80–84CrossRefPubMed
45.
Ulman C, Buyukyazi G, Taneli F, Uyanik BS (2004) Recreational and master athletic activity does not affect free and total prostate-specific antigen levels but lowers the free-to-total prostate-specific antigen ratio. J Int Med Res 32(6):583–589PubMed
46.
Courneya KS, Friedenreich CM, Quinney HA, Fields AL, Jones LW, Fairey AS (2004) Predictors of adherence and contamination in a randomized trial of exercise in colorectal cancer survivors. Psycho-oncology 13(12):857–866CrossRefPubMed
47.
Courneya KS, Segal RJ, Reid RD, Jones LW, Malone SC, Venner PM et al (2004) Three independent factors predicted adherence in a randomized controlled trial of resistance exercise training among prostate cancer survivors. J Clin Epidemiol 57:571–579CrossRefPubMed
48.
Knols R, Aaronson NK, Uebelhart D, Fransen J, Aufdemkampe G (2005) Physical exercise in cancer patients during and after medical treatment: a systematic review of randomized and controlled clinical trials. J Clin Oncol 23(16):3830–3842CrossRefPubMed
49.
Wing RR (2000) Cross-cutting themes in maintenance of behaviour change. Health Psychol 19(Suppl):84–88CrossRefPubMed
50.
Alibhai SMH, Gogov S, Allibhai Z (2006) Long-term side effects of androgen deprivation therapy in men with non-metastatic prostate cancer: a systematic literature review. Crit Rev Oncol Hematol 60:201–215CrossRefPubMed
Metadata
Title
Physical activity for men receiving androgen deprivation therapy for prostate cancer: benefits from a 16-week intervention
Authors
S. Nicole Culos-Reed
John W. Robinson
Harold Lau
Lynette Stephenson
Melanie Keats
Steve Norris
Greg Kline
Peter Faris
Publication date
01-05-2010
Publisher
Springer-Verlag
Published in
Supportive Care in Cancer / Issue 5/2010
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-009-0694-3

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