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Supportive Care in Cancer

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01-06-2010 | Original Article

Nutritional support for head and neck cancer patients receiving radiotherapy: a systematic review

Authors: Shashank Garg, John Yoo, Eric Winquist

Published in: Supportive Care in Cancer | Issue 6/2010

Abstract

Purpose

Squamous cell carcinoma of the head and neck (HNSCC) is associated with weight loss before, during, and after treatment with radiotherapy (RT). This systematic review addressed the question “Which interventions aimed at optimizing nutrition are of benefit to HNSCC patients receiving RT?”

Methods

Randomized controlled trials (RCTs) studying interventions directed at nutritional support of adult patients with HNSCC receiving RT with or without chemotherapy were eligible. RCTs studying prophylaxis of acute mucositis, perioperative nutrition, or palliative and non-HNSCC populations were excluded. A comprehensive literature search was done and meta-analyses planned.

Results

Ten unique RCTs were identified (n = 585). All randomized less than 50 patients per trial arm. Five trials studied dietary counseling and/or nutritional supplements, four studied drug interventions, and one studied prophylactic enteral tube feeding. Nutritional status appeared to be maintained or improved with dietary counseling, megestrol acetate, and prophylactic enteral tube feeding.

Conclusions

Data from RCTs supporting the use of interventions to optimize nutrition in HNSCC patients receiving RT are limited in both quantity and quality. Potentially effective interventions have not been tested comparatively or in combination, and few patients receiving chemoradiotherapy were studied. Further research in this area is a priority.

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Title: Nutritional support for head and neck cancer patients receiving radiotherapy: a systematic review
Authors: Shashank Garg
John Yoo
Eric Winquist
Publication date: 01-06-2010
Publisher: Springer-Verlag
Published in: Supportive Care in Cancer / Issue 6/2010
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-009-0686-3

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