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Supportive Care in Cancer
Published in: Supportive Care in Cancer 2/2008

01-02-2008 | Review Article

Quality of life after surgery for colorectal cancer: clinical implications of results from randomised trials

Authors: Sameer Gujral, Kerry N. L. Avery, Jane M. Blazeby

Published in: Supportive Care in Cancer | Issue 2/2008

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Abstract

Goals of work

Health-related quality of life (HRQL) is an important outcome after surgery for colorectal cancer (CRC), and accurate assessment is required to fully inform clinical decision making. The purpose of this review is to summarise randomised surgical trials in CRC with robust HRQL to consider the role of HRQL in surgical decision making.

Materials and methods

A systematic review in Medline and the Cochrane Controlled Trials Register identified randomised surgical trials with HRQL. HRQL assessment was categorised as robust according to predefined criteria, and the clinical implications of HRQL were considered.

Main results

One hundred seventy-seven articles were identified, and a detailed review reduced this to eight trials. Four compared laparoscopic with open surgery, and four evaluated coloanal anastomotic techniques. The most commonly used HRQL instrument was the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30, and HRQL was usually a secondary outcome measure. In four (50%) trials, HRQL assessment was categorised as methodologically robust, although only two trials had sample size calculations based upon a HRQL endpoint. Six trials based the final treatment recommendation in the context of the HRQL outcomes.

Conclusion

In randomised surgical trials in CRC, HRQL assessment informs clinical decision making, and future trials require robust assessment of relevant patient-reported outcomes.
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Metadata
Title
Quality of life after surgery for colorectal cancer: clinical implications of results from randomised trials
Authors
Sameer Gujral
Kerry N. L. Avery
Jane M. Blazeby
Publication date
01-02-2008
Publisher
Springer-Verlag
Published in
Supportive Care in Cancer / Issue 2/2008
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-007-0356-2

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