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Published in: Supportive Care in Cancer 12/2007

01-12-2007 | Short Communication

High-dose corticosteroids for the management of dyspnea in patients with tumor obstruction of the upper airway

Authors: Ahmed Elsayem, Eduardo Bruera

Published in: Supportive Care in Cancer | Issue 12/2007

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Excerpt

Dyspnea is a frequent and devastating symptom in patients with advanced cancer [1, 2]. In patients with tumors of the upper mediastinum or neck, dyspnea is accompanied by objective physical findings such as stridor, pain in the area of neck or upper mediastinum, voice changes, and tumor infiltration of the head and neck tissues. This paper describes three cases of subjective and objective improvement of dyspnea because of upper airway involvement with the use of high-dose parenteral corticosteroids. …
Literature
1.
go back to reference Coweher K, Hanks GW (1990) Long term management of respiratory symptoms in advanced cancer. J Pain Sympt Manag 5:320–330CrossRef Coweher K, Hanks GW (1990) Long term management of respiratory symptoms in advanced cancer. J Pain Sympt Manag 5:320–330CrossRef
2.
go back to reference Bruera E, Ripamoni C (1998) Dyspnea in patients with advanced cancer. In: Berger A et al (ed) Principles and practices of supportive oncology, vol. 23. Lippincott–Raven, Philadelphia, pp 295–308 Bruera E, Ripamoni C (1998) Dyspnea in patients with advanced cancer. In: Berger A et al (ed) Principles and practices of supportive oncology, vol. 23. Lippincott–Raven, Philadelphia, pp 295–308
3.
go back to reference Filippelli M, Pacini F, Romagnoli I et al (2000) Airway obstruction and chronic exertional dyspnea in patients with persistent bronchial asthma. Respir Med 94(7):694–701PubMedCrossRef Filippelli M, Pacini F, Romagnoli I et al (2000) Airway obstruction and chronic exertional dyspnea in patients with persistent bronchial asthma. Respir Med 94(7):694–701PubMedCrossRef
4.
go back to reference Frew AJ, Hogate ST (1993) Clinical pharmacology of asthma. Implications for treatment. Drugs 46:847–862PubMed Frew AJ, Hogate ST (1993) Clinical pharmacology of asthma. Implications for treatment. Drugs 46:847–862PubMed
5.
go back to reference Weir Dc, Gove RI, Robertson AS et al (1991) Corticosteroids trials in non-asthmatic chronic airflow obstruction: a comparison of oral prednisolone and inhaled beclomethasone diproprionate. Thorax 45:112–117 Weir Dc, Gove RI, Robertson AS et al (1991) Corticosteroids trials in non-asthmatic chronic airflow obstruction: a comparison of oral prednisolone and inhaled beclomethasone diproprionate. Thorax 45:112–117
6.
go back to reference Schols Am, Soeters PB, Mostert R et al (1995) Physiologic effects of nutritional support and anabolic steroids in patients in patients with chronic obstructive pulmonary disease: a placebo controlled randomized trial. Am J Respir Crit Care Med 152:1268–1274PubMed Schols Am, Soeters PB, Mostert R et al (1995) Physiologic effects of nutritional support and anabolic steroids in patients in patients with chronic obstructive pulmonary disease: a placebo controlled randomized trial. Am J Respir Crit Care Med 152:1268–1274PubMed
7.
go back to reference Geimer NF, Donegan WL (1980) Role and mechanism of corticosteroid therapy in breast cancer. Rev Endocr-Relat Cancer 6:5–6 Geimer NF, Donegan WL (1980) Role and mechanism of corticosteroid therapy in breast cancer. Rev Endocr-Relat Cancer 6:5–6
8.
go back to reference Walsh TD, West TS (1988) Controlling symptoms in advanced cancer. Br Med J 296:477–481CrossRef Walsh TD, West TS (1988) Controlling symptoms in advanced cancer. Br Med J 296:477–481CrossRef
9.
go back to reference Kveton JF, Pillsbury HC (1982) Conservative treatment of infantile subglottic hemangioma with corticosteroids. Arch Otolaryngol 108(2):117–119PubMed Kveton JF, Pillsbury HC (1982) Conservative treatment of infantile subglottic hemangioma with corticosteroids. Arch Otolaryngol 108(2):117–119PubMed
10.
go back to reference Anonymous (1978) Treatment of complicated hemangiomas with adrenocorticosteroids when the integrity of important structures or life itself is threatened. J Dermatol Surg Oncol 4(11):854–858 Anonymous (1978) Treatment of complicated hemangiomas with adrenocorticosteroids when the integrity of important structures or life itself is threatened. J Dermatol Surg Oncol 4(11):854–858
11.
go back to reference Hawkins DB, Crockett DM, Kahlstrom EJ, MacLaughlin EF (1984) Corticosteroid management of airway hemangiomas: long-term follow-up. Laryngoscope 94(1):633–637PubMed Hawkins DB, Crockett DM, Kahlstrom EJ, MacLaughlin EF (1984) Corticosteroid management of airway hemangiomas: long-term follow-up. Laryngoscope 94(1):633–637PubMed
12.
go back to reference Mason BA, Dambra J, Grossman B et al (1982) Effective control of cisplatin-induced nausea using high-dose steroids and droperidol. Cancer 50:243–245 Mason BA, Dambra J, Grossman B et al (1982) Effective control of cisplatin-induced nausea using high-dose steroids and droperidol. Cancer 50:243–245
13.
go back to reference Schell H (1972) Adrenal corticosteroid therapy in far advanced cancer. Geriatric 27:131–141 Schell H (1972) Adrenal corticosteroid therapy in far advanced cancer. Geriatric 27:131–141
14.
go back to reference Bruera E, Roca E, Cedaro L et al (1985) Action of oral methylprednisolone in terminal cancer patients: a prospective randomized double-blind study. Cancer Treat Rep 69:751–754PubMed Bruera E, Roca E, Cedaro L et al (1985) Action of oral methylprednisolone in terminal cancer patients: a prospective randomized double-blind study. Cancer Treat Rep 69:751–754PubMed
15.
go back to reference Bruera E, MacEachern T, Ripamonti C et al (1993) Subcutaneous morphine for dyspnea in cancer patients. Ann Intern Med 119:906–907PubMed Bruera E, MacEachern T, Ripamonti C et al (1993) Subcutaneous morphine for dyspnea in cancer patients. Ann Intern Med 119:906–907PubMed
16.
go back to reference Bruera E, Macmillan K, Pither J et al (1990) The effects of morphine on the dyspnea of terminal cancer patients. J Pain Sympt Manag 5:341–344CrossRef Bruera E, Macmillan K, Pither J et al (1990) The effects of morphine on the dyspnea of terminal cancer patients. J Pain Sympt Manag 5:341–344CrossRef
17.
go back to reference Cohen MH, Johnston Anderson A, Krasnow SH et al (1991) Continuous intravenous infusion of morphine for severe dyspnea. South Med J 84:229–234PubMed Cohen MH, Johnston Anderson A, Krasnow SH et al (1991) Continuous intravenous infusion of morphine for severe dyspnea. South Med J 84:229–234PubMed
18.
go back to reference Del Fabbro E, Dalal S, Bruera E (2006) Symptom control in palliative care–Part III: dyspnea and delirium. J Palliat Med 9(2):422–436 ReviewPubMedCrossRef Del Fabbro E, Dalal S, Bruera E (2006) Symptom control in palliative care–Part III: dyspnea and delirium. J Palliat Med 9(2):422–436 ReviewPubMedCrossRef
19.
go back to reference Hilton G, Frei J (1991) High-dose methylprednisolone in the treatment of spinal cord injuries. Heart Lung 20(6):675–680PubMed Hilton G, Frei J (1991) High-dose methylprednisolone in the treatment of spinal cord injuries. Heart Lung 20(6):675–680PubMed
20.
go back to reference Muz J, Mathog RH, Nelson R, Jones LA Jr (2001) Aspiration in patients with head and neck cancer and tracheostomy. Am J Otolaryngol 10(4):282–286CrossRef Muz J, Mathog RH, Nelson R, Jones LA Jr (2001) Aspiration in patients with head and neck cancer and tracheostomy. Am J Otolaryngol 10(4):282–286CrossRef
21.
go back to reference Tanigawa N, Sawada S, Okuda Y et al (2000) Symptomatic improvement in dyspnea following tracheobronchial metallic stenting for malignant airway obstruction. Acta Radiol 41(5):694–701CrossRef Tanigawa N, Sawada S, Okuda Y et al (2000) Symptomatic improvement in dyspnea following tracheobronchial metallic stenting for malignant airway obstruction. Acta Radiol 41(5):694–701CrossRef
22.
go back to reference Kim H (1998) Stenting therapy for stenosing airway disease. Respirology 4:221–228 Kim H (1998) Stenting therapy for stenosing airway disease. Respirology 4:221–228
Metadata
Title
High-dose corticosteroids for the management of dyspnea in patients with tumor obstruction of the upper airway
Authors
Ahmed Elsayem
Eduardo Bruera
Publication date
01-12-2007
Publisher
Springer-Verlag
Published in
Supportive Care in Cancer / Issue 12/2007
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-007-0305-0

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