Skip to main content
Top
Published in: Supportive Care in Cancer 5/2007

01-05-2007 | Original Article

Impact of family structure on long-term survivors of osteosarcoma

Authors: A. Bressoud, O. Real del Sarte, S. Stiefel, P. Mordasini, L. Perey, J. Bauer, P. F. Leyvraz, S. Leyvraz

Published in: Supportive Care in Cancer | Issue 5/2007

Login to get access

Abstract

Goals of work

Long-term outcomes of osteosarcoma have dramatically improved with the use of modern combination therapies. Such aggressive treatments, however, entail chronic complications. In the present study, we assessed the functional, psychological, and familial status of long-term survivors of osteosarcoma treated at our institution.

Materials and methods

Fifteen long-term survivors of osteosarcoma were evaluated for functional and psychological sequelae. Functional assessment was based on a method described by Enneking et al. Psychological assessment was based on General Health Questionnaire 28, Inventory Scale for Traumatic Neurosis, and Family System Test.

Main results

Ten patients showed mild functional impairments; only five patients were handicapped more seriously. Depressive symptoms were diagnosed in four patients. A total of six patients revealed unbalanced family structures, including three of the four patients with depressive symptoms, all four patients with symptoms of posttraumatic stress disorder, and five of seven patients who showed poor emotional acceptance.

Conclusions

Osteosarcoma survivors will generally recover good functional performance. Only a minority of them remain seriously impaired. One third of the patients present depressive symptoms and posttraumatic stress disorder. Poor coping is closely associated with unbalanced family structures. Therefore, the psychological and familial situation of patients with newly diagnosed osteosarcoma should be carefully assessed.
Literature
1.
go back to reference Aksnes LH, Hall KS, Folleraas G, Stenwig AE, Bjerkehagen B, Taksdal I, Winderen M, Bruland OS, Saeter G (2006) Management of high-grade bone sarcomas over two decades: the Norwegian Radium Hospital experience. Acta Oncol 45(1):38–46PubMedCrossRef Aksnes LH, Hall KS, Folleraas G, Stenwig AE, Bjerkehagen B, Taksdal I, Winderen M, Bruland OS, Saeter G (2006) Management of high-grade bone sarcomas over two decades: the Norwegian Radium Hospital experience. Acta Oncol 45(1):38–46PubMedCrossRef
2.
go back to reference Babin SR, Simon P, Babin-Boilletot A, Bellocq JP, Marcellin L, Dosch JC (1996) Complications and results in high-grade osteosarcoma of the lower limb. A study of 20 cases. Rev Chir Orthop 82:14–21PubMed Babin SR, Simon P, Babin-Boilletot A, Bellocq JP, Marcellin L, Dosch JC (1996) Complications and results in high-grade osteosarcoma of the lower limb. A study of 20 cases. Rev Chir Orthop 82:14–21PubMed
3.
go back to reference Bielack SS, Kempf-Bielack B, Delling G, Exner U, Flege S, Helmke K, Katz R, Werner M, Winkelmann W, Zoubek A, Jurgens H (2002) Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols. J Clin Oncol 20:776–790PubMedCrossRef Bielack SS, Kempf-Bielack B, Delling G, Exner U, Flege S, Helmke K, Katz R, Werner M, Winkelmann W, Zoubek A, Jurgens H (2002) Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols. J Clin Oncol 20:776–790PubMedCrossRef
4.
go back to reference Bolognini M, Bettschart W, Zehnder-Gubler M, Rossier L (1989) The validity of the French version of the GHQ-28 and PSYDIS in a community sample of 20 year olds in Switzerland. Eur Arch Psychiatr Neurol Sci 238(3):161–168CrossRef Bolognini M, Bettschart W, Zehnder-Gubler M, Rossier L (1989) The validity of the French version of the GHQ-28 and PSYDIS in a community sample of 20 year olds in Switzerland. Eur Arch Psychiatr Neurol Sci 238(3):161–168CrossRef
5.
go back to reference Boman K, Bodegard G (1995) Psychological long-term coping with experience of treatment in childhood cancer survivors. Acta Paediatr 84:1395–1402PubMed Boman K, Bodegard G (1995) Psychological long-term coping with experience of treatment in childhood cancer survivors. Acta Paediatr 84:1395–1402PubMed
6.
go back to reference Bordmann AP (1987) The general health questionnaire and the detection of emotional disorder by general practitioners, a replicated study. Br J Psychiatry 151:373–381CrossRef Bordmann AP (1987) The general health questionnaire and the detection of emotional disorder by general practitioners, a replicated study. Br J Psychiatry 151:373–381CrossRef
7.
go back to reference Cameron KT (1993) Psychological effects of amputation in osteosarcoma. In: Osteosarcoma in adolescents and young adults. Kluwer, Boston, pp 39–44 Cameron KT (1993) Psychological effects of amputation in osteosarcoma. In: Osteosarcoma in adolescents and young adults. Kluwer, Boston, pp 39–44
8.
go back to reference Enneking WF, DunHam W, Gebhardt MC, Malawar M, Pritchard DJ (1993) A system for functional evaluation of reconstructive procedures after surgical treatment of tumors of the musculoskeletal system. Clin Orthop Relat Res 286:241–246PubMed Enneking WF, DunHam W, Gebhardt MC, Malawar M, Pritchard DJ (1993) A system for functional evaluation of reconstructive procedures after surgical treatment of tumors of the musculoskeletal system. Clin Orthop Relat Res 286:241–246PubMed
9.
go back to reference Fritz GK, Williams JR, Amylon M (1988) Psychosocial sequelae in pediatric cancer survivors. Am J Orthopsychiatr 58(4):552–561CrossRef Fritz GK, Williams JR, Amylon M (1988) Psychosocial sequelae in pediatric cancer survivors. Am J Orthopsychiatr 58(4):552–561CrossRef
10.
go back to reference Gehring T. Family System Test (FAST), Authorized English translation by Anita Arone Reitzle, Zurich, Switzerland. First publication in 1993 By Beltz Verlag, Germany, under the title of Familiensystemtest (FAST). Copyright Beltz Gessellschaft Gehring T. Family System Test (FAST), Authorized English translation by Anita Arone Reitzle, Zurich, Switzerland. First publication in 1993 By Beltz Verlag, Germany, under the title of Familiensystemtest (FAST). Copyright Beltz Gessellschaft
11.
go back to reference Greenberg DB, Goorin A, Gebhardt MC, Gupta L, Stier N, Harmon D, Mankin H (1994) Quality of life in osteosarcoma survivors. Oncology 8(11):19–25PubMed Greenberg DB, Goorin A, Gebhardt MC, Gupta L, Stier N, Harmon D, Mankin H (1994) Quality of life in osteosarcoma survivors. Oncology 8(11):19–25PubMed
12.
go back to reference Hobbie WL, Stuber M, Meeske K, Wissler K, Rourke M, Ruccione K, Hinkle A, Kazak AE (2000) Symptoms of posttraumatic stress in young adult survivors of childhood cancer. J Clin Oncol 18:4060–4066PubMed Hobbie WL, Stuber M, Meeske K, Wissler K, Rourke M, Ruccione K, Hinkle A, Kazak AE (2000) Symptoms of posttraumatic stress in young adult survivors of childhood cancer. J Clin Oncol 18:4060–4066PubMed
13.
go back to reference Hudson MM, Mertens AC, Yasui Y, Hobbie W, Chen H, Gurney JG, Yeazel M, Recklitis CJ, Marina N, Robinson L, Oeffinger K (2003) Health status of adult long-term survivors of childhood cancer. JAMA 290:1583–1592PubMedCrossRef Hudson MM, Mertens AC, Yasui Y, Hobbie W, Chen H, Gurney JG, Yeazel M, Recklitis CJ, Marina N, Robinson L, Oeffinger K (2003) Health status of adult long-term survivors of childhood cancer. JAMA 290:1583–1592PubMedCrossRef
14.
go back to reference Kazak AE, Meadows AT (1989) Families of young adolescents who have survived cancer: socio-emotional adjustment, adaptability and social support. J Pediatr Psychol 14:175–191PubMedCrossRef Kazak AE, Meadows AT (1989) Families of young adolescents who have survived cancer: socio-emotional adjustment, adaptability and social support. J Pediatr Psychol 14:175–191PubMedCrossRef
15.
go back to reference Koopmann HM, Koetsier JA, Taminiau AH, Hijnen KE, Bresters D, Egeler RM (2005) Health-related quality of life and coping strategies of children after treatment of a malignant bone tumor: a 5-year follow-up study. Pediatr Blood Cancer 45:694–699CrossRef Koopmann HM, Koetsier JA, Taminiau AH, Hijnen KE, Bresters D, Egeler RM (2005) Health-related quality of life and coping strategies of children after treatment of a malignant bone tumor: a 5-year follow-up study. Pediatr Blood Cancer 45:694–699CrossRef
16.
go back to reference Maunsell E, Pogany L, Barrera M, Shaw AK, Speechley KN (2006) Quality of life among long-term adolescent and adult survivors of childhood cancer. J Clin Oncol 24:2527–2535PubMedCrossRef Maunsell E, Pogany L, Barrera M, Shaw AK, Speechley KN (2006) Quality of life among long-term adolescent and adult survivors of childhood cancer. J Clin Oncol 24:2527–2535PubMedCrossRef
17.
go back to reference Nagarajan R, Neglia JP, Clohisy DR, Yasui Y, Greenberg M, Hudson M, Zevon M, Tersak JM, Albin A, Robinson LL (2003) Education, employment, insurance, and marital status among 694 survivors of pediatric lower extremity bone tumors. Cancer 97:2554–2564PubMedCrossRef Nagarajan R, Neglia JP, Clohisy DR, Yasui Y, Greenberg M, Hudson M, Zevon M, Tersak JM, Albin A, Robinson LL (2003) Education, employment, insurance, and marital status among 694 survivors of pediatric lower extremity bone tumors. Cancer 97:2554–2564PubMedCrossRef
18.
go back to reference Nicholson HC, Mulvihill JJ (1993) Late effects of therapy in survivors of childhood and adolescent osteosarcoma. Cancer Treat Res 62:45–48PubMed Nicholson HC, Mulvihill JJ (1993) Late effects of therapy in survivors of childhood and adolescent osteosarcoma. Cancer Treat Res 62:45–48PubMed
19.
go back to reference Pardasaney PK, Sullivan PE, Portney LG, Mankin HJ (2006) Advantage of limb salvage over amputation for proximal lower extremity tumors. Clin Orthop Relat Res 444:201–208PubMedCrossRef Pardasaney PK, Sullivan PE, Portney LG, Mankin HJ (2006) Advantage of limb salvage over amputation for proximal lower extremity tumors. Clin Orthop Relat Res 444:201–208PubMedCrossRef
20.
go back to reference Perey L, Guillou L, Jallut D, Beck D, Livio JJ, Leyvraz S (1995) Traitement combiné des ostéosarcomes: expérience lausannoise. Méd et Hyg 53:2318–2324 Perey L, Guillou L, Jallut D, Beck D, Livio JJ, Leyvraz S (1995) Traitement combiné des ostéosarcomes: expérience lausannoise. Méd et Hyg 53:2318–2324
21.
go back to reference Real del Sarte O (1996) Psychosomatique et chronicité débat autour d’une recherche. Thér Fam 17:225–239 Real del Sarte O (1996) Psychosomatique et chronicité débat autour d’une recherche. Thér Fam 17:225–239
22.
go back to reference Real del Sarte O, Stiefel F, Leyvraz S, Bauer J, Gehring TM, Guex P (1998) The Family System Test, a pilot study in families with a young adult member with cancer. Support Care Cancer 6:416–420CrossRef Real del Sarte O, Stiefel F, Leyvraz S, Bauer J, Gehring TM, Guex P (1998) The Family System Test, a pilot study in families with a young adult member with cancer. Support Care Cancer 6:416–420CrossRef
23.
go back to reference Rolland JS (1987) Chronic illness and the life cycle. Fam Proc 26:203–221CrossRef Rolland JS (1987) Chronic illness and the life cycle. Fam Proc 26:203–221CrossRef
24.
go back to reference Rougraff BT, Simon MA, Kneisl JS, Greenberg DB, Mankin HJ (1994) Limb salvage compared with amputation for osteosarcoma of the distal end of the femur. J Bone Jt Surg 76-A:649–656 Rougraff BT, Simon MA, Kneisl JS, Greenberg DB, Mankin HJ (1994) Limb salvage compared with amputation for osteosarcoma of the distal end of the femur. J Bone Jt Surg 76-A:649–656
25.
go back to reference Schwartz CL (2003) Health status of childhood cancer survivors. Cure is more than the eradication of cancer. JAMA 290:1641–1643PubMedCrossRef Schwartz CL (2003) Health status of childhood cancer survivors. Cure is more than the eradication of cancer. JAMA 290:1641–1643PubMedCrossRef
26.
go back to reference Schwartz L, Drotar D (2006) Posttraumatic stress and related impairment in survivors of childhood cancer in early adulthood compared to healthy peers. J Pediatr Psychol 31:356–366PubMedCrossRef Schwartz L, Drotar D (2006) Posttraumatic stress and related impairment in survivors of childhood cancer in early adulthood compared to healthy peers. J Pediatr Psychol 31:356–366PubMedCrossRef
27.
go back to reference Steinitz A, Crocq L (1992) L’inventaire-échelle de névrose traumatique. Psychol Méd 24:437–445 Steinitz A, Crocq L (1992) L’inventaire-échelle de névrose traumatique. Psychol Méd 24:437–445
28.
go back to reference Taieb O, Moro MR, Baubet T, Revah-Levy A, Flament MF (2003) Posttraumatic stress symptoms after childhood cancer. Eur Child Adolesc Psychiatry 12:255–264PubMedCrossRef Taieb O, Moro MR, Baubet T, Revah-Levy A, Flament MF (2003) Posttraumatic stress symptoms after childhood cancer. Eur Child Adolesc Psychiatry 12:255–264PubMedCrossRef
29.
go back to reference Wasserman AL, Thompson EI, Williams JA, Fairclough DL (1987) The psychological status of survivors of childhood/adolescent Hodgkin’s disease. Am J Dis Child 141(6):626–631PubMed Wasserman AL, Thompson EI, Williams JA, Fairclough DL (1987) The psychological status of survivors of childhood/adolescent Hodgkin’s disease. Am J Dis Child 141(6):626–631PubMed
30.
go back to reference Weddington WW Jr, Segraves KB, Simon MA (1985) Psychological outcome of extremity sarcoma survivors undergoing amputation or limb salvage. J Clin Oncol 3:1393–1399PubMed Weddington WW Jr, Segraves KB, Simon MA (1985) Psychological outcome of extremity sarcoma survivors undergoing amputation or limb salvage. J Clin Oncol 3:1393–1399PubMed
31.
go back to reference Wood B, Watkins JB, Boyle JT (1989) The psychosomatic family model, an empirical and theoretical analysis. Fam Proc 28:399–417CrossRef Wood B, Watkins JB, Boyle JT (1989) The psychosomatic family model, an empirical and theoretical analysis. Fam Proc 28:399–417CrossRef
32.
go back to reference Zebrack BJ, Zeltzer LK, Whitton J, Mertens AC, Odom L, Berkow R, Robinson LL (2002) Psychological outcomes in long-term survivors of childhood leukaemia, Hodgkin’s disease, and non-Hodgkin’s lymphoma. Pediatrics 110:42–52PubMedCrossRef Zebrack BJ, Zeltzer LK, Whitton J, Mertens AC, Odom L, Berkow R, Robinson LL (2002) Psychological outcomes in long-term survivors of childhood leukaemia, Hodgkin’s disease, and non-Hodgkin’s lymphoma. Pediatrics 110:42–52PubMedCrossRef
33.
go back to reference Zebrack BJ, Zevon MA, Turk N, Nagarajan R, Whitton J, Robinson LL, Zeltzer LK (2006) Psychological distress in long-term survivors of solid tumors diagnosed in childhood: a report from the childhood cancer survivor study. Pediatr Blood Cancer, Jun 5; [Epub ahead of print] Zebrack BJ, Zevon MA, Turk N, Nagarajan R, Whitton J, Robinson LL, Zeltzer LK (2006) Psychological distress in long-term survivors of solid tumors diagnosed in childhood: a report from the childhood cancer survivor study. Pediatr Blood Cancer, Jun 5; [Epub ahead of print]
Metadata
Title
Impact of family structure on long-term survivors of osteosarcoma
Authors
A. Bressoud
O. Real del Sarte
S. Stiefel
P. Mordasini
L. Perey
J. Bauer
P. F. Leyvraz
S. Leyvraz
Publication date
01-05-2007
Publisher
Springer-Verlag
Published in
Supportive Care in Cancer / Issue 5/2007
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-006-0196-5

Other articles of this Issue 5/2007

Supportive Care in Cancer 5/2007 Go to the issue
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine