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Supportive Care in Cancer

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01-03-2006 | Original Article

Quality of life of testicular cancer survivors and the relationship with sociodemographics, cancer-related variables, and life events

Authors: J. Fleer, H. J. Hoekstra, D. T. Sleijfer, M. A. Tuinman, E. C. Klip, J. E. H. M. Hoekstra-Weebers

Published in: Supportive Care in Cancer | Issue 3/2006

Abstract

Goals of work

The aim of this study was to (1) assess the quality of life (QoL) of testicular cancer survivors (TCSs) by comparing them to a reference group; (2) investigate the relationship between the QoL of TCSs and sociodemographics, cancer-related variables, and life events; and (3) identify TCSs at risk for an impaired QoL.

Patients and methods

Of the TCSs approached, 50% (n=354) participated and completed a generic QoL questionnaire (RAND-36) once. Time since completion of treatment varied from 3 months to 24 years.

Main results

(1) TCSs had significantly higher mean scores on the subscales physical functioning (p=0.02) and pain (p=0.001), but lower mean scores on mental health (p=0.04) and vitality (p<0.001) than a reference group of men. The effect sizes of these differences were small to insignificant. (2) Employment status and chronic disease were the main correlates of the QoL of TCSs. Age, negative life events, type of treatment, and the experience of a second cancer event were moderately associated with some subscales as well. (3) The joint burden of unemployment and a chronic disease was the strongest predictor for an impaired functioning.

Conclusions

On a group level, TCSs experience a good QoL, but a small group appeared to be at risk for an impaired functioning, namely, those who were unemployed and had a chronic disease. The variance explained by the variables studied was low, indicating that more important predictors remain to be identified.

Arai Y, Kawakita M, Hida S, Terachi T, Okada Y, Yoshida O (1996) Psychosocial aspects in long-term survivors of testicular cancer. J Urol 155:574–578CrossRefPubMed

Bardwell WA, Major JM, Rock CL, Newman VA, Thomson CA, Chilton JA, Dimsdale JE, Pierce JP (2004) Health-related quality of life in women previously treated for early-stage breast cancer. Psycho-Oncol

Bjordal K, Mastekaasa A, Kaasa S (1995) Self-reported satisfaction with life and physical health in long-term cancer survivors and a matched control group. Eur J Cancer B Oral Oncol 31B:340–345CrossRefPubMed

Bosl GJ, Motzer RJ (1997) Testicular germ-cell cancer. N Engl J Med 337:242–253CrossRefPubMed

Brazier JE, Harper R, Jones NMB, O’Cathain A, Thomas KJ, Usherwood T, Westlake L (1992) Validating the SF-36 health survey questionnaire: new outcome measure for primary care. BMJ 305:160–164PubMed

Caffo O, Amichetti M, Tomio L, Galligioni E (2001) Quality of life after radiotherapy for early-stage testicular seminoma. Radiother Oncol 59:13–20CrossRefPubMed

Cohen J (1988) Statistical power analysis for the behavioral sciences. Erlbaum, Hillsdale, NJ

Dearnaley D, Huddart R, Horwich A (2001) Regular review: managing testicular cancer. BMJ 322:1583–1588CrossRefPubMed

Efficace F, Bottomley A, Osoba D, Gotay C, Flechtner H, D’haese S, Zurlo A (2003) Beyond the development of health-related quality-of-life (HRQOL) measures: a checklist for evaluating HRQOL outcomes in cancer clinical trials—Does HRQOL evaluation in prostate cancer research inform clinical decision making? J Clin Oncol 21:3502–3511CrossRefPubMed

10.

Festinger L (1957) A theory of cognitive dissonance. New York

11.

Fleer J, Hoekstra HJ, Sleijfer DT, Hoekstra-Weebers JEHM (2004) Quality of life of survivors of testicular germ cell cancer: a review of the literature. Support Care Cancer 12:476–486CrossRefPubMed

12.

Forehand R, Biggar H, Kotchick BA (1998) Cumulative risk across family stressors: short- and long-term effects for adolescents. J Abnorm Child Psychol 26:119–128CrossRefPubMed

13.

Fossa SD, Dahl AA, Loge JH (2003) Fatigue, anxiety, and depression in long-term survivors of testicular cancer. J Clin Oncol 21:1249–1254CrossRefPubMed

14.

Ganz PA, Rowland JH, Desmond K, Meyerowitz BE, Wyatt GE (1998) Life after breast cancer: understanding women’s health-related quality of life and sexual functioning. J Clin Oncol 16:501–514PubMed

15.

Gotay CC, Muraoka MY (1998) Quality of life in long-term survivors of adult-onset cancers. J Natl Cancer Inst 90:656–667CrossRefPubMed

16.

Greaves-Otte JG, Greaves J, Kruyt PM, van Leeuwen O, van der Wouden JC, van der DE (1991) Problems at social re-integration of long-term cancer survivors. Eur J Cancer 27:178–181PubMed

17.

Hays RD, Donald Sherbourne C, Mazel RM (1993) The RAND 36-item health survey 1.0. Health Econ 2:217–227PubMed

18.

Joly F, Heron JF, Kalusinski L, Bottet P, Brune D, Allouache N, Mace-Lesec’h J, Couette JE, Peny J, Henry-Amar M (2002) Quality of life in long-term survivors of testicular cancer: a population-based case-control study. J Clin Oncol 20:73–80CrossRefPubMed

19.

Matsuda T, Marche H, Grosclaude P, Clement S (2004) Participation behavior of bladder cancer survivors in a medical follow-up survey on quality of life in France. Eur J Epidemiol 19:313–321CrossRefPubMed

20.

Meinardi MT, Gietema JA, van der Graaf WT, van Veldhuisen DJ, Runne MA, Sluiter WJ, de Vries EG, Willemse PB, Mulder NH, van den Berg MP, Koops HS, Sleijfer DT (2000) Cardiovascular morbidity in long-term survivors of metastatic testicular cancer. J Clin Oncol 18:1725–1732PubMed

21.

Michelson H, Bolund C, Brandberg Y (2000) Multiple chronic health problems are negatively associated with health related quality of life (HRQoL) irrespective of age. Qual Life Res 9:1093–1104CrossRefPubMed

22.

Michelson H, Bolund C, Nilsson B, Brandberg Y (2000) Health-related quality of life measured by the EORTC QLQ-C30: reference values from a large sample of the Swedish population. Acta Oncol 39:477–484CrossRefPubMed

23.

Parker PA, Baile WF, Moor CC, Cohen L (2003) Psychosocial and demographic predictors of quality of life in a large sample of cancer patients. Psycho-Oncol 12:183–193CrossRef

24.

Rudberg L, Nilsson S, Wikblad K (2000) Health-related quality of life in survivors of testicular cancer 3 to 13 years after treatment. J Psychosoc Oncol 18:19–31CrossRef

25.

Schlenk EA, Erlen JA, Dunbar-Jacob J, McDowell J, Engberg S, Sereika SM, Rohay JM, Bernier MJ (1998) Health-related quality of life in chronic disorders: a comparison across studies using the MOS SF-36. Qual Life Res 7:57–65CrossRefPubMed

26.

Schnoll RA, Harlow LL (2001) Using disease-related and demographic variables to form cancer-distress risk groups. J Behav Med 24:57–74CrossRefPubMed

27.

Sprangers MA, Schwartz CE (1999) Integrating response shift into health-related quality of life research: a theoretical model. Soc Sci Med 48:1507–1515CrossRefPubMed

28.

Travis LB, Curtis RE, Storm H, Hall P, Holowaty E, Van Leeuwen FE, Kohler BA, Pukkala E, Lynch CF, Andersson M, Bergfeldt K, Clarke EA, Wiklund T, Stoter G, Gospodarowicz M, Sturgeon J, Fraumeni JF Jr, Boice JD Jr (1997) Risk of second malignant neoplasms among long-term survivors of testicular cancer. J Natl Cancer Inst 89:1429–1439CrossRefPubMed

29.

Van de Willige G, Schreurs P, Tellegen B, Zwart F (1985) Het meten van ‘life events’: de Vragenlijst Recent Meegemaakte Gebeurtenissen (VRMG). Nederlands Tijdschrift voor de Psychologie 40:1–19

30.

Van der Zee KI, Sanderman, R (1993) The measurement of generic health with the RAND-36. Northern Centre for Healthcare Research. http://www.coo.med.rug.nl.nch. Cited 14 Apr 2005

31.

Vidrine DJ, Gritz ER (2003) Psychosocial outcomes after testicular cancer treatment. In: Steele Jr GD, Phillips TL, Chabner BA, Gansler TS (eds) Germ cell tumors—American Cancer Society atlas of clinical oncology. BC Decker Inc., Hamilton, London, pp 295–305

32.

Wingard JR, Curbow B, Baker F, Piantadosi S (1991) Health, functional status, and employment of adult survivors of bone-marrow transplantation. Ann Intern Med 114:113–118PubMed

33.

Zebrack BJ, Chesler M (2001) Health-related worries, self-image, and life outlooks of long-term survivors of childhood cancer. Health Soc. Work 26:245–256PubMed

Title: Quality of life of testicular cancer survivors and the relationship with sociodemographics, cancer-related variables, and life events
Authors: J. Fleer
H. J. Hoekstra
D. T. Sleijfer
M. A. Tuinman
E. C. Klip
J. E. H. M. Hoekstra-Weebers
Publication date: 01-03-2006
Publisher: Springer-Verlag
Published in: Supportive Care in Cancer / Issue 3/2006
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-005-0879-3

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Abstract

Goals of work

Patients and methods

Main results

Conclusions

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