Skip to main content
Top
Published in: Supportive Care in Cancer 7/2004

01-07-2004 | Short Communication

Catastrophic heparin-induced thrombocytopenia/thrombosis syndrome related to the use of a Port-A-Cath in a breast cancer patient receiving chemotherapy

Authors: Ming-Shen Dai, An-Tie Hsieh, Tsu-Yi Chao

Published in: Supportive Care in Cancer | Issue 7/2004

Login to get access

Abstract

Heparin-induced thrombocytopenia and thrombosis (HIT/T) syndrome is usually triggered by an immune response after repeated administration of heparin. The syndrome is strongly associated with limb deep vein thrombosis and is potentially life-threatening if unrecognized. We describe the case of a patient with compartment syndrome of the left forearm complicated by HIT/T that developed after Port-A-Cath implantation through the left subclavian vein. Prompt recognition of HIT/T, immediate withdrawal of heparin, and timely institution of thrombolytic therapy successfully prevented limb loss.
Literature
1.
go back to reference Warkentin TE (2003) Heparin-induced thrombocytopenia: pathogenesis and management. Br J Haematol 121:535–555CrossRefPubMed Warkentin TE (2003) Heparin-induced thrombocytopenia: pathogenesis and management. Br J Haematol 121:535–555CrossRefPubMed
2.
go back to reference Gruel Y, Lang M, Darnige L, Pacouret G, Dreyfus X, Leroy J, Charbonnier B (1990) Fatal effect of re-exposure to heparin after previous heparin-associated thrombocytopenia and thrombosis. Lancet 336:1077–1078CrossRef Gruel Y, Lang M, Darnige L, Pacouret G, Dreyfus X, Leroy J, Charbonnier B (1990) Fatal effect of re-exposure to heparin after previous heparin-associated thrombocytopenia and thrombosis. Lancet 336:1077–1078CrossRef
3.
go back to reference Aird WC, Mark EJ (2002) A 53-year-old man with a myocardial infarct and thromboses after coronary-artery bypass grafting. N Engl J Med 346:1562–1570CrossRefPubMed Aird WC, Mark EJ (2002) A 53-year-old man with a myocardial infarct and thromboses after coronary-artery bypass grafting. N Engl J Med 346:1562–1570CrossRefPubMed
4.
go back to reference Hong AP, Cook DJ, Sigoulin CS, Warkentin TE (2003) Central venous catheters and upper-extremity deep-vein thrombosis complicating immune heparin-induced thrombocytopenia. Blood 101:3049–3051CrossRefPubMed Hong AP, Cook DJ, Sigoulin CS, Warkentin TE (2003) Central venous catheters and upper-extremity deep-vein thrombosis complicating immune heparin-induced thrombocytopenia. Blood 101:3049–3051CrossRefPubMed
5.
go back to reference Baglin TP (2001) Heparin induced thrombocytopenia thrombosis syndrome: diagnosis and treatment. J Clin Pathol 54:272–274CrossRefPubMed Baglin TP (2001) Heparin induced thrombocytopenia thrombosis syndrome: diagnosis and treatment. J Clin Pathol 54:272–274CrossRefPubMed
6.
go back to reference Lam F, Hussain S, Li P (2001) Limb loss following the use of heparin: a lesson to be remembered. J Bone Joint Surg 83:588–589CrossRef Lam F, Hussain S, Li P (2001) Limb loss following the use of heparin: a lesson to be remembered. J Bone Joint Surg 83:588–589CrossRef
7.
go back to reference Warkentin TE, Kelton JG (2001) Temporal aspects of heparin-induced thrombocytopenia. N Engl J Med 344:1286–1292 Warkentin TE, Kelton JG (2001) Temporal aspects of heparin-induced thrombocytopenia. N Engl J Med 344:1286–1292
8.
9.
go back to reference Warkentin TE (1998) Limitation of conventional treatment options for heparin-induced thrombocytopenia. Semin Hematol 35 [4 Suppl 5]:17–25 Warkentin TE (1998) Limitation of conventional treatment options for heparin-induced thrombocytopenia. Semin Hematol 35 [4 Suppl 5]:17–25
10.
go back to reference Mehta DP, Yoder EL, Appel J, Bergsman KL (1991) Heparin-induced thrombocytopenia and thrombosis: reversal with streptokinase: a case report and review of literature. Am J Hematol 36:275–279PubMed Mehta DP, Yoder EL, Appel J, Bergsman KL (1991) Heparin-induced thrombocytopenia and thrombosis: reversal with streptokinase: a case report and review of literature. Am J Hematol 36:275–279PubMed
11.
go back to reference Murphy KD, McCrohan G, DeMarta DA, Shirodkar NB, Kwon OJ, Chopra PS (1996) The heparin-induced thrombocytopenia and thrombosis syndrome: treatment with intraarterial urokinase and systemic platelet aggregation inhibitors. Cardiovasc Intervent Radiol 19:123–127CrossRefPubMed Murphy KD, McCrohan G, DeMarta DA, Shirodkar NB, Kwon OJ, Chopra PS (1996) The heparin-induced thrombocytopenia and thrombosis syndrome: treatment with intraarterial urokinase and systemic platelet aggregation inhibitors. Cardiovasc Intervent Radiol 19:123–127CrossRefPubMed
12.
go back to reference Poullin P, Pietri PA, Lefevre P (1998) Heparin-induced thrombocytopenia with thrombosis: successful treatment with plasma exchange. Br J Haematol 102:630–631CrossRefPubMed Poullin P, Pietri PA, Lefevre P (1998) Heparin-induced thrombocytopenia with thrombosis: successful treatment with plasma exchange. Br J Haematol 102:630–631CrossRefPubMed
Metadata
Title
Catastrophic heparin-induced thrombocytopenia/thrombosis syndrome related to the use of a Port-A-Cath in a breast cancer patient receiving chemotherapy
Authors
Ming-Shen Dai
An-Tie Hsieh
Tsu-Yi Chao
Publication date
01-07-2004
Publisher
Springer-Verlag
Published in
Supportive Care in Cancer / Issue 7/2004
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-004-0631-4

Other articles of this Issue 7/2004

Supportive Care in Cancer 7/2004 Go to the issue

Society News

July 2004

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine