Skip to main content
Top
Published in: Pediatric Nephrology 7/2019

01-07-2019 | Peritoneal Dialysis | Editorial Commentary

Iodine excess in children with kidney disease: are we missing hypothyroidism?

Author: Lesley Rees

Published in: Pediatric Nephrology | Issue 7/2019

Login to get access

Excerpt

Cohen et al. [1] report on iodine toxicity and hypothyroidism following micturating cystourethrography (MCUG) in two infants with CKD stage 5. The authors postulate that iodine in the contrast medium instilled into the bladder is absorbed and causes hypothyroidism. This is a very important observation, particularly in infants because of the role of thyroid hormones in cognitive development. …
Literature
1.
go back to reference Cohen L, Baudouin V, Ali L, Tanase A, Frerot A (2019) Voiding cystography, an unusual route of induced hypothyroidism by iodine overdose in two newborns with chronic kidney disease. Pediatr Nephrol Cohen L, Baudouin V, Ali L, Tanase A, Frerot A (2019) Voiding cystography, an unusual route of induced hypothyroidism by iodine overdose in two newborns with chronic kidney disease. Pediatr Nephrol
3.
go back to reference Thaker VV, Galler MF, Marshall AC, Almodovar MC, Hsu HW, Addis CJ, Feldman HA, Brown RS, Levine BS (2017) Hypothyroidism in infants with congenital heart disease exposed to excess iodine. J Endocr Soc 11:1067–1078CrossRef Thaker VV, Galler MF, Marshall AC, Almodovar MC, Hsu HW, Addis CJ, Feldman HA, Brown RS, Levine BS (2017) Hypothyroidism in infants with congenital heart disease exposed to excess iodine. J Endocr Soc 11:1067–1078CrossRef
4.
5.
go back to reference Lee SY, Rhee CM, Leung AM, Braverman LE, Brent GA, Pearce EN (2015) A review: radiographic iodinated contrast media-induced thyroid dysfunction. J Clin Endocrinol Metab 100:376–383CrossRefPubMed Lee SY, Rhee CM, Leung AM, Braverman LE, Brent GA, Pearce EN (2015) A review: radiographic iodinated contrast media-induced thyroid dysfunction. J Clin Endocrinol Metab 100:376–383CrossRefPubMed
6.
go back to reference Lee SY, Chang DLF, Xuemei He X, Pearce EN, Braverman LE, Leung AM (2015) Urinary iodine excretion and serum thyroid function in adults after iodinated contrast administration. Thyroid 25:471–477CrossRefPubMedPubMedCentral Lee SY, Chang DLF, Xuemei He X, Pearce EN, Braverman LE, Leung AM (2015) Urinary iodine excretion and serum thyroid function in adults after iodinated contrast administration. Thyroid 25:471–477CrossRefPubMedPubMedCentral
8.
go back to reference Department of Health. Dietary reference values for food, energy and nutrients in the United Kingdom no. 41. London: HMSO; 1991 Department of Health. Dietary reference values for food, energy and nutrients in the United Kingdom no. 41. London: HMSO; 1991
9.
go back to reference Jahreis G, Hausmann W, Kiessling G, Franke K, Leiterer M (2001) Bioavailability of iodine from normal diets rich in dairy products--results of balance studies in women. Exp Clin Endocrinol Diabetes 109:163–167CrossRef Jahreis G, Hausmann W, Kiessling G, Franke K, Leiterer M (2001) Bioavailability of iodine from normal diets rich in dairy products--results of balance studies in women. Exp Clin Endocrinol Diabetes 109:163–167CrossRef
10.
go back to reference Sanai T, Okamura K, Rikitake S, Fukuda M, Onozawa K, Sanematsu M, Takashima T, Miyazono M, Ikeda Y (2017) The high prevalence of reversible subclinical hypothyroidism with elevated serum thyroglobulin levels in chronic kidney disease patients. Clin Nephrol 87:237–244CrossRefPubMed Sanai T, Okamura K, Rikitake S, Fukuda M, Onozawa K, Sanematsu M, Takashima T, Miyazono M, Ikeda Y (2017) The high prevalence of reversible subclinical hypothyroidism with elevated serum thyroglobulin levels in chronic kidney disease patients. Clin Nephrol 87:237–244CrossRefPubMed
11.
go back to reference Belloni E, Tentoni S, Puci MV, Avogliero F, Della Latta D, Storti S, Alberti B, Bottoni A, Bortolotto C, Fiorina I, Montomoli C, Chiappino D (2018) Effect of iodinated contrast medium on thyroid function: a study in children undergoing cardiac computed tomography. Pediatr Radiol 48:1417–1422CrossRefPubMed Belloni E, Tentoni S, Puci MV, Avogliero F, Della Latta D, Storti S, Alberti B, Bottoni A, Bortolotto C, Fiorina I, Montomoli C, Chiappino D (2018) Effect of iodinated contrast medium on thyroid function: a study in children undergoing cardiac computed tomography. Pediatr Radiol 48:1417–1422CrossRefPubMed
12.
go back to reference Thaker VV, Leung AM, Braverman LE, Brown RS, Levine B (2014) Iodine-induced hypothyroidism in full-term infants with congenital heart disease: more common than currently appreciated? J Clin Endocrinol Metab 99:3521–3526CrossRefPubMedPubMedCentral Thaker VV, Leung AM, Braverman LE, Brown RS, Levine B (2014) Iodine-induced hypothyroidism in full-term infants with congenital heart disease: more common than currently appreciated? J Clin Endocrinol Metab 99:3521–3526CrossRefPubMedPubMedCentral
13.
go back to reference Barr ML, Chiu HK, Li N, Yeh MW, Rhee CM, Casillas J, Iskander PJ, Leung AM (2016) Thyroid dysfunction in children exposed to iodinated contrast media. J Clin Endocrinol Metab 101:2366–2370CrossRefPubMedPubMedCentral Barr ML, Chiu HK, Li N, Yeh MW, Rhee CM, Casillas J, Iskander PJ, Leung AM (2016) Thyroid dysfunction in children exposed to iodinated contrast media. J Clin Endocrinol Metab 101:2366–2370CrossRefPubMedPubMedCentral
14.
go back to reference Currarino G, Weinberg A, Putnam R (1977) Resorption of contrast material from the bladder during cystourethrography causing an excretory urogram. Radiology 123:149–150CrossRefPubMed Currarino G, Weinberg A, Putnam R (1977) Resorption of contrast material from the bladder during cystourethrography causing an excretory urogram. Radiology 123:149–150CrossRefPubMed
15.
go back to reference Brough R, Jones C (2006) Iatrogenic iodine as a cause of hypothyroidism in infants with end-stage renal failure. Pediatr Nephrol 21:400–402CrossRefPubMed Brough R, Jones C (2006) Iatrogenic iodine as a cause of hypothyroidism in infants with end-stage renal failure. Pediatr Nephrol 21:400–402CrossRefPubMed
Metadata
Title
Iodine excess in children with kidney disease: are we missing hypothyroidism?
Author
Lesley Rees
Publication date
01-07-2019
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 7/2019
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-019-04246-2

Other articles of this Issue 7/2019

Pediatric Nephrology 7/2019 Go to the issue