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Pediatric Nephrology
Published in: Pediatric Nephrology 4/2020

01-04-2020 | Acute Kidney Injury | Educational Review

Malaria and acute kidney injury

Authors: Denver D. Brown, Sonia Solomon, Daniele Lerner, Marcela Del Rio

Published in: Pediatric Nephrology | Issue 4/2020

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Abstract

Malaria is a parasitic infection transmitted by mosquitos, resulting in significant morbidity and mortality. It affects 212 million worldwide, causing death in up to 303,000 children annually. In the USA, up to 1700 people are affected yearly. Although the prevalence in developed countries is less than in developing countries, travelers from low transmission areas, and those from endemic areas who later return, are very susceptible to malaria and its complications. Severe malaria can cause significant multiorgan dysfunction including acute kidney injury (AKI). The pathogenesis is not clearly understood but proposed mechanisms include acute tubular necrosis (ATN) due to impediments in renal microcirculation, infection-triggered proinflammatory reactions within the kidney, and metabolic disturbances. Providers must consider malarial infection in cases of AKI in someone with a travel history, as early recognition and treatment are crucial to improving outcomes. This article will review malaria-induced AKI in order to provide a better understanding of this infection’s effect on the kidneys.
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Metadata
Title
Malaria and acute kidney injury
Authors
Denver D. Brown
Sonia Solomon
Daniele Lerner
Marcela Del Rio
Publication date
01-04-2020
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 4/2020
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-018-4191-0

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