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Pediatric Nephrology
Published in: Pediatric Nephrology 10/2019

01-10-2019 | Review

An update on LDL apheresis for nephrotic syndrome

Authors: Rupesh Raina, Vinod Krishnappa

Published in: Pediatric Nephrology | Issue 10/2019

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Abstract

Low-density lipoprotein (LDL) apheresis has been used increasingly in clinical practice for the treatment of renal diseases with nephrotic syndrome (NS), specifically focal segmental glomerulosclerosis (FSGS). Persistent hyperlipidemia for prolonged periods is nephrotoxic and leads to chronic progressive glomerular and tubulointerstitial injury. Effective management of hyperlipidemia with HMG-CoA reductase inhibitors or LDL apheresis in drug-resistant NS patients may prevent the progression of renal disease and, in some patients, resolution of NS symptoms. Available literature reveals beneficial effects of LDL apheresis for NS refractory to drug therapy. Here we update on the current understanding of lipid nephrotoxicity and application of LDL apheresis to prevent progression of renal diseases.
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Metadata
Title
An update on LDL apheresis for nephrotic syndrome
Authors
Rupesh Raina
Vinod Krishnappa
Publication date
01-10-2019
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 10/2019
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-018-4061-9

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