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Pediatric Nephrology
Published in: Pediatric Nephrology 7/2019

Open Access 01-07-2019 | Review

Mitochondrial mechanisms and therapeutics in ischaemia reperfusion injury

Authors: Jack L. Martin, Anja V. Gruszczyk, Timothy E. Beach, Michael P. Murphy, Kourosh Saeb-Parsy

Published in: Pediatric Nephrology | Issue 7/2019

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Abstract

Acute kidney injury (AKI) remains a major problem in critically unwell children and young adults. Ischaemia reperfusion (IR) injury is a major contributor to the development of AKI in a significant proportion of these cases and mitochondria are increasingly recognised as being central to this process through generation of a burst of reactive oxygen species early in reperfusion. Mitochondria have additionally been shown to have key roles in downstream processes including activation of the immune response, immunomodulation, and apoptosis and necrosis. The recognition of the central role of mitochondria in IR injury and an increased understanding of the pathophysiology that undermines these processes has resulted in identification of novel therapeutic targets and potential biomarkers. This review summarises a variety of therapeutic approaches that are currently under exploration and may have potential in ameliorating AKI in children in the future.
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Metadata
Title
Mitochondrial mechanisms and therapeutics in ischaemia reperfusion injury
Authors
Jack L. Martin
Anja V. Gruszczyk
Timothy E. Beach
Michael P. Murphy
Kourosh Saeb-Parsy
Publication date
01-07-2019
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 7/2019
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-018-3984-5

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