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Pediatric Nephrology
Published in: Pediatric Nephrology 5/2019

01-05-2019 | Educational Review

Uric acid and progression of chronic kidney disease

Author: Donald J. Weaver Jr

Published in: Pediatric Nephrology | Issue 5/2019

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Abstract

The association between serum uric acid levels and human disease has garnered intense interest over the last decade including chronic kidney disease. Animal studies have provided evidence for a potential mechanistic role of uric acid in promoting progression of chronic kidney disease. Epidemiologic studies have also suggested an association between elevated serum uric acid levels and worsening renal function in the general population as well as in patients with chronic kidney disease. However, there is currently insufficient evidence to recommend the use of uric acid-lowering therapy to delay progression of chronic kidney disease in this patient population. Adequately powered, randomized, placebo-controlled trials are required to more precisely evaluate the risk and benefits of uric acid-lowering therapy in pediatric patients.
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Metadata
Title
Uric acid and progression of chronic kidney disease
Author
Donald J. Weaver Jr
Publication date
01-05-2019
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 5/2019
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-018-3979-2

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