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Pediatric Nephrology

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Open Access 01-05-2017 | Original Article

Hypomagnesemia and increased risk of new-onset diabetes mellitus after transplantation in pediatric renal transplant recipients

Authors: Wesley Hayes, Sheila Boyle, Adrian Carroll, Detlef Bockenhauer, Stephen D. Marks

Published in: Pediatric Nephrology | Issue 5/2017

Abstract

Background

New-onset diabetes after transplantation (NODAT) is a significant co-morbidity following kidney transplantation. Lower post-transplant serum magnesium levels have been found to be an independent risk factor for NODAT in adult kidney transplant recipients.

Methods

We undertook a retrospective analysis of risk factors for NODAT in pediatric renal transplant recipients at our institution with the aim of determining if hypomagnesemia confers a significant risk of developing NODAT in this patient population.

Results

A total of 173 children with a median age at transplantation of 7.0 (range 1.3–17.5) years were included. Hypomagnesemia was found to be a significant independent risk factor for NODAT (p = 0.01). High trough tacrolimus levels were also independently associated with NODAT (p < 0.001). There was no significant association between NODAT and body mass index at the time of transplantation, monthly cumulative steroid dose or post-transplant cytomegalovirus viremia (p = 0.9, 0.6 and 0.7, respectively).

Conclusions

This study identifies hypomagnesemia as a significant independent risk factor for the development of NODAT in pediatric renal transplant recipients. Given the clear association between hypomagnesemia and NODAT in both adults and children following renal transplantation, further studies are merited to clarify the etiology of this association and to examine the effect of magnesium supplementation on NODAT.

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Title: Hypomagnesemia and increased risk of new-onset diabetes mellitus after transplantation in pediatric renal transplant recipients
Authors: Wesley Hayes
Sheila Boyle
Adrian Carroll
Detlef Bockenhauer
Stephen D. Marks
Publication date: 01-05-2017
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 5/2017
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-016-3571-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Hypomagnesemia and increased risk of new-onset diabetes mellitus after transplantation in pediatric renal transplant recipients

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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