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Pediatric Nephrology
Published in: Pediatric Nephrology 10/2017

Open Access 01-10-2017 | Clinical Quiz

Diabetes and nephrotic syndrome: Answers

Authors: Rodney D Gilbert, Edward Hind, Bhumita Vadgama

Published in: Pediatric Nephrology | Issue 10/2017

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Excerpt

In principle, when a patient has multiple signs, symptoms or laboratory abnormalities they can be explained in one of four ways:
1)
All the problems may be features of a single disease.
 
2)
Some of the problems may be complications or side effects of treatment given for one or more problems or diseases.
 
3)
One or more problems may be a complication of another condition.
 
4)
The patient may have multiple, unrelated diseases.
 
…
Literature
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Sharma SG, Bomback AS, Radhakrshnan J, Herlitz LC, Stokes MB, Markowitz GS, D’Agati VD (2013) The modern spectrum of renal biopsy findings in patients with diabetes. Clin J Am Soc Nephrol 8:1718–1724CrossRefPubMedPubMedCentral
2.
Lombardo F, Valenzise M, Wasniewska M, Messina MF, Ruggeri C, Arrigo T, De Luca F (2002) Two-year prospective evaluation of the factors affecting honeymoonfrequency and duration in children with insulin dependent diabetes mellitus: the key role of age at diagnosis. Diabetes Nutr Metab 15:246–251PubMed
3.
Yaxley J, Litfin T (2016) Non-steroidal anti-inflammatories and the development of analgesic nephropathy: a systematic review. Renal Fail 5:1–7
4.
van den Ouweland JM, Lemkes HH, Ruitenbeek W, Sandkujl LA, de Vijlder MF, Struyvenberg PA, van de Kamp JJ, Maassen JA (1992) Mutation in mitochondrial tRNA Leu(UUR) gene in a large pedigree with maternally transmitted Type 2 diabetes and deafness. Nat Genet 1:368–371CrossRefPubMed
5.
Murphy R, Turnbull TM, Walker M, Hattersley AT (2008) Clinical features, diagnosis and management of maternally inherited diabetes and deafness (MIDD) associated with the 3243A>G mitochondrial point mutation. Diabetic Med 25:383–399CrossRefPubMed
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Guillausseau PJ, Dubois-Laforge D, Massin P, Laloi-Michelin M, Bellanne-Chantelot C, Gin H, Bellanné-Chantelot C, Gin H, Bertin E, Blickle JF, Bauduceau B, Bouhanick B, Cahen-Varsaux J, Casanova S, Charpentier G, Chedin P, Derrien C, Grimaldi A, Guerci B, Kaloustian E, Lorenzini F, Murat A, Olivier F, Paques M, Paquis-Flucklinger V, Tielmans A, Vincenot M, Vialettes B, Timsit J, GEDIAM, Mitochondrial Diabetes French Study Group (2004) Heterogeneity of diabetes phenotype in patients with 3243-bp mutation of mitochondrial DNA (maternally inherited diabetes and deafness or MIDD). Diabetes Metab 30:181–186CrossRefPubMed
7.
Yamasoba T, Oka T, Tsukuda K, Nakamura M, Kaga K (1996) Auditory findings in patients with maternally inherited diabetes and deafness harboring a point mutation in the mitochondrial transfer RNA Leu(UUR) gene. Laryngoscope 106:49–53CrossRefPubMed
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Massin P, Dubois-Laforgue D, Meas T, Laloi-Michelin M, Gin H, Bauduceau C, Bellanné-Chantelot C, Bertin E, Blickle JF, Bouhanick B, Cahen-Varsaux J, Casanova S, Charpentier G, Chedin P, Dupuy O, Grimaldi A, Guerci B, Kaloustian E, Lecleire-Collet A, Lorenzini F, Murat A, Narbonne H, Olivier F, Paquis-Flucklinger V, Virally M, Vincenot M, Vialettes B, Timsit J, Guillausseau PJ, GEDIAM (Mitochondrial Diabetes French Study Group (2008) Retinal and renal complications in patients with a mutation of mitochondrial DNA at position 3,243 (maternally inherited diabetes and deafness). A case–control study. Diabetologica 51:1664–1670CrossRef
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Jansen JJ, Maassen JA, van der Woude FJ, Lemmink HAJ, van den Ouweland JMW, t Hart LM, Smeets HJM, Bruijn JA, Lemkes HPJ (1997) Mutation in mitochondrial tRNALeu(UUR) gene associated with progressive kidney disease. J Am Soc Nephrol 8:118–1124
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Ohkubo K, Yamano A, Nagashima M, Mori Y, Anzai K, Akehi Y, Nomiyama R, Asano T, Urae A, Ono J (2001) Mitochondrial gene mutations in the tRNA Leu(UUR) region and diabetes: prevalence and clinical phenotypes in Japan. Clin Chem 47:1641–1648PubMed
11.
Koga Y, Akita Y, Takane N, Sato Y, Kato H (2000) Heterogeneous presentation in A3243G mutation in the mitochondrial tRNALeu(UUR) gene. Arch Dis Child 82:407–411CrossRefPubMedPubMedCentral
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Suzuki S, Hinokio Y, Ohtomo M, Hirai M, Hirai A, Chiba M, Kasuga S, Akai H, Toyota T (1998) The effects of coenzyme Q10 treatment on maternally inherited diabetes and deafness, and mitochondrial DNA 3243 (A to G) mutation. Diabetologia 41:584–588CrossRefPubMed
Metadata
Title
Diabetes and nephrotic syndrome: Answers
Authors
Rodney D Gilbert
Edward Hind
Bhumita Vadgama
Publication date
01-10-2017
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 10/2017
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-016-3560-9

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