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Pediatric Nephrology
Published in: Pediatric Nephrology 4/2015

Open Access 01-04-2015 | Educational Review

HLA sensitisation: can it be prevented?

Authors: Lesley Rees, Jon Jin Kim

Published in: Pediatric Nephrology | Issue 4/2015

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Abstract

Human leukocyte antigen (HLA) sensitisation occurs after transfusion of blood products and transplantation. It can also happen spontaneously through cross-sensitisation from infection and pro-inflammatory events. Patients who are highly sensitised face longer waiting times on organ allocation programmes, more graft rejection and therefore more side effects of immunosuppression, and poorer graft outcomes. In this review, we discuss these issues, along with the limitations of modern HLA detection methods, and potential ways of decreasing HLA antibody development. We do not discuss the removal of antibodies after they have developed.
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Metadata
Title
HLA sensitisation: can it be prevented?
Authors
Lesley Rees
Jon Jin Kim
Publication date
01-04-2015
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 4/2015
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-014-2868-6

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