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01-02-2015 | Educational Review

Therapeutic drug monitoring in pediatric renal transplantation

Author: Lutz T. Weber

Published in: Pediatric Nephrology | Issue 2/2015

Abstract

Finding the balance between clinical efficacy and toxicity of immunosuppressive drugs is a challenge in renal transplantation (RTx), but especially in pediatric RTx patients. Due to the expected longer life-span of pediatric transplant patients and the long-term consequences of drug-induced infectious, malignant and cardiovascular adverse effects, protocols which minimize immunosuppressive therapy make conceptual sense. In this context, therapeutic drug monitoring is a tool which provides support for the individualization of therapy. It has, however, limitations, and specific data in the pediatric cohort are comparatively sparse. There is large heterogeneity among the studies conducted to date in terms of methods, follow-up, endpoints, immunosuppressive regimens and patients. In addition, data from adult studies are not readily transferrable to the pediatric situation. This educational review gives a concise overview on aspects of therapeutic drug monitoring in pediatric RTx.

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Title: Therapeutic drug monitoring in pediatric renal transplantation
Author: Lutz T. Weber
Publication date: 01-02-2015
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 2/2015
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-014-2813-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Therapeutic drug monitoring in pediatric renal transplantation

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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