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01-04-2014 | Review

Wt1 in the kidney—a tale in mouse models

Authors: Derya Deniz Ozdemir, Peter Hohenstein

Published in: Pediatric Nephrology | Issue 4/2014

Abstract

The WT1 gene was originally identified through its involvement in the development of Wilms tumours. The gene is characterized by a plethora of different isoforms with, in some cases, clearly different functions in transcriptional control and RNA metabolism. Many different mouse models for Wt1 have already been generated, and these are increasingly providing new information on the molecular roles of Wt1 in normal development and disease. In this review we discuss the different models that have been generated and what they have taught us about the role of Wt1 in the kidney.

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Title: Wt1 in the kidney—a tale in mouse models
Authors: Derya Deniz Ozdemir
Peter Hohenstein
Publication date: 01-04-2014
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 4/2014
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-013-2673-7

At a glance: The STEP trials

Springer Medicine

Wt1 in the kidney—a tale in mouse models

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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