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Pediatric Nephrology
Published in: Pediatric Nephrology 10/2014

01-10-2014 | Clinical Quiz

An infant with recurrent convulsive seizures of 3 weeks’ duration: Answers

Authors: Masaki Shimizu, Yo Niida, Shoichi Koizumi, Akihiro Yachie

Published in: Pediatric Nephrology | Issue 10/2014

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Excerpt

1.
Hypomagnesemia with secondary hypocalcemia
 
2.
Mutations in the TRPM6 gene
 
3.
Early diagnosis and appropriate treatment can lead to good neurological and developmental outcomes. Compliance with long-term treatment with magnesium (Mg) supplements orally is critical to avoid abnormalities in neurological and physical development. Our patient is now 41 years old. He is well, and his neurological developmental and growth, −1.89 standard deviation (SD) for age, have been normal. His bone densitometry readings (1.062 g/cm2; Z score = −0.6) have also been normal. With a therapy consisting of a combination of Mg orally and intermittent Mg sulfate IV, his calcium (Ca), phosphate (P) and alkaline leukocyte phosphatase (ALP) levels remained normal. Serum Mg levels were at the low end of the normal range (1.1–1.3 mEq/L). Over the course of 41 years, he has only complained of mild diarrhea with increased bowel movements.
 
…
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Metadata
Title
An infant with recurrent convulsive seizures of 3 weeks’ duration: Answers
Authors
Masaki Shimizu
Yo Niida
Shoichi Koizumi
Akihiro Yachie
Publication date
01-10-2014
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 10/2014
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-013-2628-z

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