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Pediatric Nephrology

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01-11-2012 | Brief Report

Bartter syndrome and growth hormone deficiency: three cases

Authors: Mithat Buyukcelik, Mehmet Keskin, Beltinge Demircioglu Kilic, Yilmaz Kor, Ayse Balat

Published in: Pediatric Nephrology | Issue 11/2012

Abstract

Background

Bartter syndrome is a rare autosomal recessive disorder characterized by hypokalemia, salt loss, and metabolic alkalosis. Short stature is one of the clinical manifestations in these children. Although polyuria, polydipsia, hypokalemia, and salt loss may be responsible for growth retardation, the exact pathogenesis of short stature in Bartter syndrome is not known.

Case diagnosis and treatment

In this study, we present three children diagnosed as having Bartter syndrome with short stature and growth hormone (GH) deficiency. After recombinant human growth hormone therapy (rhGH), their growth velocities were improved.

Conclusions

These results indicate that GH deficiency may contribute to short stature in children with Bartter syndrome, and rhGH therapy would be an excellent adjunctive treatment for short children with this syndrome whose condition is resistant to conventional therapies in terms of growth.

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Title: Bartter syndrome and growth hormone deficiency: three cases
Authors: Mithat Buyukcelik
Mehmet Keskin
Beltinge Demircioglu Kilic
Yilmaz Kor
Ayse Balat
Publication date: 01-11-2012
Publisher: Springer-Verlag
Published in: Pediatric Nephrology / Issue 11/2012
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-012-2212-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Bartter syndrome and growth hormone deficiency: three cases

Abstract

Background

Case diagnosis and treatment

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case diagnosis and treatment

Conclusions

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